Rule-based modulation of a sensorimotor transformation across cortical areas DOI Open Access
Yi-Ting Chang, Eric A. Finkel, Duo Xu

et al.

Published: Dec. 28, 2023

Flexible responses to sensory stimuli based on changing rules are critical for adapting a dynamic environment. However, it remains unclear how the brain encodes rule information and uses this guide behavioral stimuli. Here, we made single-unit recordings while head-fixed mice performed cross-modal selection task in which they switched between two different blocks of trials: licking response tactile applied whisker rejecting visual stimuli, or Along cortical sensorimotor processing stream including primary (S1) secondary (S2) somatosensory areas, medial (MM) anterolateral (ALM) motor single-trial activity individual neurons distinguished both prior stimulus. Variable rule-dependent identical could principle occur via appropriate configuration pre-stimulus preparatory states neural population, would shape subsequent response. We hypothesized that populations S1, S2, MM ALM show were set manner cause according current rule. This hypothesis was supported areas by findings (1) be decoded from population MM; (2) subspaces containing differed stimulus during stimulus-evoked response; (3) optogenetic disruption within impaired performance. Our indicate flexible an action input can cortex.Task reflected cortices.Neural signals depend rule.Motor tracks switches is required rule-guided behavior.

Language: Английский

Radical flexibility of neural representation in frontoparietal cortex and the challenge of linking it to behaviour DOI Creative Commons
Y. Y. ZHENG, Runhao Lu, Alexandra Woolgar

et al.

Current Opinion in Behavioral Sciences, Journal Year: 2024, Volume and Issue: 57, P. 101392 - 101392

Published: April 20, 2024

While many brain networks are specialised for processing specific types of information, a network frontoparietal regions is engaged by wide range cognitive demands. Here, we review recent work highlighting the flexibility information coding in these regions, including their potential to differentiate variety different and dynamic selectivity that currently relevant. But does all decodable activity constitute behaviourally meaningful brain? Examining emerging methods, find direct link behaviour can be made some, but not all, information. The data suggest flexible resource suitable creating temporary arbitrary associations between aspects needed each task. However, tighter field-wide focus on decoding–behaviour relationships specify how this gives rise astounding human capacity thought action.

Language: Английский

Citations

5
Neuropsychological mechanisms of observational learning in human placebo effects DOI
Nandini Raghuraman, Jewel White,

Lakota Watson

et al.

Psychopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: May 14, 2024

Language: Английский

Citations

4
A transient high-dimensional geometry affords stable conjunctive subspaces for efficient action selection DOI Creative Commons
Atsushi Kikumoto, Apoorva Bhandari, Kazuhisa Shibata

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 1, 2024

Language: Английский

Citations

4
A Transient High-dimensional Geometry Affords Stable Conjunctive Subspaces for Efficient Action Selection DOI Creative Commons
Atsushi Kikumoto, Apoorva Bhandari, Kazuhisa Shibata

et al.

Published: June 11, 2023

Abstract Flexible action selection requires cognitive control mechanisms capable of mapping the same inputs to different output actions depending on context. From a neural state-space perspective, this representation that separates similar input states by Additionally, for be robust and time-invariant, information must stable in time, enabling efficient readout. Here, using EEG decoding methods, we investigate how geometry dynamics representations constrain flexible human brain. Participants performed context-dependent task. A forced response procedure probed trajectories. The result shows before successful responses, there is transient expansion representational dimensionality separated conjunctive subspaces. Further, stabilizes time window, with entry into stable, high-dimensional state predictive individual trial performance. These results establish brain needs over behavior.

Language: Английский

Citations

9
Sensorimotor environment but not task rule reconfigures population dynamics in rhesus monkey posterior parietal cortex DOI Creative Commons
Hao Guo, Shenbing Kuang, Alexander Gail

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 3, 2025

Primates excel at mapping sensory inputs flexibly onto motor outcomes. We asked if the neural dynamics to support context-sensitive sensorimotor generalizes or differs between different behavioral contexts that demand such flexibility. compared reaching under mirror-reversed vision, a case of adaptation modified environment (SE), with anti reaching, applying an abstract task rule (TR). While in monkey posterior parietal cortex show shifted initial states and non-aligned low-dimensional subspaces SE task, remapping is achieved overlapping TR task. A recurrent network model demonstrates how output constraints mimicking tasks are sufficient generate two fundamentally computational dynamics. conclude implement happens within existing repertoire dynamics, while compensation perturbed feedback requires exploration independent cortex. Context-dependent input key for goal-directed behavior. Here, authors brain achieves this without reconfiguring networks, depending on type context.

