Role of the Thalamic Reticular Nucleus in Social Memory DOI
Xue Liu,

Jianing Zhu,

Junqiang Zheng

et al.

Neuroscience Bulletin, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 7, 2024

Language: Английский

Claims of necessity and sufficiency are not well suited for the study of complex systems DOI

G. Lindsay

The Transmitter, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
AAV-mediated peripheral single chain variable fragments administration to reduce cerebral tau in adult P301S transgenic mice: mono- vs combination therapy DOI Creative Commons

Sebica Katel,

Julia Cicalo,

Valeria Vasciaveo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Abstract Tau is a primary target for immunotherapy in Alzheimer’s disease. Recent studies have shown the potential of anti-tau fragment antibodies lowering pathological tau levels vitro and vivo . Here, we compared effects single-chain variable fragments (scFv) derived from well-characterized monoclonal PHF1 MC1. We used adeno-associated virus 1 (AAV1) to deliver scFvs skeletal muscle cells eight-week-old P301S transgenic mice. evaluated motor behavioral functions at 16 23 weeks age measured misfolded, soluble, oligomeric insoluble brain species. Monotherapy with scFv-MC1 improved more effectively than scFv-PHF1 or combination therapy. Brain glucose metabolism also benefited treatment. Surprisingly, combining targeting early (MC1) late (PHF1) modifications did not produce additive synergistic effects. These results confirm that intramuscular AAV1-mediated gene therapy holds promise as treatment Our findings suggest different epitopes may necessarily enhance efficacy if administered together prevention paradigm. Further research needed explore whether other antibodies’ combinations and/or administration schedules could improve alone. Graphical abstract/eTOC synopsis Katel colleagues show peripheral vectorized scFvMC1 (in monotherapy) reduces species mice efficiently scFv-PHF1. The authors observed increased scFv-MC1-treated

Language: Английский

Citations

0
Somatostatin-expressing interneurons of prefrontal cortex modulate social deficits in the Magel2 mouse model of autism DOI Creative Commons

Xiaona Wang,

Mengyuan Chen,

Daoqi Mei

et al.

Molecular Autism, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 11, 2025

Dysfunction in social interactions is a core symptom of autism spectrum disorder (ASD). Nevertheless, the neural mechanisms underlying deficits ASD are poorly understood. By integrating electrophysiological, vivo fiber photometry, viral-mediated tracing, optogenetic and pharmacological stimulation, we show reduced intrinsic excitability hypoactivity SOM interneurons medial prefrontal cortex (mPFC) Magel2-deficient mice, an established model, were required to defects. Chemogenetic inhibition mPFC SOM-containing resulted interaction wild-type Magel2 mice. These sociability can be rescued by activation mPFCSOM-LS inhibitory pathway Magel 2 knockout results demonstrate for action impairments, suggest targeting this mechanism that may prove therapeutically beneficial mitigating behavioral disturbances observed ASD.

Language: Английский

Citations

0
A molecularly defined mPFC-BLA circuit specifically regulates social novelty preference DOI Creative Commons
Y. Liu, Ying Wang, Guoguang Xie

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(17)

Published: April 23, 2025

Social novelty preference is an important aspect of social interaction for evaluating new threats and opportunities survival, but the underlying neuronal mechanism remains unclear. Here, we identify a molecularly defined medial prefrontal cortex (mPFC) excitatory neuron subtype, located in layer 5 expressing Il1rapl2 , which highly associated with deficit disorders genome-wide association studies might be responsible regulating preference. Using -Cre mouse line, show that chemogenetic activation mPFC -expressing neurons impairs little effect on sociability. In addition, fiber photometry recording indicates this subtype inhibited when mice interact novel not familiar mice. Furthermore, viral tracing terminal manipulation reveal basolateral amygdala (BLA)–projecting + mediate Thus, our study uncovers mPFC-BLA circuit specifically regulates preference, highlighting specific subtypes circuits could modulate distinct aspects behaviors.

Language: Английский

Citations

0
A small population of stress-responsive neurons in the hypothalamus-habenula circuit mediates development of depression-like behavior in mice DOI
Zhi-Wei Zheng,

Yiqin Liu,

Ruiqi Mu

et al.

Neuron, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

3
Integration of distinct cortical inputs to primary and higher order inhibitory cells of the thalamus DOI Creative Commons

Christian D. Puzzo,

Rosa I. Martinez-Garcia,

H Liu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 13, 2024

The neocortex controls its own sensory input in part through top-down inhibitory mechanisms. Descending corticothalamic projections drive GABAergic neurons of the thalamic reticular nucleus (TRN), which govern thalamocortical cell activity via inhibition. Neurons TRN are organized into primary and higher order (HO) subpopulations, with separate intrathalamic connections distinct genetic functional properties. Here, we investigated neocortical control over HO somatosensory TRN. Projections from layer 6 cortex evoked stronger more state-dependent than TRN, driven by robust synaptic inputs potent T-type calcium currents. However, received additional, physiologically distinct, motor 5 S1. Thus, a departure canonical focused innervation characteristic integrates broadly multiple systems, unique state-dependence, extending range mechanisms for control.

Language: Английский

Citations

1
Mapping the social memory network DOI

Maria Papatriantafyllou

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(7), P. 449 - 449

Published: May 15, 2024

Language: Английский

Citations

0
Thalamic cells and pathway for social memory processing and storage DOI
Wen‐Jun Gao

Neuron, Journal Year: 2024, Volume and Issue: 112(14), P. 2259 - 2261

Published: July 1, 2024

Language: Английский

Citations

0
Repeated postnatal sevoflurane exposure impairs social recognition in mice by disrupting GABAergic neuronal activity and development in hippocampus DOI
S.J. Wang, Zijie Li,

Xin Liu

et al.

British Journal of Anaesthesia, Journal Year: 2024, Volume and Issue: 133(4), P. 810 - 822

Published: Aug. 13, 2024

Language: Английский

Citations

0
Role of the Thalamic Reticular Nucleus in Social Memory DOI
Xue Liu,

Jianing Zhu,

Junqiang Zheng

et al.

Neuroscience Bulletin, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 7, 2024

Language: Английский

Citations

0