Effect of Cytoskeletal Linker Protein GAS2L1 on Oligodendrocyte and Myelin Development

Glia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Oligodendrocytes (OLs), the myelin-forming cells of central nervous system (CNS), develop from OL precursor (OPCs) through a complex process involving significant morphological changes that are critically dependent on dynamic interactions between cytoskeletal networks. Growth arrest-specific 2-like protein 1 (GAS2L1) is linker mediates cross-talk actin filaments and microtubules. However, its role in myelin development remains unknown. Here, we report GAS2L1 expressed both OPCs mature OLs, overexpression or knockdown Gas2l1 cultured vitro impaired enhanced their differentiation, respectively, while inhibited proliferation. We generated

Language: Английский

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Unraveling the Roles of UBE3A in Neurodevelopment and Neurodegeneration

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2304 - 2304

Published: March 5, 2025

The ubiquitin-protein ligase E3A (UBE3A, aka E6-AP), an E3 belonging to the HECT family, plays crucial roles in stability of various proteins through proteasomal degradation system. Abnormal UBE3A activity is essential for initiation and progression several cancers. A gain function overdosage maternal associated with increased risk autism spectrum disorders. Conversely, a loss due mutations, deletions, paternal duplications, or imprinting defects neurons leads Angelman syndrome. Emerging evidence suggests that abnormal may also contribute development brain disorders, including schizophrenia, Huntington's disease, Parkinson's Alzheimer's making protein significant interest. However, research on UBE3A's functions has primarily focused mature neuronal cells, while being obscured glia. This review outlines expression glial cells based published studies, highlights newly identified patterns UBE3A, such as its secretion, emphasizes involvement neurodegenerative diseases. Furthermore, we summarize propose model bi-directional interactions between glia mediated by underlies functions. Insights gained from this could provide new avenues therapeutic interventions targeting

Language: Английский

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PD-L1/PD-1 checkpoint pathway regulates astrocyte morphogenesis and myelination during brain development

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Language: Английский

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Glial cell interactions in neonatal hypoxic-ischemic injury

Glial health research., Journal Year: 2025, Volume and Issue: unknown, P. 100006 - 100006

Published: April 1, 2025

Language: Английский

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Neural Responses to Hypoxic Injury in a Vascularized Cerebral Organoid Model

Neuroscience Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Language: Английский

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Research Progress on Pericytes in Central Nervous System Diseases

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(04), P. 3357 - 3368

Published: Jan. 1, 2025

Language: Английский

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Deciphering the role of circular RNAs in cancer progression under hypoxic conditions

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(6)

Published: May 2, 2025

Language: Английский

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Pericytes: Unsung heroes in myelin repair after neonatal brain hypoxia

Neuron, Journal Year: 2024, Volume and Issue: 112(13), P. 2081 - 2083

Published: July 1, 2024

Language: Английский

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Oxygen-induced stress reveals context-specific gene regulatory effects in human brain organoids

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

The interaction between genetic variants and environmental stressors is key to understanding the mechanisms underlying neurological diseases. In this study, we used human brain organoids explore how varying oxygen levels expose context-dependent gene regulatory effects. By subjecting a genetically diverse panel of 21 hypoxic hyperoxic conditions, identified thousands changes that are undetectable under baseline with 1,745 trait-associated genes showing effects only in response stress. To capture more nuanced transcriptional patterns, employed topic modeling, which revealed context-specific regulation linked dynamic cellular processes responses, offering deeper modulated brain. These findings underscore importance genotype-environment interactions studies disorders provide new insights into hidden influenced by factors

Language: Английский

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The Hidden Hand in White Matter: Pericytes and the Puzzle of Demyelination

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(10), P. 2912 - 2923

Published: Sept. 19, 2024

Disruption of myelin, the fatty sheath-insulating nerve fibers in white matter, blocks or slows rapid transmission electrical signals along cells and contributes to several neurodegenerative diseases such as multiple sclerosis. Traditionally, research has focused on neuronal dysfunction primary factor, including autoimmunity, infections, inflammation, genetic disorders causing demyelination. However, recent insights emphasize critical role pericytes, non-neuronal that regulate blood flow maintain health vessels within matter. This Perspective explores principal mechanisms through which pericyte damage demyelination, impaired communication with neurons (neurovascular uncoupling), excessive formation scar tissue (fibrosis), infiltration detrimental substances from bloodstream. Understanding these pericyte-driven demyelination may lead creation new therapeutic strategies for tackling a range conditions.

Language: Английский

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