Ventral tegmental area interneurons revisited: GABA and glutamate projection neurons make local synapses DOI Creative Commons

Lucie Oriol,

Melody Chao,

Grace J Kollman

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 8, 2024

Abstract The ventral tegmental area (VTA) contains projection neurons that release the neurotransmitters dopamine, GABA, and/or glutamate from distal synapses. VTA also GABA synapse locally on to dopamine neurons, synapses widely credited a population of so-called interneurons. Interneurons in cortex, striatum, and elsewhere have well-defined morphological features, physiological properties, molecular markers, but such features not been clearly described VTA. Indeed, there is scant evidence local originate separate populations neurons. In this study we tested whether several markers expressed non-dopamine are selective interneurons, defined as distally. Challenging previous assumptions, found genetically by expression parvalbumin, somatostatin, neurotensin, or mu-opioid receptor project known targets including nucleus accumbens, pallidum, lateral habenula, prefrontal cortex. Moreover, provide make functional inhibitory excitatory within These findings suggest collaterals could mediate functions prior attributed This underscores need for refined understanding connectivity explain how heterogeneous circuits diverse related reward, motivation, addiction. Significance statement key regulators considered central mechanisms which opioids other drugs abuse can induce Conventionally, these abundant VTA, it unclear if represent populations. We enriched Mu-opioid receptor, thus interneuron markers. collateralize where they data challenge notion only serve previously

Language: Английский

Brain circuits for pain and its treatment DOI
Nicole Mercer Lindsay, Chong Chen, Gadi Gilam

et al.

Science Translational Medicine, Journal Year: 2021, Volume and Issue: 13(619)

Published: Nov. 10, 2021

Understanding the organization of brain’s pain circuits is critical for developing effective treatments patients suffering from chronic pain.

Language: Английский

Citations

149
Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain DOI Creative Commons
Kaitlin C. Reeves, Nikhil Shah, Braulio Muñoz

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2022, Volume and Issue: 15

Published: June 15, 2022

Opioids mediate their effects via opioid receptors: mu, delta, and kappa. At the neuronal level, receptors are generally inhibitory, presynaptically reducing neurotransmitter release postsynaptically hyperpolarizing neurons. However, receptor-mediated regulation of function synaptic transmission is not uniform in expression pattern mechanism across brain. The localization within specific cell types neurocircuits determine that endogenous exogenous opioids have on brain function. In this review we will explore similarities differences neurotransmission different regions. We discuss how future studies can consider potential cell-type, regional, neural pathway-specific order to better understand modulate

Language: Английский

Citations

83
A photoswitchable GPCR-based opsin for presynaptic inhibition DOI Creative Commons
Bryan A. Copits,

Raaj Gowrishankar,

Patrick O’Neill

et al.

Neuron, Journal Year: 2021, Volume and Issue: 109(11), P. 1791 - 1809.e11

Published: May 11, 2021

Language: Английский

Citations

81
A glutamatergic DRN–VTA pathway modulates neuropathic pain and comorbid anhedonia-like behavior in mice DOI Creative Commons
Xinyue Wang,

Wen-Bin Jia,

Xiang Xu

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Aug. 23, 2023

Chronic pain causes both physical suffering and comorbid mental symptoms such as anhedonia. However, the neural circuits molecular mechanisms underlying these maladaptive behaviors remain elusive. Here using a mouse model, we report pathway from vesicular glutamate transporter 3 neurons in dorsal raphe nucleus to dopamine ventral tegmental area (VGluT3DRN→DAVTA) wherein population-level activity response innocuous mechanical stimuli sucrose consumption is inhibited by chronic neuropathic pain. Mechanistically, dampens VGluT3DRN → DAVTA glutamatergic transmission excitability. activation alleviates anhedonia-like behavior (CAB) releasing glutamate, which subsequently promotes DA release accumbens medial shell (NAcMed) produces analgesic anti-anhedonia effects via D2 D1 receptors, respectively. In addition, inhibition pain-like reflexive hypersensitivity intact mice. These findings reveal crucial role for D2/D1NAcMed establishing modulating CAB.

