Proceedings of the National Academy of Sciences,
Journal Year:
2022,
Volume and Issue:
119(18)
Published: April 29, 2022
Significance
Brainstem
locus
coeruleus
(LC)
noradrenergic
neurons
produce
an
arousal-related
state
characterized
by
a
broadband
increase
in
high-frequency
oscillations.
This
perspective
was
built
upon
electrical
or
optogenetic
stimulation
that
artificially
activates
LC
synchronously.
has
led
to
the
conceptual
model
activation
is
associated
with
single
cortical
state.
Here,
we
show
natural,
spontaneously
occurring
single-unit
activity
consists
of
ensembles
largely
nonoverlapping
dynamics.
Spontaneous
activations
different
are
states.
Our
results
suggest
role
controlling
type
arousal
oversimplification.
Instead,
may
control
diverse
multitude
Annual Review of Neuroscience,
Journal Year:
2020,
Volume and Issue:
43(1), P. 249 - 275
Published: July 8, 2020
Significant
experimental,
computational,
and
theoretical
work
has
identified
rich
structure
within
the
coordinated
activity
of
interconnected
neural
populations.
An
emerging
challenge
now
is
to
uncover
nature
associated
computations,
how
they
are
implemented,
what
role
play
in
driving
behavior.
We
term
this
computation
through
population
dynamics.
If
successful,
framework
will
reveal
general
motifs
quantitatively
describe
dynamics
implement
computations
necessary
for
goal-directed
Here,
we
start
with
a
mathematical
primer
on
dynamical
systems
theory
analytical
tools
apply
perspective
experimental
data.
Next,
highlight
some
recent
discoveries
resulting
from
successful
application
systems.
focus
studies
spanning
motor
control,
timing,
decision-making,
working
memory.
Finally,
briefly
discuss
promising
lines
investigation
future
directions
framework.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: June 27, 2022
Abstract
Cell
interactions
determine
phenotypes,
and
intercellular
communication
is
shaped
by
cellular
contexts
such
as
disease
state,
organismal
life
stage,
tissue
microenvironment.
Single-cell
technologies
measure
the
molecules
mediating
cell–cell
communication,
emerging
computational
tools
can
exploit
these
data
to
decipher
communication.
However,
current
methods
either
disregard
context
or
rely
on
simple
pairwise
comparisons
between
samples,
thus
limiting
ability
complex
across
multiple
time
points,
levels
of
severity,
spatial
contexts.
Here
we
present
Tensor-cell2cell,
an
unsupervised
method
using
tensor
decomposition,
which
deciphers
context-driven
simultaneously
accounting
for
stages,
states,
locations
cells.
To
do
so,
Tensor-cell2cell
uncovers
patterns
associated
with
different
phenotypic
states
determined
unique
combinations
cell
types
ligand-receptor
pairs.
As
such,
robustly
improves
upon
extends
analytical
capabilities
existing
tools.
We
show
identify
modules
distinct
processes
(e.g.,
participating
pairs)
linked
severities
Coronavirus
Disease
2019
Autism
Spectrum
Disorder.
Thus,
introduce
effective
easy-to-use
strategy
understanding
diverse
conditions.
Science,
Journal Year:
2024,
Volume and Issue:
384(6693)
Published: April 18, 2024
Drugs
of
abuse
are
thought
to
promote
addiction
in
part
by
“hijacking”
brain
reward
systems,
but
the
underlying
mechanisms
remain
undefined.
Using
whole-brain
FOS
mapping
and
vivo
single-neuron
calcium
imaging,
we
found
that
drugs
augment
dopaminoceptive
ensemble
activity
nucleus
accumbens
(NAc)
disorganize
overlapping
responses
natural
rewards
a
cell
type–specific
manner.
Combining
FOS-Seq,
CRISPR-perturbation,
single-nucleus
RNA
sequencing,
identified
Rheb
as
molecular
substrate
regulates
signal
transduction
NAc
while
enabling
suppress
consumption.
Mapping
NAc-projecting
regions
activated
revealed
input-specific
effects
on
These
findings
characterize
dynamic,
circuit
basis
common
pathway,
wherein
interfere
with
fulfillment
innate
needs.
