Sleep—A brain-state serving systems memory consolidation

Neuron, Journal Year: 2023, Volume and Issue: 111(7), P. 1050 - 1075

Published: April 1, 2023

Language: Английский

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Consciousness and sleep

Neuron, Journal Year: 2024, Volume and Issue: 112(10), P. 1568 - 1594

Published: May 1, 2024

Language: Английский

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Stress induces behavioral abnormalities by increasing expression of phagocytic receptor MERTK in astrocytes to promote synapse phagocytosis

Immunity, Journal Year: 2023, Volume and Issue: 56(9), P. 2105 - 2120.e13

Published: July 31, 2023

Childhood neglect and/or abuse can induce mental health conditions with unknown mechanisms. Here, we identified stress hormones as strong inducers of astrocyte-mediated synapse phagocytosis. Using in vitro, vivo, and human brain organoid experiments, showed that increased the expression Mertk phagocytic receptor astrocytes through glucocorticoid (GR). In post-natal mice, exposure to early social deprivation (ESD) specifically activated GR-MERTK pathway astrocytes, but not microglia. The excitatory post-synaptic density cortical regions was reduced ESD there an increase astrocytic engulfment these synapses. loss synapses, abnormal neuronal network activities, behavioral abnormalities mice were largely prevented by ablating GR or MERTK astrocytes. Our work reveals critical roles activation evoking stress-induced behaviors suggesting signaling a therapeutic target for conditions.

Language: Английский

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Sleep and the hypothalamus

Science, Journal Year: 2023, Volume and Issue: 382(6669), P. 405 - 412

Published: Oct. 26, 2023

Neural substrates of wakefulness, rapid eye movement sleep (REMS), and non-REMS (NREMS) in the mammalian hypothalamus overlap both anatomically functionally with cellular networks that support physiological behavioral homeostasis. Here, we review roles neurons homeostatic control thermoregulation or goal-oriented behaviors during wakefulness. We address how hypothalamic circuits involved opposing such as core body temperature compute conflicting information provide a coherent vigilance state. Finally, highlight some key unresolved questions challenges, promise more granular view molecular diversity underlying integrative role

Language: Английский

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How our understanding of memory replay evolves

Journal of Neurophysiology, Journal Year: 2023, Volume and Issue: 129(3), P. 552 - 580

Published: Feb. 8, 2023

Memory reactivations and replay, widely reported in the hippocampus cortex across species, have been implicated memory consolidation, planning, spatial skill learning. Technological advances electrophysiology, calcium imaging, human neuroimaging techniques enabled neuroscientists to measure large-scale neural activity with increasing spatiotemporal resolution provided opportunities for developing robust analytic methods identify replay. In this article, we first review a large body of historically important representative replay studies from animal literature. We then discuss our current understanding functions learning, consolidation further progress computational modeling that has contributed these improvements. Next, past present analyses their limitations challenges. Finally, looking ahead, some promising detecting nonstereotypical, behaviorally nondecodable structures recordings. argue seamless integration multisite recordings, real-time decoding, closed-loop manipulation experiments will be essential delineating role wide range cognitive motor functions.

Language: Английский

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Hypothalamic Supramammillary Control of Cognition and Motivation

Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 43(45), P. 7538 - 7546

Published: Nov. 8, 2023

The supramammillary nucleus (SuM) is a small region in the ventromedial posterior hypothalamus. SuM has been relatively understudied with much of prior focus being on its connection septo-hippocampal circuitry. Thus, most studies conducted until 21st century examined role hippocampal processes, such as theta rhythm and learning/memory. In recent years, “rediscovered” crucial hub for several behavioral cognitive including reward-seeking, exploration, social memory. Additionally, it shown to play significant roles plasticity adult neurogenesis. This review highlights findings from using cutting-edge systems neuroscience tools that have shed light these fascinating SuM.

Language: Английский

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Alzheimer’s disease and sleep disorders: a bidirectional relationship

Neuroscience, Journal Year: 2024, Volume and Issue: 557, P. 12 - 23

Published: Aug. 11, 2024

Alzheimer's disease (AD) is the most prevalent dementia, pathologically featuring abnormal accumulation of amyloid-β (Aβ) and hyperphosphorylated tau, while sleep, divided into rapid eye movement sleep (REM) nonrapid (NREM), plays a key role in consolidating social spatial memory. Emerging evidence has revealed that disorders such as circadian disturbances disruption neuronal rhythm activity are considered both candidate risks consequence AD, suggesting bidirectional relationship between AD. This review will firstly grasp basic knowledge AD pathogenesis, then highlight macrostructural microstructural alteration along with progression, explain interaction Aβ which two critical neuropathological processes well neuroinflammation finally introduce several methods enhancement strategies to reduce AD-associated neuropathology. Although theories about relevant therapeutic mice have been developed recent years, human still limited. More studies on how effectively ameliorate pathology patients by what specific roles play needed.

Language: Английский

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Which structure generates paradoxical (REM) sleep: The brainstem, the hypothalamus, the amygdala or the cortex?

Sleep Medicine Reviews, Journal Year: 2024, Volume and Issue: 74, P. 101907 - 101907

Published: Jan. 29, 2024

Paradoxical or Rapid eye movement (REM) sleep (PS) is a state characterized by REMs, EEG activation and muscle atonia. In this review, we discuss the contribution of brainstem, hypothalamic, amygdalar cortical structures in PS genesis. We propose that atonia during due to glutamatergic neurons localized pontine sublaterodorsal tegmental nucleus (SLD) projecting glycinergic/GABAergic pre-motoneurons ventro-medial medulla (vmM). The SLD PS-on are inactivated wakefulness slow-wave PS-off GABAergic ventrolateral periaqueductal gray (vPAG) adjacent deep mesencephalic reticular nucleus. Melanin concentrating hormone (MCH) posterior hypothalamus would inhibit these initiate state. Finally, few limbic claustrum supramammillary as well basolateral amygdala also contribute expression. Accumulating evidence indicates plays role memory consolidation communicate PS-generating need for process memory. summary, generation controlled distributed from cortex medullary level brain.

Language: Английский

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A potentiation of REM sleep-active neurons in the lateral habenula may be responsible for the sleep disturbance in depression

Current Biology, Journal Year: 2024, Volume and Issue: 34(15), P. 3287 - 3300.e6

Published: June 28, 2024

Language: Английский

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Diverse roles of pontine NPS-expressing neurons in sleep regulation

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(9)

Published: Feb. 21, 2024

Neuropeptide S (NPS) was postulated to be a wake-promoting neuropeptide with unknown mechanism, and mutation in its receptor (NPSR1) causes the short sleep duration trait humans. We investigated role of different NPS + nuclei sleep/wake regulation. Loss-of-function chemogenetic studies revealed that neurons parabrachial nucleus (PB) are wake-promoting, whereas peri-locus coeruleus (peri-LC) not important for modulation. Further, we found central gray pons (CGPn) strongly promotes sleep. Fiber photometry recordings showed wake-active CGPn wake/REM-sleep active PB peri-LC. Blocking NPS–NPSR1 signaling or knockdown Nps supported function pathway Together, these results reveal play dichotomous roles regulation at both molecular circuit levels.

Language: Английский

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