Explicit Control of Step Timing During Split-Belt Walking Reveals Interdependent Recalibration of Movements in Space and Time DOI Creative Commons
Marcela Gonzalez-Rubio,

Nicolas F Velasquez,

Gelsy Torres‐Oviedo

et al.

Frontiers in Human Neuroscience, Journal Year: 2019, Volume and Issue: 13

Published: July 3, 2019

Split-belt treadmills that move the legs at different speeds are thought to update internal representations of environment, such this novel condition generates a new locomotor pattern with distinct spatio-temporal features compared those regular walking. It is unclear degree which recalibration movements in spatial and temporal domains interdependent. In study, we explicitly altered subjects' limb motion either space or time during split-belt walking determine its impact on adaptation other domain. Interestingly, observed motor domain was susceptible altering domain, whereas resilient modifying This non-reciprocal relation suggests hierarchical organization control timing locomotion has an effect position. translational interest because clinical populations often have greater deficit one other. Our results suggest explicit changes deficits cannot occur without limb.

Language: Английский

Cortico-basal ganglia plasticity in motor learning DOI Creative Commons
Richard H. Roth, Jun Ding

Neuron, Journal Year: 2024, Volume and Issue: 112(15), P. 2486 - 2502

Published: July 12, 2024

Language: Английский

Citations

9
Fundamental processes in sensorimotor learning: Reasoning, refinement, and retrieval DOI Creative Commons
Jonathan S. Tsay, Hyosub E. Kim, Samuel D. McDougle

et al.

eLife, Journal Year: 2024, Volume and Issue: 13

Published: Aug. 1, 2024

Motor learning is often viewed as a unitary process that operates outside of conscious awareness. This perspective has led to the development sophisticated models designed elucidate mechanisms implicit sensorimotor learning. In this review, we argue for broader perspective, emphasizing contribution explicit strategies tasks. Furthermore, propose theoretical framework motor consists three fundamental processes: reasoning, understanding action–outcome relationships; refinement, optimizing and cognitive parameters achieve goals; retrieval, inferring context recalling control policy. We anticipate ‘3R’ how complex movements are learned will open exciting avenues future research at intersection between cognition action.

Language: Английский

Citations

9
Miniature linear and split-belt treadmills reveal mechanisms of adaptive motor control in walking Drosophila DOI
Brandon Pratt, Su-Yee J. Lee, Grant M Chou

et al.

Current Biology, Journal Year: 2024, Volume and Issue: 34(19), P. 4368 - 4381.e5

Published: Aug. 30, 2024

Language: Английский

Citations

9
Cerebellar control of targeted tongue movements DOI Creative Commons
Lorenzo Bina,

Camilla Ciapponi,

Si‐yang Yu

et al.

The Journal of Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

Abstract The cerebellum is critical for coordinating movements related to eating, drinking and swallowing, all of which require proper control the tongue. Cerebellar Purkinje cells can encode tongue movements, but it unclear how their simple spikes complex induce changes in shape that contribute goal‐directed movements. To study these relations, we recorded stimulated vermis hemispheres mice during spontaneous licking from a stationary or moving water spout. We found rhythmic with both spikes. Increased spike firing protrusion induces ipsiversive bending Unexpected target location trigger alter subsequent licks, adjusting trajectory. Furthermore, observed increased behavioural state at start end bouts. Using machine learning, confirmed alterations cell activity accompany licking, different often exerting heterogeneous encoding schemes. Our data highlight directional movement paramount cerebellar function modulation are complementary acquisition execution sensorimotor coordination. These results bring us closer understanding clinical implications disorders swallowing. image Key points When drinking, make directed towards source. fire rhythmically tune position source affects direction report also adjust right direction.

Language: Английский

Citations

1
Cerebellar output neurons can impair non-motor behaviors by altering development of extracerebellar connectivity DOI Creative Commons
Andrew S. Lee, Tanzil Mahmud Arefin,

Alina Gubanova

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 21, 2025

Language: Английский

Citations

1
Cerebellospinal Neurons Regulate Motor Performance and Motor Learning DOI Creative Commons
Anupama Sathyamurthy, Arnab Barik, Courtney I. Dobrott

et al.

