Organization of an ascending circuit that conveys flight motor state in Drosophila

Current Biology, Journal Year: 2024, Volume and Issue: 34(5), P. 1059 - 1075.e5

Published: Feb. 22, 2024

Language: Английский

---

Miniature linear and split-belt treadmills reveal mechanisms of adaptive motor control in walking Drosophila

Current Biology, Journal Year: 2024, Volume and Issue: 34(19), P. 4368 - 4381.e5

Published: Aug. 30, 2024

Language: Английский

---

Presynaptic inhibition selectively suppresses leg proprioception in behavingDrosophila

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 23, 2023

Controlling arms and legs requires feedback from proprioceptive sensory neurons that detect joint position movement. Proprioceptive must be tuned for different behavioral contexts, but the underlying circuit mechanisms remain poorly understood. Using calcium imaging in behaving

Language: Английский

---

Divergent neural circuits for proprioceptive and exteroceptive sensing of theDrosophilaleg

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 28, 2024

Abstract Somatosensory neurons provide the nervous system with information about mechanical forces originating inside and outside body. Here, we use connectomics from electron microscopy to reconstruct analyze neural circuits downstream of largest somatosensory organ in Drosophila leg, femoral chordotonal (FeCO). The FeCO has been proposed support both proprioceptive sensing fly’s femur-tibia joint exteroceptive substrate vibrations, but it was unknown which sensory central contribute each these functions. We found that different subtypes feed into distinct pathways. Position- movement-encoding connect local leg motor control ventral nerve cord (VNC), indicating a function. In contrast, signals vibration-encoding are integrated across legs transmitted mechanosensory regions brain, an Overall, our analyses reveal structure specialized for processing fly leg. These findings consistent growing body work invertebrate vertebrate species demonstrating existence limb pathways external vibrations.

Language: Английский

---

Structure of the Femoral Chordotonal Organ in the Oleander Hawkmoth, Daphnis nerii

The Journal of Comparative Neurology, Journal Year: 2025, Volume and Issue: 533(2)

Published: Feb. 1, 2025

ABSTRACT Insect legs serve as crucial organs for locomotion and also act sensory probes into the environment. They are involved in several complex movements including walking, jumping, prey capture, manipulation of objects, self‐grooming. These behaviors require continuous modulation motor output through mechanosensory feedback, which is provided by numerous mechanosensors located on cuticle within soft tissue. A key organ insect leg, femoral chordotonal (FeCO), detects femoro‐tibial joint. This multifunctional senses both self‐generated (proprioception) external stimuli (exteroception). Movements tibia alter length FeCO, activates embedded neurons. Due to mechanical nature these stimuli, structure material properties FeCO their function, alongside encoding Here, a first step toward understanding how its modulates we characterized morphology anatomy hawkmoth Daphnis nerii . Using combination computed micro‐tomography, neuronal dye fills, confocal microscopy, describe location, composition, central projections proximal half femur composed ventral (vFeCO) dorsal scoloparia (dFeCO), vary vastly sizes number neurons they house. Moreover, characteristic accessory structures organs, scolopales, significantly differ when compared between two scoloparia. project nervous system terminate respective hemiganglia. morphological data, propose model can help us understand relating physiological function.

Language: Английский

---

Interactions of morphology and leg-driven locomotor behaviour in insects

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 191 - 225

Published: Jan. 1, 2025

Language: Английский

---

Mechanosensory Control of Locomotion in Animals and Robots: Moving Forward

Integrative and Comparative Biology, Journal Year: 2023, Volume and Issue: 63(2), P. 450 - 463

Published: June 5, 2023

While animals swim, crawl, walk, and fly with apparent ease, building robots capable of robust locomotion remains a significant challenge. In this review, we draw attention to mechanosensation-the sensing mechanical forces generated within outside the body-as key sense that enables in animals. We discuss differences between mechanosensation current respect (1) encoding properties distribution mechanosensors (2) integration regulation mechanosensory feedback. argue robotics would benefit greatly from detailed understanding these aspects To end, highlight promising experimental engineering approaches study mechanosensation, emphasizing mutual benefits for biologists engineers emerge moving forward together.

Language: Английский

---

Miniature linear and split-belt treadmills reveal mechanisms of adaptive motor control in walkingDrosophila

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 24, 2024

Abstract To navigate complex environments, walking animals must detect and overcome unexpected perturbations. One technical challenge when investigating adaptive locomotion is measuring behavioral responses to precise perturbations during naturalistic walking; another that manipulating neural activity in sensorimotor circuits often reduces spontaneous locomotion. these obstacles, we introduce miniature treadmill systems for coercing tracking 3D kinematics of Drosophila . By systematically comparing three experimental setups, show flies compelled walk on the linear have similar stepping freely flies, while tethered are subtly different. Genetically silencing mechanosensory neurons alters step across all speeds, inter-leg coordination remains intact. We also found can maintain a forward heading split-belt by adapting distance their middle legs. Overall, new insights demonstrate utility treadmills studying insect

Language: Английский

---

Bio-inspired spreadable multi-signal self-sensing covering composite material for intelligent devices

Composites Communications, Journal Year: 2024, Volume and Issue: unknown, P. 102085 - 102085

Published: Sept. 1, 2024

---

Distinct molecular and functional properties of human induced-proprioceptor and low-threshold mechanoreceptor neurons

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 12, 2024

Abstract Sensing mechanical stimuli is crucial for the function of internal and external tissues, such as skin muscles. Much our understanding mechanosensory physiology relies on rodent studies, which may not directly translate to humans. To address knowledge gap in human mechanosensation, we developed distinct populations neuronal subtypes from pluripotent stem cells (hPSC). By inducing co-expression NGN2/RUNX3 or NGN2/SHOX2 hPSC-derived migrating neural crest directed their specification proprioceptor low-threshold mechanoreceptor subtypes, respectively. The induced neurons exhibited transcriptional profiles consistent with displayed functional responses stimuli, stretch submicrometer probe indentation soma. Notably, each subtype unique thresholds desensitization properties akin proprioceptors mechanoreceptors both fired action potentials response minute predominantly relying PIEZO2 function. Collectively, this study provides a foundational model exploring biology.

Language: Английский

---