Shaping Neuronal Fate: Functional Heterogeneity of Direct Microglia-Neuron Interactions

Neuron, Journal Year: 2020, Volume and Issue: 109(2), P. 222 - 240

Published: Dec. 2, 2020

Language: Английский

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Sepsis-Associated Encephalopathy: From Delirium to Dementia?

Journal of Clinical Medicine, Journal Year: 2020, Volume and Issue: 9(3), P. 703 - 703

Published: March 5, 2020

Sepsis is a major cause of death in intensive care units worldwide. The acute phase sepsis often accompanied by sepsis-associated encephalopathy, which highly associated with increased mortality. Moreover, the chronic phase, more than 50% surviving patients suffer from severe and long-term cognitive deficits compromising their daily quality life placing an immense burden on primary caregivers. Due to growing number survivors, these long-lasting are increasingly relevant. Despite high incidence clinical relevance, pathomechanisms stages encephalopathy only incompletely understood, no specific therapeutic options yet available. Here, we review emergence initial presentation impairment survivors summarize potentially contributing development encephalopathy.

Language: Английский

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Astrocyte-immune cell interactions in physiology and pathology

Immunity, Journal Year: 2021, Volume and Issue: 54(2), P. 211 - 224

Published: Feb. 1, 2021

Language: Английский

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Gene therapy for neurodegenerative disorders: advances, insights and prospects

Acta Pharmaceutica Sinica B, Journal Year: 2020, Volume and Issue: 10(8), P. 1347 - 1359

Published: Jan. 31, 2020

Gene therapy is rapidly emerging as a powerful therapeutic strategy for wide range of neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's (PD) and Huntington's (HD). Some early clinical trials have failed to achieve satisfactory effects. Efforts enhance effectiveness are now concentrating on three major fields: identification new vectors, novel targets, reliable delivery routes transgenes. These approaches being assessed closely in preclinical trials, which may ultimately provide treatments patients. Here, we discuss advances challenges gene highlighting promising technologies, future prospects.

Language: Английский

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Astrocyte energy and neurotransmitter metabolism in Alzheimer’s disease: Integration of the glutamate/GABA-glutamine cycle

Progress in Neurobiology, Journal Year: 2022, Volume and Issue: 217, P. 102331 - 102331

Published: July 21, 2022

Language: Английский

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