iScience, Journal Year: 2024, Volume and Issue: 27(10), P. 110997 - 110997
Published: Sept. 20, 2024
Language: Английский
Stem Cell Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102387 - 102387
Published: Jan. 1, 2025
The mechanisms that determine distinct embryonic pallial identities remain elusive. central role of Wnt signaling in directing dorsal telencephalic progenitors to the isocortex or hippocampus has been elucidated. Here, we show timely inhibition MAPK/ERK and BMP neuralized mouse stem cells (ESCs) specifies a cell identity characteristic allocortex. Comparison global gene expression profiles neural generated by (MiBi cells) with those from early postnatal encephalic regions reveals MiBi cells, isocortical hippocampal cells. display unique pattern connectivity, share molecular electrophysiological features entorhinal cortex. Our results suggest changes can specify fates are maintained specific neuronal lineages independent subsequent morphogenetic interactions their functional connectivity.
Language: Английский
Citations
2
Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(8), P. 535 - 552
Published: May 23, 2024
Language: Английский
Citations
16
Current Biology, Journal Year: 2023, Volume and Issue: 33(20), P. 4353 - 4366.e5
Published: Sept. 19, 2023
The interplay between olfaction and higher cognitive processing has been documented in the adult brain; however, its development is poorly understood. In mice, shortly after birth, endogenous stimulus-evoked activity olfactory bulb (OB) boosts oscillatory entrainment of downstream lateral entorhinal cortex (LEC) hippocampus (HP). However, it unclear whether early OB a long-lasting impact on entorhinal-hippocampal function processing. Here, we chemogenetically silenced synaptic outputs mitral/tufted cells, main projection neurons OB, during postnatal days 8-10. transient manipulation leads to reduction coupling weaker responsiveness stimuli within developing circuits accompanied by dendritic sparsification LEC pyramidal neurons. Moreover, silencing reduces performance behavioral tests involving later life. Thus, neonatal critical for functional LEC-HP maturation abilities.
Language: Английский
Citations
18
Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(26), P. e1012232024 - e1012232024
Published: May 20, 2024
The third trimester is a critical period for the development of functional networks that support lifelong neurocognitive performance, yet emergence neuronal coupling in these poorly understood. Here, we used longitudinal high-density electroencephalographic recordings from preterm infants during 33 to 45 weeks conceptional age (CA) characterize early spatiotemporal patterns local cortical function and intrinsic modes [ICMs; phase–phase (PPCs), amplitude–amplitude (AACs), phase–amplitude correlations (PACs)]. Absolute power showed robust increase with CA across full frequency spectrum, while PACs sleep state-specific, biphasic peaked few before normal birth. AACs distant decreased globally at nearly all frequencies. In contrast, PPCs frequency- region-selective development, an strength between frontal, central, occipital regions low-delta alpha frequencies together wider-spread decrease other Our findings present spectrally spatially differential distinct ICMs neonatal provide their developmental templates future basic clinical research.
Language: Английский
Citations
5
Neurobiology of Learning and Memory, Journal Year: 2025, Volume and Issue: unknown, P. 108037 - 108037
Published: March 1, 2025
Memory retrieval involves coordinated activity across multiple brain regions. Yet how the organization of memory networks evolves throughout development remains poorly understood. In this study, we compared whole-brain functional that are active during contextual fear recall in infant, juvenile, and adult mice. Our analyses revealed long-term change significantly postnatal development. Infant dense heterogeneous, whereas sparse have a small-world topology. While hippocampal subregions were highly connected nodes at all ages, cortex gained many connections Different matured different rates, but their developmental timing fell into three major categories: stepwise between two linear or inverted-U, with elevated connectivity juveniles. work highlights subset regions likely maintain important roles encoding, undergoes significant reorganization Together, these results provide blueprint for studying correlated cellular key areas distinctly regulates storage
Language: Английский
Citations
0
Neuron, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
Neuron, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17
Published: July 13, 2023
We explored the potential for cFOS expression as a marker of functional development “resting-state” waking activity in extended network hippocampus and entorhinal cortex. examined sleeping awake mice at (P)ostnatal days 5, 9, 13, 17 well adulthood. find that is state-dependent even 5 old, with reliable staining occurring only mice. Even during waking, was rare weak P5. The septal nuclei, cortex layer (L)2, anterodorsal thalamus were exceptional they had robust P5 similar to or greater than Significant also observed dentate gyrus, L6, postsubiculum L4-6, ventral subiculum, supramammillary nucleus, posterior hypothalamic nucleus. these regions grew stronger age, new added progressively P9 P13 by which point overall pattern many qualitatively adult. Six regions—CA1, dorsal L2-3, reuniens perirhinal postrhinal cortices—were very late developing, mostly achieving adult levels after P17. Our findings support number developmental principles. First, early spontaneous patterns induced muscle twitches sleep do not induce hippocampal network. Second, follows progressive activation along trisynaptic circuit, rather birth date cellular maturation. Third, we reveal components egocentric head-direction theta-rhythm circuits earliest active forebrain. results suggest may provide sensitive biomarker formation development, particularly regard attainment normal state synchronizing rhythms such theta gamma.
Language: Английский
Citations
8
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2021, Volume and Issue: unknown
Published: Oct. 1, 2021
Abstract The prefrontal – hippocampal entorhinal system is perhaps the most widely-studied circuit in cognitive and systems neuroscience, due to its role supporting functions such as working memory decision-making. Disrupted communication within this a key feature of disorders schizophrenia dementia. Nucleus reuniens (NRe) midline thalamic nucleus that sits at nexus circuit, linking these regions together. As there are no direct projections from cortex hippocampus, accepted model NRe mediates drive activity, although connections poorly defined cellular synaptic level. Using ex vivo optogenetics electrophysiology, alongside monosynaptic circuit-tracing, we sought test mechanisms through which could activity. Unexpectedly, found evidence pyramidal cells CA1 receive input NRe, with hippocampus proper appearing selective for GABAergic interneurons. In other targeted by prosubiculum subiculum received inputs were least an order magnitude weaker than those or cortices. We conclude that, contrary widely-held assumptions field, not major target reuniens.
Language: Английский
Citations
17
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(10), P. 8721 - 8721
Published: May 13, 2023
The developing entorhinal–hippocampal system is embedded within a large-scale bottom-up network, where spontaneous myoclonic movements, presumably via somatosensory feedback, trigger hippocampal early sharp waves (eSPWs). hypothesis, that feedback links movements with eSPWs, implies direct stimulation should also be capable of evoking eSPWs. In this study, we examined responses to electrical the periphery in urethane-anesthetized, immobilized neonatal rat pups using silicone probe recordings. We found ~33% trials evoked local field potential (LFP) and multiple unit activity (MUA) identical somatosensory-evoked eSPWs were delayed from stimulus, on average, by 188 ms. Both (i) had similar amplitude ~0.5 mV half-duration ~40 ms, (ii) current-source density (CSD) profiles, current sinks CA1 strata radiatum, lacunosum-moleculare DG molecular layer (iii) associated MUA increase DG. Our results indicate can triggered stimulations support hypothesis sensory involved association rats.
Language: Английский
Citations
6