Personalized cue-reactive delta-theta oscillations guide deep brain stimulation for opioid use disorder DOI Open Access
Liming Qiu, Young‐Hoon Nho,

Robert Seilheimer

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Abstract / Summary Substance use disorders (SUDs) are a significant public health concern, with over 30% failing available treatment. Severe SUD is characterized by drug-cue reactivity that predicts treatment-failure. We leveraged this pathophysiological feature to personalize deep brain stimulation (DBS) of the nucleus accumbens region (NAc) in an patient. While DBS lead was externalized for clinical purposes, we administered personalized drug cue-reactivity task while recording NAc electrophysiology. identified cue-evoked signal ventral associated intensification opioid-related cravings, which attenuated therapeutic delivered same area. then programmed engage subregion within account biomarker location, heralding potential strategies optimize SUD.

Language: Английский

Personalized cue-reactive delta-theta oscillations guide deep brain stimulation for opioid use disorder DOI Open Access
Liming Qiu, Young‐Hoon Nho,

Robert Seilheimer

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Abstract / Summary Substance use disorders (SUDs) are a significant public health concern, with over 30% failing available treatment. Severe SUD is characterized by drug-cue reactivity that predicts treatment-failure. We leveraged this pathophysiological feature to personalize deep brain stimulation (DBS) of the nucleus accumbens region (NAc) in an patient. While DBS lead was externalized for clinical purposes, we administered personalized drug cue-reactivity task while recording NAc electrophysiology. identified cue-evoked signal ventral associated intensification opioid-related cravings, which attenuated therapeutic delivered same area. then programmed engage subregion within account biomarker location, heralding potential strategies optimize SUD.

Language: Английский

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