A physiological cause to empathy deficits in a mouse model of FTD DOI Creative Commons
Zhen Yan

Neuron, Journal Year: 2023, Volume and Issue: 111(6), P. 757 - 758

Published: March 1, 2023

Language: Английский

Cortical regulation of helping behaviour towards others in pain DOI
Mingmin Zhang, Ye Wu,

Mengping Jiang

et al.

Nature, Journal Year: 2024, Volume and Issue: 626(7997), P. 136 - 144

Published: Jan. 24, 2024

Language: Английский

Citations

31

The neural basis of affective empathy: what is known from rodents DOI

Sicong Peng,

Moyi Li,

Xiuqi Yang

et al.

Neuropharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 110347 - 110347

Published: Feb. 1, 2025

Language: Английский

Citations

1

Neural control of sex differences in affiliative and prosocial behaviors DOI Creative Commons

Sanja Mikulovic,

Constanze Lenschow

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106039 - 106039

Published: Feb. 1, 2025

Social interactions are vital for various taxa and species. Prosocial affiliative dynamics within a group between individuals not only pleasurable rewarding, but also appear to actively contribute well-being, cognitive performance, disease prevention. Moreover, disturbances in acting or being prosocial can represent major burden an individual their affective partners. These disruptions evident across spectrum of neuropsychiatric conditions, including depression autism disorders. Importantly, interactive patterns behavior vary with sex. The fact that genders differentially affected by disorders associated social impairment underscores the high importance this research uncovering underlying neural correlates mechanisms. This review focuses on elucidating sex-related differences behaviors potential association sexually different correlates. Specifically, we aim shed light complex interplay sex, behavior, neurobiology interaction patterns.

Language: Английский

Citations

1

Prosocial behaviors in rodents DOI Creative Commons
Michael Joe Munyua Gachomba, Joan Esteve-Agraz, Cristina Márquez

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 163, P. 105776 - 105776

Published: June 21, 2024

Prosocial behaviors (i.e., actions that benefit others) are central for social interactions in humans and other animals, by fostering bonding cohesion. To study prosociality rodents, scientists have developed behavioral paradigms where animals can display conspecifics distress or need. These provided insights into the role of transfer emotional states expression prosociality, increased knowledge its neural bases. However, levels variable: not all tested prosocial. Such variation has been linked to differences animals' ability process another's state as well contextual factors. Moreover, evidence suggests prosocial involve orchestrated activity multiple brain regions neuromodulators. This review aims synthesize findings across both at level behavior mechanisms. Growing confirms these processes be studied intense research past years is rapidly advancing our knowledge. We discuss a strong bias field towards negative valence contexts (e.g., pain, fear, stress), which should taken an opportunity open new venues future research.

Language: Английский

Citations

7

The effect of psilocybin on empathy and prosocial behavior: a proposed mechanism for enduring antidepressant effects DOI Creative Commons

Kush Bhatt,

Cory R. Weissman

npj Mental Health Research, Journal Year: 2024, Volume and Issue: 3(1)

Published: Feb. 20, 2024

Abstract Psilocybin is a serotonergic psychedelic shown to have enduring antidepressant effects. Currently, the mechanism for its effects not well understood. Empathy and prosocial behavior may be important understanding therapeutic benefit of psilocybin. In this article we review effect psilocybin on empathy behavior. Moreover, propose that induce positive feedback loop involving which helps explain observed,

Language: Английский

Citations

6

Neural mechanisms of comforting: Prosocial touch and stress buffering DOI Creative Commons
Kayla Y. Lim, Weizhe Hong

Hormones and Behavior, Journal Year: 2023, Volume and Issue: 153, P. 105391 - 105391

Published: June 8, 2023

Comforting is a crucial form of prosocial behavior that important for maintaining social unity and improving the physical emotional well-being species. It often expressed through affiliative touch toward someone in distress, providing relief their distressed state. In face increasing global these actions are paramount to continued improvement individual welfare collective good. Understanding neural mechanisms responsible promoting focused on benefitting others particularly timely. Here, we review comforting behavior, emphasizing synthesizing recent studies carried out using rodent models. We discuss its underlying behavioral expression motivations, then explore both neurobiology helper animal stress following recipient as part feedback loop interaction.

Language: Английский

Citations

16

Medial prefrontal cortex circuitry and social behaviour in autism DOI

Diego H. Mediane,

Shinjini Basu, Emma Cahill

et al.

Neuropharmacology, Journal Year: 2024, Volume and Issue: 260, P. 110101 - 110101

Published: Aug. 14, 2024

Language: Английский

Citations

5

Prosocial Helping Behavior: Conceptual Issues and Neural Mechanisms DOI
Nicole Rigney, Weizhe Hong

Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0

The Effect of Repetitive Transcranial Magnetic Stimulation of the Dorsolateral Prefrontal Cortex on the Amyotrophic Lateral Sclerosis Patients With Cognitive Impairment: A Double‐Blinded, Randomized, and Sham Control Trial DOI Creative Commons
Wensi Zheng, Xiaojie Zhang,

Jingjiong Chen

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(3)

Published: March 1, 2025

ABSTRACT Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. A large number of ALS patients have cognitive impairment. In this double‐blinded, randomized, and sham‐controlled study, we aimed to investigate the effect repetitive transcranial magnetic stimulation (rTMS) on with Methods total 90 impairment were recruited from two cohorts; 80 participants randomly assigned in 1:1 ratio receive 10 Hz rTMS or sham treatment bilateral dorsolateral prefrontal cortices (DLPFC) for 4 consecutive weeks. The assessed by ECAS ALSFRS‐R scales. Zarit care burden scale was administered caregivers patients. primary outcome measured rate decline score between pretreatment, 6 months post‐treatment, 12 post‐treatment. Secondary outcomes included group difference slope score, neurofilament light chain plasma levels. Results intention‐to‐treat population significantly changed 79.74 ± 6.39 81.98 6.51 79.22 6.50 intervention at 6‐month 12‐month follow‐ups, respectively ( p = 0.031, 0.042). also decreased 57.65 3.42 52.24 3.34 56.42 3.41 3‐month post‐treatment time points, 0.003, 0.014). No significant differences observed groups other secondary endpoints. However, there trend decreasing NF‐L level rates over first months' follow‐up. Conclusions could yield short‐term positive effects subgroup alleviate caregivers' burden. improvement severity biomarkers.

Language: Английский

Citations

0

Understanding Others’ Distress Through Past Experiences: The Role of Memory Engram Cells in Observational Fear DOI
Takashi Kitamura,

Kritika Ramesh,

Joseph I. Terranova

et al.

Advances in neurobiology, Journal Year: 2024, Volume and Issue: unknown, P. 215 - 234

Published: Jan. 1, 2024

Language: Английский

Citations

1