Language: Английский

Citations

0
Individual Differences in Belief Updating and Phasic Arousal Are Related to Psychosis Proneness DOI Creative Commons
Peter R. Murphy, Katarina Krkovic, Gina Monov

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 15, 2024

Abstract Many decisions entail the updating of beliefs about state environment, a process that may go awry in psychosis. When environments are subject to hidden changes their state, optimal belief requires non-linear modulation sensory evidence, which be subserved by pupil-linked, phasic arousal. Here, we analyzed behavior and pupil responses during evidence accumulation changing environment community sample human participants assessed subclinical psychotic experiences (psychosis proneness). Subjects most prone psychosis showed overall less flexible profiles, with diminished weighting late evidence. These same subjects also exhibited smaller reliable encoding computational variables governing adaptive updating. The observed arousal dynamics account for emergence cognitive biases psychopathology. Our results open new window on pathophysiology mental disorders.

Language: Английский

Citations

2
Individual differences in belief updating and phasic arousal are related to psychosis proneness DOI Creative Commons
Peter R. Murphy, Katarina Krkovic, Gina Monov

et al.

Communications Psychology, Journal Year: 2024, Volume and Issue: 2(1)

Published: Sept. 23, 2024

Many decisions entail the updating of beliefs about state environment by accumulating noisy sensory evidence. This form probabilistic reasoning may go awry in psychosis. Computational theory shows that optimal belief environments subject to hidden changes their requires a dynamic modulation evidence accumulation process. Recent empirical findings implicate transient responses pupil-linked central arousal systems individual samples this modulation. Here, we analyzed behavior and pupil during changing community sample human participants. We also assessed subclinical psychotic experiences (psychosis proneness). Participants most prone psychosis showed overall less flexible profiles, with diminished behavioral impact occurring late decision formation. These same individuals exhibited smaller reliable encoding computational variables governing updating. Our provide insights into cognitive physiological bases proneness open paths unraveling pathophysiology disorders.

Language: Английский

Citations

2
Radical flexibility of neural representation in frontoparietal cortex and the challenge of linking it to behaviour DOI Open Access
Y. Y. ZHENG, Runhao Lu, Alexandra Woolgar

et al.

Published: Feb. 2, 2024

While many brain networks are specialised for processing specific types of information, a network frontoparietal regions is engaged by wide range cognitive demands. Here we review recent work highlighting the flexibility information coding in these regions, including their potential to differentiate variety different and dynamic selectivity that currently relevant. But does all decodable activity constitute behaviourally meaningful brain? Examining emerging methods, find direct link behaviour can be made some, but not all, information. The data suggest flexible resource suitable creating temporary, arbitrary, associations between aspects needed each task. However, tighter field-wide focus on decoding-behaviour relationships specify how this gives rise astounding human capacity thought action.

Language: Английский

Citations

1
The human hypothalamus coordinates switching between different survival actions DOI Creative Commons
Jaejoong Kim, Sarah M. Tashjian, Dean Mobbs

et al.

PLoS Biology, Journal Year: 2024, Volume and Issue: 22(6), P. e3002624 - e3002624

Published: June 28, 2024

Comparative research suggests that the hypothalamus is critical in switching between survival behaviors, yet it unclear if this case humans. Here, we investigate role of human by introducing a paradigm where volunteers switch hunting and escape response to encounters with virtual predator or prey. Given small size low tissue contrast hypothalamus, used deep learning-based segmentation identify individual-specific its subnuclei as well an imaging sequence optimized for hypothalamic signal acquisition. Across 2 experiments, employed computational models identical structures explain internal movement generation processes associated escaping. Despite shared structure, exhibited significantly different parameter values escaping were accurately decodable just computing parameters processes. In experiment 2, multi-voxel pattern analyses (MVPA) showed hippocampus, periaqueductal gray encode behaviors while not encoding simple motor outside context. Furthermore, connectivity revealed network including how connected other regions network. Finally, model-based fMRI strong predictive optimal behavioral coordination after switching, especially when was synchronized amygdala. Our study first action organization switching.

Language: Английский

Citations

1
Linking Cognitive Integrity to Working Memory Dynamics in the Aging Human Brain DOI
Gina Monov,

Henrik Stein,

Leonie Klock

et al.

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(26), P. e1883232024 - e1883232024

Published: May 17, 2024

Aging is accompanied by a decline of working memory, an important cognitive capacity that involves stimulus-selective neural activity persists after stimulus presentation. Here, we unraveled memory dynamics in older human adults (male and female) including those diagnosed with mild impairment (MCI) using combination behavioral modeling, neuropsychological assessment, MEG recordings brain activity. Younger were studied modeling only. Participants performed visuospatial delayed match-to-sample task under systematic manipulation the delay distance between sample test stimuli. Their behavior (match/nonmatch decisions) was fit computational model permitting dissociation noise internal operations underlying performance from strategic decision threshold. Task accuracy decreased duration sample/test proximity. When distances small, committed more false alarms than younger adults. The explained participants' well. parameters reflecting (not threshold) correlated precision cortical measured during interval. uncovered increase specifically compared participants. Furthermore, MCI group, but not healthy controls, clinically assessed integrity. Our results are consistent idea stability contents deteriorates aging, manner linked to overall integrity individuals MCI.

Language: Английский

Citations

1