Biological Psychiatry,
Journal Year:
2023,
Volume and Issue:
95(6), P. 592 - 600
Published: Nov. 30, 2023
Neuroplasticity,
or
activity-dependent
neuronal
change,
is
a
crucial
mechanism
underlying
the
mechanisms
of
effect
many
therapies
for
neuropsychiatric
disorders,
one
which
repetitive
transcranial
magnetic
stimulation
(rTMS).
Understanding
neuroplastic
effects
rTMS
at
different
biological
scales
and
on
timescales
how
interact
with
each
other
can
help
us
understand
in
clinical
populations
offers
potential
to
improve
treatment
outcomes.
Several
decades
research
fields
neuroimaging
blood
biomarkers
increasingly
showing
its
relevance,
allowing
measurement
synaptic,
functional,
structural
changes
involved
neuroplasticity
humans.
In
this
narrative
review,
we
describe
evidence
rTMS-induced
multiple
levels
nervous
system,
focus
psychiatric
disorders.
We
also
relationship
between
effects,
discuss
methods
optimize
neuroplasticity,
identify
future
opportunities
area.
Biological Psychiatry,
Journal Year:
2021,
Volume and Issue:
90(2), P. 128 - 136
Published: May 14, 2021
Neurotrophic
factors,
particularly
BDNF
(brain-derived
neurotrophic
factor),
have
been
associated
with
depression
and
antidepressant
drug
action.
A
variety
of
preclinical
clinical
studies
implicated
impaired
signaling
through
its
receptor
TrkB
(neurotrophic
tyrosine
kinase
2)
in
the
pathophysiology
mood
disorders,
but
many
initial
findings
not
fully
supported
by
more
recent
meta-analyses,
both
basic
research
is
needed.
In
contrast,
increased
expression
has
repeatedly
mechanisms
typical
rapid-acting
drugs,
started
to
elucidate
which
antidepressants
regulate
signaling.
a
critical
regulator
various
types
neuronal
plasticities
brain,
plasticity
increasingly
connected
Although
some
equivocal
data
exist,
hypothesis
connection
between
factors
disorders
action
recently
further
strengthened
converging
evidence
from
reviewed
here.
Nature Communications,
Journal Year:
2020,
Volume and Issue:
11(1)
Published: Dec. 22, 2020
Abstract
Ketamine
produces
immediate
antidepressant
effects
and
has
inspired
research
into
next-generation
treatments.
also
short
term
dissociative
effects,
in
which
individuals
report
altered
consciousness
perceptions
of
themselves
their
environment.
However,
whether
ketamine’s
side
are
necessary
for
its
remains
unclear.
This
perspective
examines
the
relationship
between
acute
longer-lasting
response
to
ketamine
other
N-methyl-D-aspartate
(NMDA)
receptor
antagonists.
Presently,
literature
does
not
support
conclusion
that
dissociation
is
ketamine.
further
work
needed
explore
at
molecular,
biomarker,
psychological
levels.
Neuropsychopharmacology,
Journal Year:
2023,
Volume and Issue:
49(1), P. 41 - 50
Published: July 24, 2023
Abstract
Ketamine
is
an
open
channel
blocker
of
ionotropic
glutamatergic
N
-Methyl-
D
-Aspartate
(NMDA)
receptors.
The
discovery
its
rapid
antidepressant
effects
in
patients
with
depression
and
treatment-resistant
fostered
novel
effective
treatments
for
mood
disorders.
This
not
only
provided
new
insight
into
the
neurobiology
disorders
but
also
uncovered
fundamental
synaptic
plasticity
mechanisms
that
underlie
treatment.
In
this
review,
we
discuss
key
clinical
aspects
ketamine’s
effect
as
a
rapidly
acting
antidepressant,
circuit
underlying
action,
well
how
these
perspectives
practice
synapse
biology
form
road
map
future
studies
aimed
at
more
neuropsychiatric
ACS Chemical Neuroscience,
Journal Year:
2023,
Volume and Issue:
14(3), P. 468 - 480
Published: Jan. 11, 2023
Psilocybin
is
a
psychedelic
with
therapeutic
potential.
