Decision-making dynamics are predicted by arousal and uninstructed movements

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: March 2, 2023

During sensory-guided behavior, an animal's decision-making dynamics unfold through sequences of distinct performance states, even while stimulus-reward contingencies remain static. Little is known about the factors that underlie these changes in task performance. We hypothesize can be predicted by externally observable measures, such as uninstructed movements and arousal. Here, combining behavioral experiments mice with computational modeling, we uncovered lawful relationships between transitions strategic states arousal movements. Using hidden Markov models applied to choices during sensory discrimination tasks, found animals fluctuate minutes-long optimal, sub-optimal disengaged states. Optimal state epochs were intermediate levels, reduced variability, pupil diameter, along variability face locomotion. Our results demonstrate behaviors predict optimal suggest regulate their

Language: Английский

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How ‘visual’ is the visual cortex? The interactions between the visual cortex and other sensory, motivational and motor systems as enabling factors for visual perception

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2023, Volume and Issue: 378(1886)

Published: Aug. 7, 2023

The definition of the visual cortex is primarily based on evidence that lesions this area impair perception. However, does not exclude may process more information than retinal origin alone, or other brain structures contribute to vision. Indeed, research across past decades has shown non-visual information, such as neural activity related reward expectation and value, locomotion, working memory sensory modalities, can modulate primary cortical responses inputs. Nevertheless, function poorly understood. Here we review recent evidence, coming from studies in rodents, arguing motor effects play a role processing itself, for instance disentangling direct auditory sound-evoked orofacial movement. These findings are placed broader framework casting vision terms predictive under control frontal, reward- motor-related systems. In contrast prevalent notion exclusively constructed by system, propose percepts generated larger network-the extended system-spanning cortices, supramodal areas frontal This article part theme issue 'Decision processes multisensory perception'.

Language: Английский

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Signatures of task learning in neural representations

Current Opinion in Neurobiology, Journal Year: 2023, Volume and Issue: 83, P. 102759 - 102759

Published: Sept. 12, 2023

Language: Английский

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Analysis methods for large-scale neuronal recordings

Science, Journal Year: 2024, Volume and Issue: 386(6722)

Published: Nov. 7, 2024

Simultaneous recordings from hundreds or thousands of neurons are becoming routine because innovations in instrumentation, molecular tools, and data processing software. Such can be analyzed with science methods, but it is not immediately clear what methods to use how adapt them for neuroscience applications. We review, categorize, illustrate diverse analysis neural population describe these have been used make progress on longstanding questions neuroscience. review a variety approaches, ranging the mathematically simple complex, exploratory hypothesis-driven, recently developed more established methods. also some common statistical pitfalls analyzing large-scale data.

Language: Английский

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Spontaneous mesoscale calcium dynamics reflect the development of the modular functional architecture of the mouse cerebral cortex

NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121088 - 121088

Published: Feb. 1, 2025

Language: Английский

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