Analysis of a shark reveals ancient, Wnt-dependent, habenular asymmetries in vertebrates DOI Creative Commons
Maxence Lanoizelet, Léo Michel,

Ronan Lagadec

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 25, 2024

The mode of evolution left-right asymmetries in the vertebrate habenulae remains largely unknown. Using a transcriptomic approach, we show that cartilaginous fish, catshark Scyliorhinus canicula, exhibit marked asymmetries, both their medial and lateral components. Comparisons across vertebrates suggest those identified reflect an ancestral gnathostome trait, partially conserved lampreys, independently lost tetrapods neopterygians. Asymmetry formation involves distinct mechanisms habenulae. Medial are submitted to marked, asymmetric temporal regulation neurogenesis, undetectable counterparts. Conversely, asymmetry results from choices neuronal identity post-mitotic progenitors, dependent on repression Wnt signaling by Nodal left. Based comparisons with mouse zebrafish, propose habenular recurrent developmental logic vertebrates, which relies conserved, temporally regulated genetic programs sequentially shaping sides asymmetrically modified activity.

Language: Английский

Serotonin release in the habenula during emotional contagion promotes resilience DOI
Sarah Mondoloni, Patricia E. Molina, Salvatore Lecca

et al.

Science, Journal Year: 2024, Volume and Issue: 385(6713), P. 1081 - 1086

Published: Sept. 5, 2024

Negative emotional contagion-witnessing others in distress-affects an individual's responsivity. However, whether it shapes coping strategies when facing future threats remains unknown. We found that mice briefly observe a conspecific being harmed become resilient, withstanding behavioral despair after adverse experience. Photometric recordings during negative contagion revealed increased serotonin (5-HT) release the lateral habenula. Whereas 5-HT and reduced habenular burst firing, limiting synthesis prevented plasticity. Enhancing raphe-to-habenula was sufficient to recapitulate resilience. In contrast, reducing habenula made witnessing distress ineffective promote resilient phenotype adversity. These findings reveal supports vicarious emotions leads resilience by tuning definite patterns of neuronal activity.

Language: Английский

Citations

9
Glutamate-mediated antidepressant effects of Jieyu I Formula via modulation of PFCCaMKII-LHbCaMKII/GABA circuitry in lipopolysaccharide-induced depression model DOI

Jialong Zhong,

Huan Li,

Kerun Cao

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119414 - 119414

Published: Jan. 1, 2025

Language: Английский

Citations

0
Brain circadian clocks timing the 24h rhythms of behavior DOI Creative Commons
Jorge Mendoza

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: March 22, 2025

Language: Английский

Citations

0
Functional Adaptation in the Brain Habenulo–Mesencephalic Pathway During Cannabinoid Withdrawal DOI Creative Commons
Sonia Aroni, Claudia Sagheddu, Marco Pistis

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(21), P. 1809 - 1809

Published: Nov. 1, 2024

The mesolimbic reward system originating from dopamine neurons in the ventral tegmental area (VTA) of midbrain shows a profound reduction function during cannabinoid withdrawal. This condition may underlie aversive states that lead to compulsive drug seeking and relapse. lateral habenula (LHb) exerts negative control over VTA via GABA rostromedial nucleus (RMTg), representing potential convergence point for drug-induced opponent processes. We hypothesized LHb-RMTg pathway might be causally involved hypodopaminergic state To induce Δ

Language: Английский

Citations

1
Analysis of a shark reveals ancient, Wnt-dependent, habenular asymmetries in vertebrates DOI Creative Commons
Maxence Lanoizelet, Léo Michel,

Ronan Lagadec

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 25, 2024

The mode of evolution left-right asymmetries in the vertebrate habenulae remains largely unknown. Using a transcriptomic approach, we show that cartilaginous fish, catshark Scyliorhinus canicula, exhibit marked asymmetries, both their medial and lateral components. Comparisons across vertebrates suggest those identified reflect an ancestral gnathostome trait, partially conserved lampreys, independently lost tetrapods neopterygians. Asymmetry formation involves distinct mechanisms habenulae. Medial are submitted to marked, asymmetric temporal regulation neurogenesis, undetectable counterparts. Conversely, asymmetry results from choices neuronal identity post-mitotic progenitors, dependent on repression Wnt signaling by Nodal left. Based comparisons with mouse zebrafish, propose habenular recurrent developmental logic vertebrates, which relies conserved, temporally regulated genetic programs sequentially shaping sides asymmetrically modified activity.

Language: Английский

Citations

1