Subregion‐specific thalamocortical functional connectivity, executive function, and social behavior in children with autism spectrum disorders DOI
Jasmine Chuah,

Aisleen Manahan,

Shi Yu Chan

et al.

Autism Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Abstract The thalamus has extensive cortical connections and is an integrative hub for cognitive functions governing social behavior. This study examined (1) associations between thalamocortical resting‐state functional connectivity (RSFC) behavior in children (2) how various executive function (EF) subdomains mediate the association RSFC Children from autism brain imaging data exchange (ABIDE) initiative with neuroimaging, behavioral, demographic were included our (age < 14, ASD; n = 207, typically developing; 259). Thalamocortical was communication interaction (SCI) scores (SRS; responsiveness scale) using Spearman's rank‐order correlation, first ASD then developing children. followed by a more granular analysis at thalamic subregion level. We mediating roles of eight EF ( 139). Right thalamus‐default mode network (DMN) significantly associated SCI ρ 0.23, p FDR 0.012), primarily driven medial 0.22, 0.013), ventral 0.17, 0.036), intralaminar 0.036) subregions. Cognitive flexibility (ACME 0.13, unc 0.016) emotional control 0.08, 0.020) mediated right thalamus‐DMN scores. provided novel insights into level, providing higher levels precision brain‐behavior mapping. emotion regulation highlighted as potential targets to ameliorate downstream effects altered improve outcomes

Language: Английский

Subregion‐specific thalamocortical functional connectivity, executive function, and social behavior in children with autism spectrum disorders DOI
Jasmine Chuah,

Aisleen Manahan,

Shi Yu Chan

et al.

Autism Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Abstract The thalamus has extensive cortical connections and is an integrative hub for cognitive functions governing social behavior. This study examined (1) associations between thalamocortical resting‐state functional connectivity (RSFC) behavior in children (2) how various executive function (EF) subdomains mediate the association RSFC Children from autism brain imaging data exchange (ABIDE) initiative with neuroimaging, behavioral, demographic were included our (age < 14, ASD; n = 207, typically developing; 259). Thalamocortical was communication interaction (SCI) scores (SRS; responsiveness scale) using Spearman's rank‐order correlation, first ASD then developing children. followed by a more granular analysis at thalamic subregion level. We mediating roles of eight EF ( 139). Right thalamus‐default mode network (DMN) significantly associated SCI ρ 0.23, p FDR 0.012), primarily driven medial 0.22, 0.013), ventral 0.17, 0.036), intralaminar 0.036) subregions. Cognitive flexibility (ACME 0.13, unc 0.016) emotional control 0.08, 0.020) mediated right thalamus‐DMN scores. provided novel insights into level, providing higher levels precision brain‐behavior mapping. emotion regulation highlighted as potential targets to ameliorate downstream effects altered improve outcomes

Language: Английский

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