Spiking activity in the visual thalamus is coupled to pupil dynamics across temporal scales

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2021, Volume and Issue: unknown

Published: April 30, 2021

Abstract The processing of sensory information, even at early stages, is influenced by the internal state animal. Internal states, such as arousal, are often characterized relating neural activity to a single “level” defined behavioral indicator pupil size. In this study, we expand understanding arousal-related modulations in systems uncovering multiple timescales dynamics and their relationship activity. Specifically, observed coupling between spiking mouse dorsal lateral geniculate nucleus (dLGN) thalamus across spanning three orders magnitude, from seconds minutes. Throughout all these timescales, two distinct patterns – tonic spikes bursts preferred opposing phases dynamics. This multi-scale captures those captured size per se , transitions locomotion quiescence, or saccadic eye movements. Furthermore, persisted during viewing naturalistic movie, where it contributed differences how visual information was encoded. We conclude that dLGN arousal processes associated with occurring simultaneously broad range implications for transfer cortex.

Language: Английский

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Cortico-thalamo-cortical interactions modulate electrically evoked EEG responses in mice

Published: Feb. 9, 2023

Perturbational complexity analysis predicts the presence of consciousness in volunteers and patients by stimulating brain with brief pulses, recording electroencephalographic ( EEG ) responses, computing their spatiotemporal complexity. We examined underlying neural circuits mice directly cortex while Neuropixels probes during wakefulness isoflurane anesthesia. When are awake, stimulation deep cortical layers reliably evokes locally a pulse excitation, followed bi-phasic sequence 120 ms profound off period rebound excitation. A similar pattern, partially attributed to burst spiking, is seen thalamic nuclei, associated pronounced late component evoked EEG. infer that cortico-thalamo-cortical interactions drive long-lasting signals elicited awake state. The EEG, reduced running absent

Language: Английский

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Cortico-thalamo-cortical interactions modulate electrically evoked EEG responses in mice

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: July 23, 2022

ABSTRACT Perturbational complexity analysis predicts the presence of consciousness in volunteers and patients by stimulating brain with brief pulses, recording electroencephalographic ( EEG ) responses, computing their spatiotemporal complexity. We examined underlying neural circuits mice directly cortex while Neuropixels probes during wakefulness isoflurane anesthesia. When are awake, stimulation deep cortical layers reliably evokes locally a pulse excitation, followed bi-phasic sequence 120 ms profound off period rebound excitation. A similar pattern, partially attributed to burst spiking, is seen thalamic nuclei, associated pronounced late component evoked EEG. infer that cortico-thalamo-cortical interactions drive long-lasting signals elicited awake state. The EEG, reduced running absent

Language: Английский

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Rule-based modulation of a sensorimotor transformation across cortical areas

Published: May 20, 2024

Flexible responses to sensory stimuli based on changing rules are critical for adapting a dynamic environment. However, it remains unclear how the brain encodes rule information and uses this guide behavioral stimuli. Here, we made single-unit recordings while head-fixed mice performed cross-modal selection task in which they switched between two different blocks of trials: licking response tactile applied whisker rejecting visual stimuli, or Along cortical sensorimotor processing stream including primary (S1) secondary (S2) somatosensory areas, medial (MM) anterolateral (ALM) motor single-trial activity individual neurons distinguished both prior stimulus. Variable rule-dependent identical could principle occur via appropriate configuration pre-stimulus preparatory states neural population, would shape subsequent response. We hypothesized that populations S1, S2, MM ALM show were set manner cause according current rule. This hypothesis was supported areas by findings (1) be decoded from population MM; (2) subspaces containing differed rules; (3) optogenetic disruption within impaired performance. Our indicate flexible an action input can cortex.Task reflected cortices.Neural signals depend rule.Motor tracks switches is required rule-guided behavior.

Language: Английский

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At the onset of active whisking, the input layer of barrel cortex exhibits a 24 h window of increased excitability that depends on prior experience.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 5, 2024

Abstract The development of motor control over sensory organs is a critical milestone in processing, enabling active exploration and shaping the environment. However, whether onset organ directly influences corresponding cortices remains unknown. Here, we exploit late whisking behavior mice to address this question somatosensory system. Using ex vivo electrophysiology, discovered transient increase intrinsic excitability excitatory neurons layer IV barrel cortex, which processes whisker input, precisely coinciding with at postnatal day 14 (P14). This neuronal gain was specific IV, independent changes synaptic strength, required prior experience. Strikingly, effect not observed II/III cortex or visual upon eye opening, suggesting unique interaction between sensing thalamocortical input Predictive modeling indicated that membrane conductances alone could reliably distinguish P14 but whisker-deprived hemispheres. Our findings demonstrate an experience-dependent, lamina-specific refinement tightly linked emergence whisking. thalamic coincides period for plasticity downstream layers, role facilitating cortical maturation processing. Together, our results provide evidence direct offering new insights into experience-dependent systems. These have broad implications understanding interplay development, how mechanisms perception cooperate behavior.

Language: Английский

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