Peripheral and central immune system crosstalk in Alzheimer disease — a research prospectus

Nature Reviews Neurology, Journal Year: 2021, Volume and Issue: 17(11), P. 689 - 701

Published: Sept. 14, 2021

Language: Английский

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Neuromodulation by the immune system: a focus on cytokines

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 21(8), P. 526 - 541

Published: March 1, 2021

Language: Английский

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Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein

Translational Neurodegeneration, Journal Year: 2019, Volume and Issue: 8(1)

Published: March 1, 2019

Abnormal aggregation of brain α-synuclein is a central step in the pathogenesis Parkinson's disease (PD), thus, it reliable to promote clearance prevent and treat PD. Recent studies have revealed an essential role glymphatic system meningeal lymphatic vessels macromolecules, however, their pathophysiological aspects remain elusive.Meningeal drainage 18-week-old A53T mice was blocked via ligating deep cervical lymph nodes. Six weeks later, functions PD-like phenotypes were systemically analyzed.Glymphatic influx cerebrospinal fluid tracer reduced mice, accompanied with perivascular impaired polarization aquaporin 4 expression substantia nigra. Cervical ligation aggravated dysfunction causing more severe accumulation α-synuclein, glial activation, inflammation, dopaminergic neuronal loss motor deficits.The results suggest that may be aggravating factor PD pathology.

Language: Английский

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Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy

Nature, Journal Year: 2021, Volume and Issue: 593(7858), P. 255 - 260

Published: April 28, 2021

Language: Английский

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Meningeal Immunity and Its Function in Maintenance of the Central Nervous System in Health and Disease

Annual Review of Immunology, Journal Year: 2020, Volume and Issue: 38(1), P. 597 - 620

Published: April 26, 2020

Neuroimmunology, albeit a relatively established discipline, has recently sparked numerous exciting findings on microglia, the resident macrophages of central nervous system (CNS). This review addresses meningeal immunity, less-studied aspect neuroimmune interactions. The meninges, triple layer membranes—the pia mater, arachnoid and dura mater—surround CNS, encompassing cerebrospinal fluid produced by choroid plexus epithelium. Unlike adjacent brain parenchyma, meninges contain wide repertoire immune cells. These constitute which is primarily concerned with surveillance and—according to recent evidence—also participates in postinjury CNS recovery, chronic neurodegenerative conditions, even higher function. Meningeal immunity come under spotlight owing characterization lymphatic vessels draining CNS. Here, we current state our understanding its effects healthy diseased brains.

Language: Английский

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Impaired meningeal lymphatic drainage in patients with idiopathic Parkinson’s disease

Nature Medicine, Journal Year: 2021, Volume and Issue: 27(3), P. 411 - 418

Published: Jan. 18, 2021

Language: Английский

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The Glymphatic System: A Novel Component of Fundamental Neurobiology

Journal of Neuroscience, Journal Year: 2021, Volume and Issue: 41(37), P. 7698 - 7711

Published: Sept. 15, 2021

Throughout the body, lymphatic fluid movement supports critical functions including clearance of excess and metabolic waste. The glymphatic system is analog in CNS. As such, plays a key role regulating directional interstitial movement, waste clearance, and, potentially, brain immunity. enables bulk CSF from subarachnoid space along periarterial spaces, where it mixes with within parenchyma before ultimately exiting via perivenous spaces. This review focuses on important questions about structure this system, why needs transport unexplored aspects transport. We provide evidence that astrocytes blood vessels determine shape perivascular space, controlling fluid. Glymphatic has potential to alter local as well global signaling molecules metabolites. also highlight for cross talk among cardiovascular gastrointestinal tract, system. Much remains be studied, but we propose glymphatic/lymphatic acts cornerstone between body.

Language: Английский

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Cerebrospinal fluid tracer efflux to parasagittal dura in humans

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: Jan. 17, 2020

Abstract The mechanisms behind molecular transport from cerebrospinal fluid to dural lymphatic vessels remain unknown. This study utilized magnetic resonance imaging along with tracer visualize clearance pathways human lymphatics in vivo. In 18 subjects suspicion of various types disorders, 3D T2-Fluid Attenuated Inversion Recovery, T1-black-blood, and T1 gradient echo acquisitions were obtained prior intrathecal administration the contrast agent gadobutrol (0.5 ml, 1 mmol/ml), serving as a tracer. Propagation was followed sequences at 3, 6, 24 48 h after injection. escaped into parasagittal dura superior sagittal sinus areas nearby entry cortical cerebral veins. findings demonstrate that trans-arachnoid passage does occur suggest may serve bridging link between brain vessels.

Language: Английский

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Microbiota-derived metabolites as drivers of gut–brain communication

Gut Microbes, Journal Year: 2022, Volume and Issue: 14(1)

Published: July 28, 2022

Alterations in the gut microbiota composition have been associated with a range of neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. The microbes transform metabolize dietary- host-derived molecules generating diverse group metabolites local systemic effects. bi-directional communication between brain residing gut, so-called gut–brain axis, consists network immunological, neuronal, endocrine signaling pathways. Although full variety mechanisms crosstalk is yet to be established, existing data demonstrates that single metabolite or its derivatives are likely among key inductors within axis communication. However, more research needed understand molecular underlying how alter functions, examine if different interventional approaches targeting could used prevention treatment neurological disorders, as reviewed herein.Abbreviations:4-EPS 4-ethylphenylsulfate; 5-AVA(B) 5-aminovaleric acid (betaine); Aβ Amyloid beta protein; AhR Aryl hydrocarbon receptor; ASD Autism spectrum disorder; BBB Blood–brain barrier; BDNF Brain-derived neurotrophic factor; CNS Central nervous system; GABA ɣ-aminobutyric acid; GF Germ-free; MIA Maternal immune activation; SCFA Short-chain fatty 3M-4-TMAB 3-methyl-4-(trimethylammonio)butanoate; 4-TMAP 4-(trimethylammonio)pentanoate; TMA(O) Trimethylamine(-N-oxide); TUDCA Tauroursodeoxycholic ZO Zonula occludens proteins

Language: Английский

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Emerging roles of innate and adaptive immunity in Alzheimer’s disease

Immunity, Journal Year: 2022, Volume and Issue: 55(12), P. 2236 - 2254

Published: Nov. 8, 2022

Language: Английский

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