Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 14, 2024
Abstract
Our
naturalistic
experiences
are
organized
into
memories
through
multiple
processes,
including
novelty
encoding,
memory
formation,
and
retrieval.
However,
the
neural
mechanisms
coordinating
these
processes
remain
elusive.
Using
fMRI
data
acquired
during
movie
viewing
subsequent
narrative
recall,
we
examined
hippocampal
subspaces
associated
with
distinct
characterized
their
relationships.
We
quantified
in
character
co-occurrences
valence
of
relationships
estimated
event
memorability.
Within
hippocampus,
encoding
each
type
exhibited
partial
overlap,
overlapping
aligned
subspace
involved
Notably,
following
boundaries,
states
within
inversely
along
a
shared
coding
axis,
predicting
recall
performance.
This
novelty-memorability
alignment
was
selectively
observed
but
not
findings
offer
novel
insights
how
hippocampus
dynamically
coordinates
computations
underlying
retrieval
at
population
level
to
transform
ongoing
enduring
memories.
Proceedings of the National Academy of Sciences,
Journal Year:
2025,
Volume and Issue:
122(3)
Published: Jan. 14, 2025
The
hippocampus
possesses
anatomical
differences
along
its
long
axis.
Here,
we
explored
the
functional
specialization
of
human
hippocampal
axis
using
network-anchored
precision
MRI
in
two
independent
datasets
(N
=
11
and
N
9)
paired
with
behavioral
analysis
266
238).
Functional
connectivity
analyses
demonstrated
that
anterior
was
preferentially
correlated
a
cerebral
network
associated
remembering,
while
posterior
selectively
contained
region
distinct
salience.
Seed
regions
placed
within
recapitulated
networks.
characterization
task
data
identified
replicated
double
dissociation.
sensitive
to
remembering
imagining
future,
specifically
tracking
process
scene
construction,
displayed
transient
responses
targets
an
oddball
detection
transitions
between
blocks.
These
findings
suggest
unexpected
differential
reflecting
properties
partner
Brain and Neuroscience Advances,
Journal Year:
2025,
Volume and Issue:
9
Published: Jan. 1, 2025
Apolipoprotein
E
ε4
is
a
major
genetic
risk
factor
for
Alzheimer’s
disease,
and
some
apolipoprotein
carriers
show
disease–related
neuropathology
many
years
before
cognitive
changes
are
apparent.
Therefore,
studying
healthy
genotyped
individuals
offers
an
opportunity
to
investigate
the
earliest
in
brain
measures
that
may
signal
presence
of
disease-related
processes.
For
example,
subtle
functional
magnetic
resonance
imaging
connectivity,
particularly
within
default
mode
network,
have
been
described
when
comparing
ε3
carriers.
Similarly,
very
mild
impairments
episodic
memory
also
documented
Here,
we
use
naturalistic
activity
(movie
watching),
marker
encoding
(transient
connectivity
around
so-called
‘event
boundaries’),
potential
phenotype
differences
associated
with
genotype
large
sample
adults.
Using
Bayes
analyses,
found
strong
evidence
against
existence
allelic
status.
did
not
find
E-associated
ran
exploratory
analyses
examining:
system
segregation
across
whole
brain,
network.
We
conclude
has
little
or
no
effect
on
how
ongoing
experiences
processed
The
observed
studies
reflect
early
effects
pathology
Neuroscience & Biobehavioral Reviews,
Journal Year:
2024,
Volume and Issue:
163, P. 105737 - 105737
Published: May 23, 2024
Throughout
the
educational
system,
students
experiencing
active
learning
pedagogy
perform
better
and
fail
less
than
those
taught
through
direct
instruction.
Can
this
be
ascribed
to
differences
in
from
a
neuroscientific
perspective?
This
review
examines
mechanistic,
evidence
that
might
explain
cognitive
engagement
contributing
outcomes
between
these
instructional
approaches.
In
classrooms,
instruction
comprehensively
describes
academic
content,
while
provides
structured
opportunities
for
learners
explore,
apply,
manipulate
content.
Synaptic
plasticity
its
modulation
by
arousal
or
novelty
are
central
all
both
As
form
of
social
learning,
relies
upon
working
memory.
The
reinforcement
circuit,
associated
agency,
curiosity,
peer-to-peer
interactions
combine
enhance
motivation,
improve
retention,
build
higher-order-thinking
skills
environments.
When
memory
becomes
overwhelmed,
additionally
engaging
circuit
improves
providing
an
explanation
benefits
learning.
analysis
mechanistic
examination
how
emerging
neuroscience
principles
inform
pedagogical
choices
at
levels.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 14, 2025
Our
naturalistic
experiences
are
organized
into
memories
through
multiple
processes,
including
novelty
encoding,
memory
formation,
and
retrieval.
However,
the
neural
mechanisms
coordinating
these
processes
remain
elusive.