While
there
growing
evidence
that
psilocybin
exerts
its
beneficial
effects
through
enhancing
neural
plasticity,
the
exact
brain
regions
involved
are
not
completely
understood.
Determining
impact
of
on
plasticity-related
gene
expression
throughout
can
broaden
our
understanding
circuits
in
psychedelic-evoked
plasticity.
In
this
study,
whole-brain
serial
two-photon
microscopy
and
light
sheet
were
employed
to
map
immediate
early
gene,
c-Fos,
male
female
mice.
The
drug-induced
c-Fos
following
administration
was
compared
subanesthetic
ketamine
saline
control.
produced
acutely
comparable
elevations
numerous
regions,
including
anterior
cingulate
cortex,
locus
coeruleus,
primary
visual
central
basolateral
amygdala,
medial
lateral
habenula,
claustrum.
Select
exhibited
drug-preferential
differences,
such
as
dorsal
raphe
insular
cortex
for
CA1
subfield
hippocampus
ketamine.
To
gain
insights
into
contributions
receptors
cell
types,
maps
related
brain-wide
situ
hybridization
data.
transcript
analyses
showed
endogenous
levels
Biochemistry,
Journal Year:
2022,
Volume and Issue:
61(3), P. 127 - 136
Published: Jan. 21, 2022
In
addition
to
producing
profound
subjective
effects
following
acute
administration,
psychedelic
compounds
can
induce
beneficial
behavioral
changes
relevant
the
treatment
of
neuropsychiatric
disorders
that
last
long
after
have
been
cleared
from
body.
One
hypothesis
with
potential
explain
remarkable
enduring
psychedelics
is
related
their
abilities
promote
structural
and
functional
neuroplasticity
in
prefrontal
cortex
(PFC).
A
hallmark
many
stress-related
diseases,
including
depression,
post-traumatic
stress
disorder
(PTSD),
addiction,
atrophy
neurons
PFC.
Psychedelics
appear
be
particularly
effective
catalysts
for
growth
these
key
neurons,
ultimately
leading
restoration
synaptic
connectivity
this
critical
brain
region.
Furthermore,
evidence
suggests
hallucinogenic
are
not
directly
linked
ability
neuroplasticity.
If
we
develop
improved
alternatives
treating
must
fully
characterize
molecular
mechanisms
give
rise
psychedelic-induced
Here,
I
review
our
current
understanding
biochemical
signaling
pathways
activated
by
neuroplasticity-promoting
molecules,
an
emphasis
on
unanswered
questions.
Journal of Neuroscience,
Journal Year:
2023,
Volume and Issue:
43(6), P. 1038 - 1050
Published: Jan. 3, 2023
Ketamine
is
a
well-characterized
NMDA
receptor
(NMDAR)
antagonist,
although
the
relevance
of
this
pharmacology
to
its
rapid
(within
hours
administration)
antidepressant
actions,
which
depend
on
mechanisms
convergent
with
strengthening
excitatory
synapses,
unclear.
Activation
synaptic
NMDARs
necessary
for
induction
canonical
long-term
potentiation
(LTP)
leading
sustained
expression
increased
strength.
We
tested
hypothesis
that
effects
requires
NMDAR
activation,
by
using
behavioral
pharmacology,
western
blot
quantification
hippocampal
synaptoneurosomal
protein
levels,
and
Annual Review of Medicine,
Journal Year:
2023,
Volume and Issue:
75(1), P. 129 - 143
Published: Sept. 20, 2023
Major
depressive
disorder
(MDD)
is
a
leading
cause
of
suicide
in
the
world.
Monoamine-based
antidepressant
drugs
are
primary
line
treatment
for
this
mental
disorder,
although
delayed
response
and
incomplete
efficacy
some
patients
highlight
need
improved
therapeutic
approaches.
Over
past
two
decades,
ketamine
has
shown
rapid
onset
with
sustained
(up
to
several
days)
effects
whose
MDD
not
responded
conventional
drugs.
Recent
preclinical
studies
have
started
elucidate
underlying
mechanisms
ketamine's
properties.
Herein,
we
describe
compare
recent
clinical
findings
provide
broad
perspective
relevant
action
ketamine.
