Repeated Exposure to Multiple Concurrent Stressors Alters Visual Processing in the Adult Posterior Parietal Cortex

Published: Jan. 1, 2024

Chronic stress is well known to erode cognitive functions. Yet, our understanding of how repeated exposure impacts one the fundamental bases cognition: sensory processing, remains limited. The posterior parietal cortex (PPC) a high order visual region, for its role in visually guided decision making, multimodal integration, attention, and working memory. Here, we used functional measures determine multiple concurrent stressors (RMS) affects processing PPC adult male mice. A longitudinal experimental design, repeatedly surveying same population neurons using vivo two-photon imaging, revealed that RMS disrupts balanced turnover responsive cells layer 2/3 PPC. Across population, RMS-induced changes responsiveness followed bimodal distribution suggesting idiosyncratic effects. In maintained their across recording sessions, found reduced response magnitudes. While did not observe stress-induced elimination excitatory synapses, noise correlation statistics indicated altered input neuronal population. impact was restricted evoked responses evident activity associated with locomotion onset. Together, results indicate despite no apparent synaptic reorganization, adulthood can disrupt PPC, effects showing remarkable individual variation.

Language: Английский

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Repeated exposure to multiple concurrent stressors alters visual processing in the adult posterior parietal cortex

Neurobiology of Stress, Journal Year: 2024, Volume and Issue: 31, P. 100660 - 100660

Published: July 1, 2024

Chronic stress is well known to erode cognitive functions. Yet, our understanding of how repeated exposure impacts one the fundamental bases cognition: sensory processing, remains limited. The posterior parietal cortex (PPC) a high order visual region, for its role in visually guided decision making, multimodal integration, attention, and working memory. Here, we used functional measures determine multiple concurrent stressors (RMS) affects processing PPC adult male mice. A longitudinal experimental design, repeatedly surveying same population neurons using

Language: Английский

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Primary auditory thalamus relays directly to cortical layer 1 interneurons

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 18, 2024

Inhibitory interneurons within cortical layer 1 (L1-INs) integrate inputs from diverse brain regions to modulate sensory processing and plasticity, but the that recruit these have not been identified. Here we used monosynaptic retrograde tracing whole-cell electrophysiology characterize thalamic onto two major subpopulations of L1-INs in mouse auditory cortex. We find vast majority unexpectedly arise ventral subdivision medial geniculate body (MGBv), tonotopically-organized primary thalamus. Moreover, receive robust functional MGBv are comparable those recorded L4 excitatory pyramidal neurons. Our findings identify a direct pathway thalamus L1-INs, suggesting uniquely positioned conveying precise information with top-down carrying about states learned associations.

Language: Английский

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Interneurons in learning and memory

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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Synaptic configuration and reconfiguration in the neocortex are spatiotemporally selective

Anatomical Science International, Journal Year: 2023, Volume and Issue: 99(1), P. 17 - 33

Published: Oct. 14, 2023

Abstract Brain computation relies on the neural networks. Neurons extend neurites such as dendrites and axons, contacts of these that form chemical synapses are biological basis signal transmissions in central nervous system. Individual neuronal outputs can influence other neurons within range axonal spread, while activities single be affected by afferents their somatodendritic fields. The morphological profile, therefore, binds functional role each neuron play. In addition, synaptic connectivity among displays preference based characteristics presynaptic postsynaptic neurons. Here, author reviews “spatial” “temporal” connection selectivity neocortex. histological description neocortical circuitry depends primarily classification cell types, development gene engineering techniques allows type-specific visualization axons well somata. Using genetic labeling particular populations combined with immunohistochemistry imaging at a subcellular spatial resolution, we revealed “spatial selectivity” cortical wirings which non-uniformly distributed domains manner. dynamics learning exhibit type-dependent “temporal selectivity”: corticocortical appear only transiently during phase, learning-induced new thalamocortical persist, indicating distinct circuits may supervise learning-specific ephemeral synapse memory-specific immortal formation. configuration temporal reconfiguration govern diverse functions

Language: Английский

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