Using
fMRI
data
acquired
during
movie
viewing
subsequent
narrative
recall,
we
examine
hippocampal
subspaces
associated
with
distinct
characterized
their
relationships.
We
quantify
in
character
co-occurrences
valence
of
relationships
estimate
event
memorability.
Within
hippocampus,
encoding
each
type
exhibit
partial
overlap,
overlapping
align
subspace
involved
Notably,
following
boundaries,
states
within
inversely
along
a
shared
coding
axis,
predicting
recall
performance.
This
novelty-memorability
alignment
is
selectively
observed
but
not
Finally,
identified
functional
reflect
intrinsic
organization
hippocampus.
findings
offer
insights
how
hippocampus
dynamically
coordinates
representations
underlying
retrieval
at
population
level
to
transform
ongoing
enduring
memories.
In
this
study,
authors
show
that
aligns
formation
retrieval,
components
process
its
organisation.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 13, 2025
Prior
behavioral
work
showed
that
event
structure
plays
a
key
role
in
our
ability
to
mentally
search
through
memories
of
continuous
naturalistic
experience.
We
hypothesized
that,
neurally,
this
mem-
ory
process
involves
division
labor
between
slowly
un-
furling
neocortical
states
representing
knowledge
and
fast
hippocampal-neocortical
communication
supports
retrieval
new
information
at
transitions
events.
To
test
this,
we
tracked
slow
neural
state-patterns
sample
ten
patients
under-
going
intracranial
electroencephalography
as
they
viewed
movie
then
searched
their
structured
in-
terview.
As
answered
questions
("after
X,
when
does
Y
happen
next?"),
from
movie-viewing
were
reinstated
neocortex;
during
memory-search,
unfurled
forward
di-
rection.
Moments
state-transition
marked
by
low-frequency
power
decreases
cortex
preceded
hip-
pocampus
correlated
with
reinstatement.
Connectivity-analysis
revealed
information-flow
hippocampus
underpinning
state-transitions.
Together,
these
results
support
hypothesis
hippocampal
processes
bridge
memory
search.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 23, 2024
The
hippocampus
has
a
unique
microarchitecture,
is
situated
at
the
nexus
of
multiple
macroscale
functional
networks,
contributes
to
numerous
cognitive
as
well
affective
processes,
and
highly
susceptible
brain
pathology
across
common
disorders.
These
features
make
model
understand
how
structure
covaries
with
function,
in
both
health
disease.
Here,
we
introduce
HippoMaps,
an
open
access
toolbox
online
data
warehouse
for
mapping
contextualization
hippocampal
human
(http://hippomaps.readthedocs.io).
HippoMaps
capitalizes
on
novel
unfolding
approach
shape
intrinsic
registration
capabilities
allow
cross-subject
cross-modal
aggregation.
We
initialize
this
repository
spanning
3D
post-mortem
histology,
ex-vivo
9.4
Tesla
MRI,
in-vivo
structural
MRI
resting-state
(rsfMRI)
obtained
3
7
Tesla,
together
intracranial
encephalography
(iEEG)
recordings
epilepsy
patients.
also
contains
validated
tools
spatial
map
association
analysis
that
correct
autocorrelation.
All
code
are
compliant
community
standards,
comprehensive
tutorials
facilitate
broad
adoption.
Applications
work
span
methodologies
modalities,
scales,
clinical
basic
research
contexts,
encourage
feedback
contributions
spirit
iterative
scientific
resource
development.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 25, 2024
Abstract
The
hippocampus
has
a
unique
microarchitecture,
is
situated
at
the
nexus
of
multiple
macroscale
functional
networks,
contributes
to
numerous
cognitive
as
well
affective
processes,
and
highly
susceptible
brain
pathology
across
common
disorders.
These
features
make
model
understand
how
structure
covaries
with
function,
in
both
health
disease.
Here,
we
introduce
HippoMaps,
an
open
access
toolbox
online
data
warehouse
for
mapping
contextualization
hippocampal
human
(http://hippomaps.readthedocs.io).
HippoMaps
capitalizes
on
novel
unfolding
approach
shape
intrinsic
registration
capabilities
allow
cross-subject
cross-modal
aggregation.
We
initialize
this
repository
spanning
3D
post-mortem
histology,
ex-vivo
9.4
Tesla
MRI,
in-vivo
structural
MRI
resting-state
(rsfMRI)
obtained
3
7
Tesla,
together
intracranial
encephalography
(iEEG)
recordings
epilepsy
patients.
also
contains
validated
tools
spatial
map
association
analysis
that
correct
autocorrelation.
All
code
are
compliant
community
standards,
comprehensive
tutorials
facilitate
broad
adoption.
Applications
work
span
methodologies
modalities,
scales,
clinical
basic
research
contexts,
encourage
feedback
contributions
spirit
iterative
scientific
resource
development.
