Co-coding of head and whisker movements by both VPM and POm thalamic neurons

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 13, 2024

Abstract Rodents continuously move their heads and whiskers in a coordinated manner while perceiving objects through whisker-touch. Studies head-fixed rodents showed that the ventroposterior medial (VPM) posterior (POm) thalamic nuclei code for whisker kinematics, with POm involvement reduced awake animals. To examine VPM coding head kinematics awake, head-free conditions, we recorded neuronal activity tracked movements male mice exploring an open arena. Using optogenetic tagging, found freely moving mice, both equally coded robustly kinematics. The fraction of neurons increased after trimming, ruling out whisker-mediated coding. Optogenetic activation evoked overt kinematic changes leading Our data suggest integrate information can influence during tactile perception.

Language: Английский

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Three-dimensional architecture and linearized mapping of vibrissa follicle afferents

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 8, 2025

Language: Английский

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Synaptic motility and functional stability in the whisker cortex

Physical Review Research, Journal Year: 2025, Volume and Issue: 7(1)

Published: Jan. 29, 2025

The high motility of synaptic weights raises the question how brain can retain its functionality in face constant remodeling. Here we used whisker system rats and mice to study interplay between plasticity (motility) transmission sensory signals downstream. Rats probe their surroundings by rhythmically moving whiskers back forth. azimuthal position a be estimated from activity whisking neurons that respond selectively preferred phase along cycle. These phases are widely distributed on ring. However, simple models for signal downstream predict distribution is an order magnitude narrower than empirically observed. Here, suggest form spike-timing-dependent (STDP) may provide solution this conundrum. This hypothesis addressed framework modeling investigated STDP dynamics population synapses propagates findings showed that, wide range parameters, do not relax fixed point. As result, drift time at nonuniform velocity, which turn induces population. demonstrates functionality, terms phases, retained simply despite, but because motility. Our analysis leads several key empirical predictions test hypothesis. Published American Physical Society 2025

Language: Английский

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Neuromorphic Hardware for Artificial Sensory Systems: A Review

Journal of Electronic Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Abstract Senses are crucial for an organism’s survival, and there have been numerous efforts to artificially replicate sensory perception elicit desired responses specific stimuli. Recent research is increasingly focused on developing artificial nervous systems based the unsupervised learning capabilities of neural networks (ANNs) using unstructured data. However, future ANNs, which require precise sensing in complex environments, must be capable processing a large number signals real time, ideally from continuous domains. This need massive data driving evolution hardware systems, leading development devices specifically designed (ASSs) at level. To address this challenge, sensor not only detect target substances but also enable computational functions by utilizing their inherent material properties. Research neuromorphic sensors advancing towards integration with next-generation effectively addressing scenarios we aim identify. review offers perspectives human-like computing these challenges. It examines progress implementing five representative senses device level, explores methods integrating them into ASS, provides comprehensive overview potential applications. In particular, emphasize approaches cognitively utilize discussed as neurons synapses, enabling inputs. We offer nerve future.

Language: Английский

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Coding of whisker motion across the mouse face

eLife, Journal Year: 2019, Volume and Issue: 8

Published: Feb. 28, 2019

Haptic perception synthesizes touch with proprioception, the sense of body position. Humans and mice alike experience rich active face. Because most facial muscles lack proprioceptor endings, sensory basis proprioception remains unsolved. Facial may instead rely on mechanoreceptors that encode both self-motion. In rodents, whisker provide a signal informs brain about Whisking involves coordinated orofacial movements, so innervating regions other than whiskers could also information whisking. To define all sources whisking available to brain, we recorded spikes from diverse parts Whisker motion was encoded best by mechanoreceptors, but those pad hairy skin supraorbital vibrissae. Redundant self-motion responses stable proprioceptive despite mechanical perturbations during touch.

Language: Английский

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