Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential

Nature reviews. Neuroscience, Journal Year: 2018, Volume and Issue: 19(3), P. 138 - 152

Published: Feb. 8, 2018

Language: Английский

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Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain

Neuron, Journal Year: 2018, Volume and Issue: 100(6), P. 1292 - 1311

Published: Dec. 1, 2018

Language: Английский

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Identification of Spinal Circuits Transmitting and Gating Mechanical Pain

Cell, Journal Year: 2014, Volume and Issue: 159(6), P. 1417 - 1432

Published: Nov. 20, 2014

Language: Английский

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Neural circuits for pain: Recent advances and current views

Science, Journal Year: 2016, Volume and Issue: 354(6312), P. 578 - 584

Published: Nov. 3, 2016

The mammalian nervous system encodes many different forms of pain, from those that arise as a result short-term low-grade interactions with noxious thermal, chemical, or mechanical sources to more serious pain induced by trauma and disease. In this Review, we highlight recent advances in our understanding the neural circuits encode these types pain. Promising therapeutic strategies based on are also highlighted.

Language: Английский

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Etiology and Pharmacology of Neuropathic Pain

Pharmacological Reviews, Journal Year: 2018, Volume and Issue: 70(2), P. 315 - 347

Published: March 2, 2018

Injury to or disease of the nervous system can invoke chronic and sometimes intractable neuropathic pain. Many parallel, interdependent, time-dependent processes, including neuroimmune interactions at peripheral, supraspinal, spinal levels, contribute etiology this "disease pain." Recent work emphasizes roles colony-stimulating factor 1, ATP, brain-derived neurotrophic factor. Excitatory processes are enhanced, inhibitory attenuated in dorsal horn throughout somatosensory system. This leads central sensitization aberrant processing such that tactile innocuous thermal information is perceived as pain (allodynia). Processes involved onset differ from those its long-term maintenance. Opioids display limited effectiveness, less than 35% patients derive meaningful benefit other therapeutic approaches. We thus review promising targets have emerged over last 20 years, Na⁺, K⁺, Ca²⁺, hyperpolarization-activated cyclic nucleotide–gated channels, transient receptor potential channel type V1 adenosine A3 receptors. Despite progress, gabapentinoids retain their status first-line treatments, yet mechanism action poorly understood. outline recent progress understanding show how has provided insights into cellular actions pregabalin gabapentin. Interactions with α2δ-1 subunit voltage-gated Ca²⁺ channels produce multiple neuron type-specific cord higher centers. suggest drugs affect rather a single specific target, greatest promise for future development.

Language: Английский

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Virtual Reality as a Distraction Intervention to Relieve Pain and Distress During Medical Procedures

Clinical Journal of Pain, Journal Year: 2018, Volume and Issue: 34(9), P. 858 - 877

Published: Feb. 27, 2018

This review aims to provide a framework for evaluating the utility of virtual reality (VR) as distraction intervention alleviate pain and distress during medical procedures. We first describe theoretical bases underlying VR analgesic anxiolytic effects define main factors contributing its efficacy, which largely emerged from studies on healthy volunteers. Then, we comprehensive overview clinical trials using different procedures, such burn injury treatments, chemotherapy, surgery, dental treatment, other diagnostic therapeutic procedures.A broad literature search was performed terms "virtual reality," "distraction," "pain." No date limit applied all retrieved immersive procedures were selected.VR has proven be effective in reducing procedural pain, almost invariably observed even patients subjected extremely painful with injuries undergoing wound care, physical therapy. Moreover, seemed decrease cancer-related symptoms settings, including chemotherapy. Only mild infrequent side observed.Despite these promising results, future long-term randomized controlled larger sample sizes not only self-report measures but also physiological variables are needed. Further required both establish predictive select who can benefit design hardware/software systems tailored specific needs able greatest at lowest cost.

Language: Английский

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Spinal Cord Stimulation: Clinical Efficacy and Potential Mechanisms

Pain Practice, Journal Year: 2018, Volume and Issue: 18(8), P. 1048 - 1067

Published: March 11, 2018

Spinal cord stimulation (SCS) is a minimally invasive therapy used for the treatment of chronic neuropathic pain. SCS safe and effective alternative to medications such as opioids, multiple randomized controlled studies have demonstrated efficacy difficult-to-treat conditions failed back surgery syndrome. Conventional believed mediate pain relief via activation dorsal column Aβ fibers, resulting in variable effects on sensory thresholds, measurable alterations higher order cortical processing. Although potentiation inhibition, suggested by Wall Melzack's gate control theory, continues be leading explanatory model, other segmental supraspinal mechanisms been described. Novel, non-standard, waveforms high-frequency burst shown some clinically superior conventional SCS, however their action remain determined. Additional are needed, both mechanistic clinical, better understand optimal strategies different conditions, improve patient selection optimize efficacy.

Language: Английский

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Peripheral and Central Mechanisms of Itch

Neuron, Journal Year: 2018, Volume and Issue: 98(3), P. 482 - 494

Published: May 1, 2018

Language: Английский

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Pain regulation by gut microbiota: molecular mechanisms and therapeutic potential

British Journal of Anaesthesia, Journal Year: 2019, Volume and Issue: 123(5), P. 637 - 654

Published: Sept. 21, 2019

The relationship between gut microbiota and neurological diseases, including chronic pain, has received increasing attention. microbiome is a crucial modulator of visceral whereas recent evidence suggests that may also play critical role in many other types inflammatory headache, neuropathic opioid tolerance. We present narrative review the current understanding on pain regulation discuss possibility targeting for management pain. Numerous signalling molecules derived from microbiota, such as by-products metabolites, neurotransmitters, neuromodulators, act their receptors remarkably regulate peripheral central sensitisation, which turn mediate development Gut microbiota-derived mediators serve modulators induction directly or indirectly regulating excitability primary nociceptive neurones. In nervous system, neuroinflammation, involves activation cells blood-brain barrier, microglia, infiltrating immune cells, to modulate maintenance sensitisation. Thus, we propose regulates by diet pharmabiotic intervention represent new therapeutic strategy

Language: Английский

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Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury

Cell Reports, Journal Year: 2015, Volume and Issue: 13(6), P. 1246 - 1257

Published: Nov. 1, 2015

Neuropathic pain is a chronic debilitating disease that results from nerve damage, persists long after the injury has subsided, and characterized by spontaneous mechanical hypersensitivity. Although loss of inhibitory tone in dorsal horn spinal cord major contributor to neuropathic pain, molecular cellular mechanisms underlying this disinhibition are unclear. Here, we combined pharmacogenetic activation selective ablation approaches mice define contribution parvalbumin (PV)-expressing interneurons naive conditions. Ablating PV neurons produce pain-like allodynia via PKCγ excitatory interneurons. Conversely, activating nerve-injured alleviates These findings indicate modality-specific filters gate but not thermal inputs increasing interneuron activity can ameliorate hypersensitivity develops following injury.

Language: Английский

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