Models of heterogeneous dopamine signaling in an insect learning and memory center

PLoS Computational Biology, Journal Year: 2021, Volume and Issue: 17(8), P. e1009205 - e1009205

Published: Aug. 10, 2021

The Drosophila mushroom body exhibits dopamine dependent synaptic plasticity that underlies the acquisition of associative memories. Recordings neurons in this system have identified signals related to external reinforcement such as reward and punishment. However, other factors including locomotion, novelty, expectation, internal state also recently been shown modulate neurons. This heterogeneity is at odds with typical modeling approaches which these are assumed encode a global, scalar error signal. How coordinated presence heterogeneity? We develop approach infers pattern activity sufficient solve defined behavioral tasks, given architectural constraints informed by knowledge circuitry. Model exhibit diverse tuning task parameters while nonetheless producing coherent learned behaviors. Notably, prediction emerges mode population distributed across Our results provide mechanistic framework accounts for during learning behavior.

Language: Английский

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A persistent behavioral state enables sustained predation of humans by mosquitoes

eLife, Journal Year: 2022, Volume and Issue: 11

Published: May 12, 2022

Predatory animals pursue prey in a noisy sensory landscape, deciding when to continue or abandon their chase. The mosquito Aedes aegypti is micropredator that first detects humans at distance through cues such as carbon dioxide. As nears its target, it senses more proximal body heat guide meal of blood. How long the search for blood continues after initial detection human not known. Here, we show 5 s optogenetic pulse fictive dioxide induced persistent behavioral state female mosquitoes lasted than 10 min. This highly specific females searching and was recently blood-fed males, who do feed on In males lack gene fruitless , which controls social behaviors other insects, long-lasting behavior response resembling predatory females. Finally, triggered by enabled engorge mimic offered up 14 min stimulus. Our results demonstrate internal allows integrate multiple over timescales, an ability key success apex humans.

Language: Английский

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Insect transient receptor potential vanilloid channels as potential targets of insecticides

Developmental & Comparative Immunology, Journal Year: 2023, Volume and Issue: 148, P. 104899 - 104899

Published: July 31, 2023

Language: Английский

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Neuroarchitecture of the central complex of the desert locust: Tangential neurons

The Journal of Comparative Neurology, Journal Year: 2019, Volume and Issue: 528(6), P. 906 - 934

Published: Oct. 18, 2019

Abstract The central complex (CX) comprises a group of midline neuropils in the insect brain, consisting protocerebral bridge (PB), upper (CBU) and lower division (CBL) body pair globular noduli. It receives prominent input from visual system plays major role spatial orientation animals. Vertical slices horizontal layers CX are formed by columnar, tangential, pontine neurons. While columnar neurons have been analyzed detail, especially fruit fly desert locust, understanding organization tangential cells is still rudimentary. As basis for future functional studies, we studied morphologies locust Schistocerca gregaria . Intracellular dye injections revealed 43 different types neuron, 8 PB, 5 CBL, 24 CBU, 2 noduli, 4 innervating multiple substructures. Cell bodies these were located 11 clusters cell rind. Judging presence fine versus beaded terminals, vast majority provide into CX, lateral (LX), superior protocerebrum, posterior slope, other surrounding brain areas, but not directly mushroom bodies. Connections largely subunit‐ partly layer‐specific. No direct connections found between CBU CBL. Instead, both subdivisions connected parallel with PB distinct

Language: Английский

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Spatial Comparisons of Mechanosensory Information Govern the Grooming Sequence in Drosophila

Current Biology, Journal Year: 2020, Volume and Issue: 30(6), P. 988 - 1001.e4

Published: March 1, 2020

Animals integrate information from different sensory modalities, body parts, and time points to inform behavioral choice, but the relevant comparisons underlying neural circuits are still largely unknown. We use grooming behavior of Drosophila melanogaster as a model investigate that govern motor sequence. Flies perform movements spontaneously, when covered with dust, they clean their bodies following an anterior-to-posterior After investigating modalities could detect we focus on mechanosensory bristle neurons, whose optogenetic activation induces similar Computational modeling predicts higher input strength head will cause anterior occur first. test this prediction using competition assay whereby two targeted light beams independently activate neurons parts. find initial choice movement is determined by ratio inputs In dust-covered flies, change result successful cleaning movements. Simulations our suggest results in sequence progression. One possibility flies frequent between posterior inputs, changing ratios drive choices. Alternatively, may track temporal given part measure effectiveness. The first hypothesis supported experiments: iterative spatial parts essential for organizing

Language: Английский

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