Cell Reports,
Journal Year:
2018,
Volume and Issue:
25(1), P. 1 - 9.e5
Published: Oct. 1, 2018
Circadian
clock
dysfunction
is
a
common
symptom
of
aging
and
neurodegenerative
diseases,
though
its
impact
on
brain
health
poorly
understood.
Astrocyte
activation
occurs
in
response
to
diverse
insults
plays
critical
role
disease.
We
report
that
the
core
circadian
protein
BMAL1
regulates
astrogliosis
synergistic
manner
via
cell-autonomous
mechanism
lesser
non-cell-autonomous
signal
from
neurons.
Astrocyte-specific
Bmal1
deletion
induces
astrocyte
inflammatory
gene
expression
vitro
vivo,
mediated
part
by
suppression
glutathione-S-transferase
signaling.
Functionally,
loss
astrocytes
promotes
neuronal
death
vitro.
Our
results
demonstrate
function
elucidating
which
could
influence
many
aspects
neurological
Journal of Biological Rhythms,
Journal Year:
2024,
Volume and Issue:
39(2), P. 135 - 165
Published: Feb. 16, 2024
It
has
been
50
years
since
the
suprachiasmatic
nucleus
(SCN)
was
first
identified
as
central
circadian
clock
and
25
last
overview
of
developments
in
field
published
Journal
Biological
Rhythms.
Here,
we
explore
new
mechanisms
concepts
that
have
emerged
subsequent
years.
Since
1997,
methodological
developments,
such
luminescent
fluorescent
reporter
techniques,
revealed
intricate
relationships
between
cellular
network-level
mechanisms.
In
particular,
specific
neuropeptides
arginine
vasopressin,
vasoactive
intestinal
peptide,
gastrin-releasing
peptide
key
players
synchronization
rhythms
within
SCN.
The
discovery
multiple
oscillators
governing
behavioral
physiological
significantly
advanced
our
understanding
clock.
interaction
neurons
glial
cells
found
to
play
a
crucial
role
regulating
these
Furthermore,
properties
SCN
network
vary
across
ontogenetic
stages.
application
cell
type–specific
genetic
manipulations
components
functional
input-output
system
their
correlation
with
functions.
This
review
concludes
high-risk
effort
identifying
open
questions
challenges
lie
ahead.
Nature Communications,
Journal Year:
2018,
Volume and Issue:
9(1)
Published: March 7, 2018
Abstract
Mammalian
circadian
clocks
have
a
hierarchical
organization,
governed
by
the
suprachiasmatic
nucleus
(SCN)
in
hypothalamus.
The
brain
itself
contains
multiple
loci
that
maintain
autonomous
rhythmicity,
but
contribution
of
non-SCN
to
this
hierarchy
remains
unclear.
We
examine
oscillations
clock
gene
expression
various
and
discovered
mouse,
robust,
higher
amplitude,
relatively
faster
occur
choroid
plexus
(CP)
compared
SCN.
Our
computational
analysis
modeling
show
CP
achieves
these
properties
synchronization
“twist”
oscillators
via
gap-junctional
connections.
Using
an
vitro
tissue
coculture
model
vivo
targeted
deletion
Bmal1
silence
clock,
we
demonstrate
adjusts
SCN
likely
circulation
cerebrospinal
fluid,
thus
finely
tuning
behavioral
rhythms.
Frontiers in Synaptic Neuroscience,
Journal Year:
2018,
Volume and Issue:
10
Published: Nov. 27, 2018
Research
on
glial
cells
over
the
past
30
years
has
confirmed
critical
role
of
astrocytes
in
pathophysiological
brain
states.
However,
most
our
knowledge
about
astrocyte
physiology
and
interactions
between
neurons
is
based
premises
that
constitute
a
homogeneous
cell
type,
without
considering
particular
properties
circuits
or
nuclei
which
are
located.
Therefore,
we
argue
more-sophisticated
experiments
required
to
elucidate
specific
features
different
regions,
even
within
layers
circuit.
Thus,
addition
diverse
mechanisms
used
by
communicate
with
synaptic
partners,
it
necessary
take
into
account
cellular
heterogeneity
likely
contributes
outcomes
astrocyte-neuron
signaling.
In
this
review
article,
briefly
summarize
current
data
regarding
anatomical,
molecular
functional
communication,
as
well
communication.
International Journal of Molecular Sciences,
Journal Year:
2019,
Volume and Issue:
20(2), P. 343 - 343
Published: Jan. 15, 2019
24-h
rhythms
in
physiology
and
behaviour
are
organized
by
a
body-wide
network
of
endogenous
circadian
clocks.
In
mammals,
central
pacemaker
the
hypothalamic
suprachiasmatic
nucleus
(SCN)
integrates
external
light
information
to
adapt
cellular
clocks
all
tissues
organs
light-dark
cycle.
Together,
peripheral
co-regulate
physiological
functions.
this
review,
we
outline
current
knowledge
about
routes
communication
between
environment,
main
pacemakers
downstream
body,
focusing
on
what
currently
know
still
need
understand
mechanisms
which
centrally
peripherally
controlled
timing
signals
coordinate
functions
behaviour.
We
highlight
recent
findings
that
shed
new
internal
organization
function
SCN
neuroendocrine
mediating
clock-to-clock
coupling.
These
have
implications
for
our
understanding
entrainment
potential
manipulations
clock
system
therapeutic
settings.
Cell Reports,
Journal Year:
2018,
Volume and Issue:
25(1), P. 1 - 9.e5
Published: Oct. 1, 2018
Circadian
clock
dysfunction
is
a
common
symptom
of
aging
and
neurodegenerative
diseases,
though
its
impact
on
brain
health
poorly
understood.
Astrocyte
activation
occurs
in
response
to
diverse
insults
plays
critical
role
disease.
We
report
that
the
core
circadian
protein
BMAL1
regulates
astrogliosis
synergistic
manner
via
cell-autonomous
mechanism
lesser
non-cell-autonomous
signal
from
neurons.
Astrocyte-specific
Bmal1
deletion
induces
astrocyte
inflammatory
gene
expression
vitro
vivo,
mediated
part
by
suppression
glutathione-S-transferase
signaling.
Functionally,
loss
astrocytes
promotes
neuronal
death
vitro.
Our
results
demonstrate
function
elucidating
which
could
influence
many
aspects
neurological
