Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102743 - 102743
Published: April 1, 2025
Language: Английский
PLoS Computational Biology, Journal Year: 2025, Volume and Issue: 21(2), P. e1012247 - e1012247
Published: Feb. 13, 2025
The amygdala responds to a large variety of socially and emotionally salient environmental interoceptive stimuli. context in which these stimuli occur determines their social emotional significance. In canonical neurophysiological studies, the fast-paced succession events induce phasic changes neural activity. During inter-trial intervals, activity is expected return stable featureless level spontaneous activity, often called baseline. previous studies we found that context, such as presence partner, induces brain states can transcend be recovered from spontaneous, firing rate neurons. Indeed, rates neurons are different during blocks gentle grooming touches delivered by trusted non-social airflow computer-controlled air valve. Here, examine local field potentials (LFPs) recorded periods determine whether information about extracted signals. We vs. present potential between application stimuli, machine learning techniques reliably decode spectrograms LFPs. No significant differences were detected nuclei receive direct or indirect inputs areas prefrontal cortex known coordinate flexible, context-dependent behaviors. lack nuclear specificity suggests context-related synaptic arise shared source, possibly inputs, signal physiological state body tactile stimulation.
Language: Английский
Citations
0
Springer eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 55 - 102
Published: Jan. 1, 2025
Citations
0
Neuron, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
Neuron, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Food intake serves to maintain energy homeostasis; however, overeating can result in obesity, which is associated with serious health complications. In this review, we explore the intricate relationship between overeating, and underlying neurobiological mechanisms. We review homeostatic hedonic feeding systems, highlighting role of hypothalamus reward systems controlling food balance. Dysregulation both these leads as seen genetic syndromes environmental models affecting appetite regulation when consuming highly palatable food. The concept "food addiction" examined, drawing parallels drug addiction. discuss cellular substrate for addiction-related behavior current pharmacological obesity treatments-in particular, GLP-1 receptor agonists-showcasing synaptic plasticity context exposure. A comprehensive model integrating insights from addiction research proposed guide effective interventions maladaptive behaviors. Ultimately, unraveling basis holds promise addressing pressing public issue obesity.
Language: Английский
Citations
0
Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102743 - 102743
Published: April 1, 2025
Language: Английский
Citations
0