Processing reliant on granule cells is essential for motor learning but dispensable for many cerebellar-dependent behaviors DOI Open Access
Joon-Hyuk Lee, Chong Guo, Shuting Wu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Abstract Cerebellar dysfunction leads to motor, learning, emotional, and social deficits. It is assumed that these deficits arise from impaired processing of mossy fiber inputs activate granule cells (GCs) in turn excite Purkinje (PCs). However, high-frequency spontaneous PC firing might also influence behaviors. To clarify how the cerebellum regulates behaviors, we compared effects disrupting either GC signaling, which selectively perturbs cerebellar processing, or disrupts firing. We find both signaling are required for eyeblink conditioning vestibulo-ocular reflex (VOR) learning. impairs baseline VOR, anxiety, but abolishing does not. This establishes essential motor not many cerebellum-dependent suggests such behaviors could be rescued by elevating downstream targets, as shown previously

Language: Английский

Processing reliant on granule cells is essential for motor learning but dispensable for many cerebellar-dependent behaviors DOI Open Access
Joon-Hyuk Lee, Chong Guo, Shuting Wu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Abstract Cerebellar dysfunction leads to motor, learning, emotional, and social deficits. It is assumed that these deficits arise from impaired processing of mossy fiber inputs activate granule cells (GCs) in turn excite Purkinje (PCs). However, high-frequency spontaneous PC firing might also influence behaviors. To clarify how the cerebellum regulates behaviors, we compared effects disrupting either GC signaling, which selectively perturbs cerebellar processing, or disrupts firing. We find both signaling are required for eyeblink conditioning vestibulo-ocular reflex (VOR) learning. impairs baseline VOR, anxiety, but abolishing does not. This establishes essential motor not many cerebellum-dependent suggests such behaviors could be rescued by elevating downstream targets, as shown previously

Language: Английский

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