Language: Английский

Citations

26
The contribution of periaqueductal gray in the regulation of physiological and pathological behaviors DOI Creative Commons
Hui Zhang, Zhe Zhu, Wei‐Xiang Ma

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: April 8, 2024

Periaqueductal gray (PAG), an integration center for neuronal signals, is located in the midbrain and regulates multiple physiological pathological behaviors, including pain, defensive aggressive anxiety depression, cardiovascular response, respiration, sleep-wake behaviors. Due to different neuroanatomical connections functional characteristics of four columns PAG, subregions PAG synergistically regulate various instinctual In current review, we summarized role possible neurobiological mechanism regulation anxiety, depression from perspective up-down circuits PAG. Furthermore, proposed potential clinical applications Knowledge these aspects will give us a better understanding key behaviors provide directions future treatments.

Language: Английский

Citations

16
Cues conditioned to withdrawal and negative reinforcement: Neglected but key motivational elements driving opioid addiction DOI Creative Commons
Caroline B. Pantazis,

Luis Antonio Pérez González,

Brendan J. Tunstall

et al.

Science Advances, Journal Year: 2021, Volume and Issue: 7(15)

Published: April 7, 2021

Cues associated with negative reinforcement can stimulate relapse and contribute to opioid use disorder.

Language: Английский

Citations

49
Low-intensity ultrasound ameliorates brain organoid integration and rescues microcephaly deficits DOI
Xiaohong Li,

Di Guo,

Long‐Qing Chen

et al.

Brain, Journal Year: 2024, Volume and Issue: 147(11), P. 3817 - 3833

Published: May 13, 2024

Abstract Human brain organoids represent a remarkable platform for modelling neurological disorders and promising repair approach. However, the effects of physical stimulation on their development integration remain unclear. Here, we report that low-intensity ultrasound significantly increases neural progenitor cell proliferation neuronal maturation in cortical organoids. Histological assays single-cell gene expression analyses revealed improves Following organoid grafts transplantation into injured somatosensory cortices adult mice, longitudinal electrophysiological recordings histological ultrasound-treated undergo advanced maturation. They also exhibit enhanced pain-related gamma-band activity more disseminated projections host than untreated groups. Finally, ameliorates neuropathological deficits microcephaly model. Hence, advances organoids, providing strategy treating neurodevelopmental repairing damage.

Language: Английский

Citations

5
The rostromedial tegmental (RMTg) “brake” on dopamine and behavior: A decade of progress but also much unfinished work DOI Creative Commons
Thomas C. Jhou

Neuropharmacology, Journal Year: 2021, Volume and Issue: 198, P. 108763 - 108763

Published: Aug. 22, 2021

Language: Английский

Citations

32
Shared Mechanisms of GABAergic and Opioidergic Transmission Regulate Corticolimbic Reward Systems and Cognitive Aspects of Motivational Behaviors DOI Creative Commons
Oveis Hosseinzadeh Sahafi, Maryam Sardari, Sakineh Alijanpour

et al.

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(5), P. 815 - 815

Published: May 17, 2023

The functional interplay between the corticolimbic GABAergic and opioidergic systems plays a crucial role in regulating reward system cognitive aspects of motivational behaviors leading to development addictive disorders. This review provides summary shared mechanisms transmission, which modulate activity dopaminergic neurons located ventral tegmental area (VTA), central hub mechanisms. comprehensively covers neuroanatomical neurobiological inhibitory that express opioid receptors, act as modulators transmission. presence GABA receptors on same allows for modulation area, key brain. colocalization their immunochemical markers can provide comprehensive understanding clinicians researchers, revealing neuronal circuits contribute system. Moreover, this highlights importance transmission-induced neuroplasticity under receptors. It discusses interactive reinforcement learning, network oscillation, aversive behaviors, local feedback or feedforward inhibitions Understanding these may lead new therapeutic approaches addiction, reward-related disorders, drug-induced impairment.

Language: Английский

Citations

12
The Periaqueductal Gray and Its Extended Participation in Drug Addiction Phenomena DOI
Priscila Vázquez-León, Abraham Miranda-Páez, Jesús Chávez‐Reyes

et al.

Neuroscience Bulletin, Journal Year: 2021, Volume and Issue: 37(10), P. 1493 - 1509

Published: July 24, 2021

Language: Английский

Citations

25