Shaping Neuronal Fate: Functional Heterogeneity of Direct Microglia-Neuron Interactions

Neuron, Journal Year: 2020, Volume and Issue: 109(2), P. 222 - 240

Published: Dec. 2, 2020

Language: Английский

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Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer’s Disease

Neuron, Journal Year: 2020, Volume and Issue: 108(5), P. 801 - 821

Published: Oct. 23, 2020

Language: Английский

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Immune checkpoint modulators in cancer immunotherapy: recent advances and emerging concepts

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: Aug. 17, 2022

Abstract The discovery of immune checkpoint inhibitors (ICIs) has now been universally acknowledged as a significant breakthrough in tumor therapy after the targeted treatment molecules: anti-programmed cell death protein 1/programmed ligand 1 (PD-1/PD-L1) and anti-cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) on several cancer types achieved satisfying results. However, there are still quite lot patients suffering from severe side effects ineffective outcomes. Although current ICI is far satisfying, series novel molecules with remarkable preclinical clinical benefits being widely investigated, like V-domain Ig suppressor activation (VISTA), which can also be called PD-1 homolog (PD-1H), ectonucleotidases: CD39, CD73, CD38, belong to ribosyl cyclase family, etc. In this review, we systematically summarized discussed these molecules' biological structures, molecular features, corresponding drugs, aiming help in-depth understanding promote practice therapy.

Language: Английский

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The Inflamed Brain in Schizophrenia: The Convergence of Genetic and Environmental Risk Factors That Lead to Uncontrolled Neuroinflammation

Frontiers in Cellular Neuroscience, Journal Year: 2020, Volume and Issue: 14

Published: Aug. 27, 2020

Schizophrenia is a disorder with heterogeneous etiology involving complex interplay between genetic and environmental risk factors. The immune system now known to play vital roles in nervous function pathology through regulating neuronal glial development, synaptic plasticity, behavior. In this regard, the positioned as common link seemingly diverse factors for schizophrenia. Synthesizing information about how immune-brain axis affected by multiple these might interact schizophrenia necessary better understand pathogenesis of disease. Such knowledge will aid development more translatable animal models that may lead effective therapeutic interventions. Here, we provide an overview modulate function. We also explore including exposure pollution, gut dysbiosis, maternal activation early-life stress, consequences are linked microglial dysfunction. propose morphological signaling deficits blood-brain barrier, observed some individuals schizophrenia, can act gateway peripheral central inflammation, thus affecting microglia their essential functions. Finally, describe response neuroinflammation impact on brain homeostasis, well pathophysiology.

Language: Английский

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Microglia-neuron crosstalk: Signaling mechanism and control of synaptic transmission

Seminars in Cell and Developmental Biology, Journal Year: 2019, Volume and Issue: 94, P. 138 - 151

Published: May 30, 2019

Language: Английский

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