Cell Reports, Journal Year: 2020, Volume and Issue: 31(6), P. 107595 - 107595

Published: May 1, 2020

To understand the neural basis of behavior, it is important to reveal how movements are planned, executed, and refined by networks neurons distributed throughout nervous system. Here, we report neuroanatomical organization behavioral roles cerebellospinal (CeS) neurons. Using intersectional genetic techniques, find that CeS constitute a small minority excitatory in fastigial interpositus deep cerebellar nuclei, target pre-motor circuits ventral spinal cord brain, control distinct aspects movement. project ipsilateral cervical required for skilled forelimb performance, while contralateral involved locomotor learning. Together, this work establishes as critical component circuitry provides insights into organizational logic motor networks.

Language: Английский

Citations

66
Using asymmetry to your advantage: learning to acquire and accept external assistance during prolonged split-belt walking DOI
Natalia Sánchez, Surabhi N. Simha, J. Maxwell Donelan

et al.

Journal of Neurophysiology, Journal Year: 2020, Volume and Issue: 125(2), P. 344 - 357

Published: Dec. 9, 2020

Split-belt treadmill adaptation can be seen as a process where people learn to acquire positive work from the reduce energetic cost. Though we know what should do cost, this strategy is not observed during studies. We extended duration of and show that continuously adapt their gait This requires longer exposure than traditionally allotted.

Language: Английский

Citations

58
A rapid whisker-based decision underlying skilled locomotion in mice DOI Creative Commons
Richard Warren, Qianyun Zhang, Judah R. Hoffman

et al.

eLife, Journal Year: 2021, Volume and Issue: 10

Published: Jan. 11, 2021

Skilled motor behavior requires rapidly integrating external sensory input with information about internal state to decide which movements make next. Using machine learning approaches for high-resolution kinematic analysis, we uncover the logic of a rapid decision underlying sensory-guided locomotion in mice. After detecting obstacles their whiskers mice select distinct strategies depending on whisker-derived estimate obstacle location together position and velocity body. Although rely avoidance, lesions primary whisker cortex had minimal impact. While manipulations affected execution chosen strategy, decision-making process remained largely intact. These results highlight potential reductionist analysis naturalistic behaviors provide case subcortical brain structures appear sufficient mediating relatively sophisticated sensorimotor decision.

Language: Английский

Citations

47
A Synthesis of the Many Errors and Learning Processes of Visuomotor Adaptation DOI Creative Commons
J. Ryan Morehead, Jean‐Jacques Orban de Xivry

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2021, Volume and Issue: unknown

Published: March 15, 2021

Abstract Visuomotor adaptation has one of the oldest experimental histories in psychology and neuroscience, yet its precise nature always been a topic debate. Here we offer survey synthesis recent work on visuomotor that hope will prove illuminating for this ongoing dialogue. We discuss three types error signals drive learning tasks: task performance error, sensory prediction-error, binary target hitting error. Each these errors shown to distinct processes. Namely, both putative prediction-errors an implicit change maps, while drives explicit strategy use non-motor decision-making. processes contributes overall takes place tasks, although are independent, they interact complex manner. outline many contexts where operation is counter-intuitive general guidelines their control, measurement interpretation. believe new framework unifies several disparate threads research sensorimotor often seem conflict. conclude by explaining how more nuanced understanding could lend itself analysis other adaptation, motor skill learning, neural processing underlying humans, animal models brain computer interfaces.

Language: Английский

Citations

47
Consensus Paper: Ataxic Gait DOI
Pierre Cabaraux, Sunil K. Agrawal, Huaying Cai

et al.

The Cerebellum, Journal Year: 2022, Volume and Issue: 22(3), P. 394 - 430

Published: April 12, 2022

Language: Английский

Citations

29