Journal of Inflammation Research,
Journal Year:
2022,
Volume and Issue:
Volume 15, P. 6213 - 6230
Published: Nov. 1, 2022
Abstract:
The
gut
microbiota
is
the
most
abundant
and
diverse
in
human
body
vagus
nerve
widely
distributed
complex
body,
both
of
them
are
essential
maintaining
homeostasis.
important
phenomenon
how
they
coordinate
to
regulate
functions,
which
has
attracted
great
attention
scientists.
academic
literature
on
correlation
with
a
host
intestinal
diseases
even
systemic
revealed
bidirectional
communication
between
brain,
can
be
carried
out
via
multiple
patterns.
In
review,
firstly,
we
have
general
overview
microbiota-brain
axis.
Secondly,
according
distribution
characteristics
nerve,
analyzed
summarized
its
function
tract.
At
same
time,
underlying
mechanism
some
behavior
changes
such
as
depressive
anxiety-like
behaviors
related
neurodegenerative
caused
by
microecological
environment
disorders,
then
also
inconsistency
experimental
evidence
order
propose
novel
strategies
for
clinical
practice.
Keywords:
axis,
microbiota,
behavior,
Frontiers in Endocrinology,
Journal Year:
2023,
Volume and Issue:
14
Published: June 19, 2023
Cognitive
function
in
humans
depends
on
the
complex
and
interplay
between
multiple
body
systems,
including
hypothalamic-pituitary-adrenal
(HPA)
axis.
The
gut
microbiota,
which
vastly
outnumbers
human
cells
has
a
genetic
potential
that
exceeds
of
genome,
plays
crucial
role
this
interplay.
microbiota-gut-brain
(MGB)
axis
is
bidirectional
signalling
pathway
operates
through
neural,
endocrine,
immune,
metabolic
pathways.
One
major
neuroendocrine
systems
responding
to
stress
HPA
produces
glucocorticoids
such
as
cortisol
corticosterone
rodents.
Appropriate
concentrations
are
essential
for
normal
neurodevelopment
function,
well
cognitive
processes
learning
memory,
studies
have
shown
microbes
modulate
throughout
life.
Stress
can
significantly
impact
MGB
via
other
Animal
research
advanced
our
understanding
these
mechanisms
pathways,
leading
paradigm
shift
conceptual
thinking
about
influence
microbiota
health
disease.
Preclinical
trials
currently
underway
determine
how
animal
models
translate
humans.
In
review
article,
we
summarize
current
knowledge
relationship
axis,
cognition,
provide
an
overview
main
findings
conclusions
broad
field.
Neuroscience & Biobehavioral Reviews,
Journal Year:
2021,
Volume and Issue:
125, P. 698 - 761
Published: March 5, 2021
There
is
increasing
knowledge
regarding
the
role
of
microbiome
in
modulating
brain
and
behaviour.
Indeed,
actions
microbial
metabolites
are
key
for
appropriate
gut-brain
communication
humans.
Among
these
metabolites,
short-chain
fatty
acids,
tryptophan,
bile
acid
metabolites/pathways
show
strong
preclinical
evidence
involvement
various
aspects
function
With
identification
neuroactive
modules,
new
predictive
tools
can
be
applied
to
existing
datasets.
We
identified
278
studies
relating
human
microbiota-gut-brain
axis
which
included
sequencing
data.
This
spanned
across
psychiatric
neurological
disorders
with
a
small
number
also
focused
on
normal
behavioural
development.
consistent
bioinformatics
pipeline,
thirty-five
datasets
were
reanalysed
from
publicly
available
raw
files
remainder
summarised
collated.
studies,
we
uncovered
disease-related
alterations
metabolic
pathways
Alzheimer's
Disease,
schizophrenia,
anxiety
depression.
Amongst
that
could
not
reanalysed,
many
technical
limitations
hindered
discovery
specific
biomarkers
microbes
or
conserved
studies.
Future
warranted
confirm
our
findings.
propose
guidelines
future
analysis
increase
reproducibility
consistency
within
field.
Frontiers in Aging Neuroscience,
Journal Year:
2021,
Volume and Issue:
13
Published: May 28, 2021
Alzheimer's
disease
(AD)
is
the
most
common
age-related
progressive
neurodegenerative
disease,
characterized
by
a
decline
in
cognitive
function
and
neuronal
loss,
caused
several
factors.
Numerous
clinical
experimental
studies
have
suggested
involvement
of
gut
microbiota
dysbiosis
patients
with
AD.
The
altered
can
influence
brain
behavior
through
microbiota-gut-brain
axis
via
various
pathways
such
as
increased
amyloid-β
deposits
tau
phosphorylation,
neuroinflammation,
metabolic
dysfunctions,
chronic
oxidative
stress.
With
no
current
effective
therapy
to
cure
AD,
modulation
may
be
promising
therapeutic
option
prevent
or
delay
onset
AD
counteract
its
progression.
Our
present
review
summarizes
alterations
pathogenetic
roles
mechanisms
microbiota-targeted
therapies
for
Understanding
between
will
help
decipher
pathogenesis
from
novel
perspectives
shed
light
on
strategies
Frontiers in Neuroscience,
Journal Year:
2023,
Volume and Issue:
17
Published: Aug. 4, 2023
The
gut
microbiota
(GM)
plays
an
important
role
in
the
physiology
and
pathology
of
host.
Microbiota
communicate
with
different
organs
organism
by
synthesizing
hormones
regulating
body
activity.
interaction
central
nervous
system
(CNS)
signaling
pathways
includes
chemical,
neural
immune
endocrine
routes.
Alteration
or
dysbiosis
leads
to
gastrointestinal
tract
disorders
that
ultimately
impact
host
because
abnormal
microbial
metabolites
stimulate
trigger
physiologic
reactions
body.
Intestinal
a
change
bidirectional
relationship
between
CNS
GM,
which
is
linked
pathogenesis
neurodevelopmental
neurological
disorders.
Increasing
preclinical
clinical
studies/evidence
indicate
microbes
are
possible
susceptibility
factor
for
progression
disorders,
including
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
multiple
sclerosis
(MS)
autism
spectrum
disorder
(ASD).
In
this
review,
we
discuss
crucial
connection
system,
biological
systems
contribution
microbiota-related
Journal of Inflammation Research,
Journal Year:
2022,
Volume and Issue:
Volume 15, P. 6213 - 6230
Published: Nov. 1, 2022
Abstract:
The
gut
microbiota
is
the
most
abundant
and
diverse
in
human
body
vagus
nerve
widely
distributed
complex
body,
both
of
them
are
essential
maintaining
homeostasis.
important
phenomenon
how
they
coordinate
to
regulate
functions,
which
has
attracted
great
attention
scientists.
academic
literature
on
correlation
with
a
host
intestinal
diseases
even
systemic
revealed
bidirectional
communication
between
brain,
can
be
carried
out
via
multiple
patterns.
In
review,
firstly,
we
have
general
overview
microbiota-brain
axis.
Secondly,
according
distribution
characteristics
nerve,
analyzed
summarized
its
function
tract.
At
same
time,
underlying
mechanism
some
behavior
changes
such
as
depressive
anxiety-like
behaviors
related
neurodegenerative
caused
by
microecological
environment
disorders,
then
also
inconsistency
experimental
evidence
order
propose
novel
strategies
for
clinical
practice.
Keywords:
axis,
microbiota,
behavior,
