STDP-based spiking deep convolutional neural networks for object recognition

Neural Networks, Journal Year: 2017, Volume and Issue: 99, P. 56 - 67

Published: Dec. 23, 2017

Language: Английский

---

Synaptic Plasticity Forms and Functions

Annual Review of Neuroscience, Journal Year: 2020, Volume and Issue: 43(1), P. 95 - 117

Published: Feb. 20, 2020

Synaptic plasticity, the activity-dependent change in neuronal connection strength, has long been considered an important component of learning and memory. Computational engineering work corroborate power through directed adjustment weights. Here we review fundamental elements four broadly categorized forms synaptic plasticity discuss their functional capabilities limitations. Although standard, correlation-based, Hebbian primary focus neuroscientists for decades, it is inherently limited. Three-factor rules supplement with neuromodulation eligibility traces, while true supervised types go even further by adding objectives instructive signals. Finally, a recently discovered hippocampal form combines above elements, leaving behind requirement. We suggest that effort to determine neural basis adaptive behavior could benefit from renewed experimental theoretical investigation more powerful plasticity.

Language: Английский

---

The Neuroscience of Drug Reward and Addiction

Physiological Reviews, Journal Year: 2019, Volume and Issue: 99(4), P. 2115 - 2140

Published: Sept. 11, 2019

Drug consumption is driven by a drug's pharmacological effects, which are experienced as rewarding, and influenced genetic, developmental, psychosocial factors that mediate drug accessibility, norms, social support systems or lack thereof. The reinforcing effects of drugs mostly depend on dopamine signaling in the nucleus accumbens, chronic exposure triggers glutamatergic-mediated neuroadaptations striato-thalamo-cortical (predominantly prefrontal cortical regions including orbitofrontal cortex anterior cingulate cortex) limbic pathways (amygdala hippocampus) that, vulnerable individuals, can result addiction. In parallel, changes extended amygdala negative emotional states perpetuate taking an attempt to temporarily alleviate them. Counterintuitively, addicted person, actual associated with attenuated increase brain reward regions, might contribute drug-taking behavior compensate for difference between magnitude expected triggered conditioning cues experience it. Combined, these enhanced motivation "seek drug" (energized increases cues) impaired top-down self-regulation favors compulsive against backdrop emotionality interoceptive awareness "drug hunger." Treatment interventions intended reverse show promise therapeutic approaches

Language: Английский

---

Synaptic mechanisms underlying persistent cocaine craving

Nature reviews. Neuroscience, Journal Year: 2016, Volume and Issue: 17(6), P. 351 - 365

Published: May 6, 2016

Language: Английский

---

Dopamine Prediction Errors in Reward Learning and Addiction: From Theory to Neural Circuitry

Neuron, Journal Year: 2015, Volume and Issue: 88(2), P. 247 - 263

Published: Oct. 1, 2015

Language: Английский

---

What is resilience: an affiliative neuroscience approach

World Psychiatry, Journal Year: 2020, Volume and Issue: 19(2), P. 132 - 150

Published: May 11, 2020

Resilience - a key topic in clinical science and practice still lacks clear conceptualization that integrates its evolutionary human-specific features, refrains from exclusive focus on fear physiology, incorporates developmental approach, and, most importantly, is not based the negation (i.e., absence of symptoms following trauma). Building initial condition mammals, whose brain matures context mother's body caregiving behavior, we argue systems processes participate tuning to social ecology adapting hardships mark construct resilience. These include oxytocin system, affiliative brain, biobehavioral synchrony, all characterized by great flexibility across phylogenesis ontogenesis. Three core features resilience are outlined: plasticity, sociality meaning. Mechanisms which coordinated action supports diversity, endurance adaptation described animal evolution. Humans' synchrony maternal attuned behavior postpartum adult-adult relationships empathy, perspective-taking intimacy, extends mother-child relationship other bonds throughout life, charting fundamental trajectory development Findings three high-risk cohorts, each tapping distinct disruption maternal-infant bonding (prematurity, depression, early life stress/trauma), followed birth adolescence/young adulthood, demonstrate how components neurobiology affiliation confer uniquely shape brain.

Language: Английский

---

Reward and Aversion

Annual Review of Neuroscience, Journal Year: 2016, Volume and Issue: 39(1), P. 297 - 324

Published: May 5, 2016

To benefit from opportunities and cope with challenges in the environment, animals must adapt their behavior to acquire rewards avoid punishments. Maladaptive changes neuromodulatory systems neural circuits for reward aversion can lead manifestation of several prominent psychiatric disorders including addiction depression. Recent progress is pushing boundaries knowledge on two major fronts research aversion: First, new layers complexity have been reported functions dopamine (DA) serotonin (5-HT) aversion. Second, specific circuit components pathways that encode begun be identified. This review aims outline historic perspectives insights into DA 5-HT coding distinct rewards. It also highlights recent advances studies enabled by technologies, such as cell-type-specific electrophysiology tracing, optogenetics-based behavioral manipulation. may provide guidance developing novel treatment strategies neuropsychiatric diseases related malfunction system.

Language: Английский

---

Distinct Dopamine Receptor Pathways Underlie the Temporal Sensitivity of Associative Learning

Cell, Journal Year: 2019, Volume and Issue: 178(1), P. 60 - 75.e19

Published: June 1, 2019

Language: Английский

---

Rehabilitating the addicted brain with transcranial magnetic stimulation

Nature reviews. Neuroscience, Journal Year: 2017, Volume and Issue: 18(11), P. 685 - 693

Published: Sept. 27, 2017

Language: Английский

---

Aversive Learning and Appetitive Motivation Toggle Feed-Forward Inhibition in the Drosophila Mushroom Body

Neuron, Journal Year: 2016, Volume and Issue: 90(5), P. 1086 - 1099

Published: May 21, 2016

In Drosophila, negatively reinforcing dopaminergic neurons also provide the inhibitory control of satiety over appetitive memory expression. Here we show that aversive learning causes a persistent depression conditioned odor drive to two downstream feed-forward GABAergic interneurons mushroom body, called MVP2, or body output neuron (MBON)-γ1pedc>α/β. However, MVP2 is only essential for expression short-term memory. Stimulating preferentially inhibits odor-evoked activity avoidance-directing MBONs and odor-driven avoidance behavior, whereas their inhibition enhances avoidance. contrast, elevated in hungry flies, required at all times. Moreover, imposing promotes inappropriate food-satiated flies. Aversive motivation therefore toggle alternate modes common pathway promote approach.

Language: Английский

---