Syngap1 regulates the synaptic drive and membrane excitability of Parvalbumin-positive interneurons in mouse auditory cortex DOI Open Access
Ruggiero Francavilla,

Bidisha Chattopadhyaya,

Jorelle Linda Damo Kamda

et al.

Published: May 1, 2024

SYNGAP1 haploinsufficiency-related intellectual disability (SYNGAP1-ID) is characterized by moderate to severe ID, generalized epilepsy, autism spectrum disorder, sensory processing dysfunction and other behavioral abnormalities. While numerous studies have highlighted a role of Syngap1 in cortical excitatory neurons development; recent suggest that plays GABAergic inhibitory neuron development as well. However, the molecular pathways which acts on neurons, whether they are similar or different from mechanisms underlying its effects unknown. Here, we examined whether, how, embryonic-onset haploinsufficiency restricted interneurons derived medial ganglionic eminence (MGE) impacts their synaptic intrinsic properties adult primary auditory cortex (A1). We found affects properties, overall leading increased firing threshold, decreased drive Parvalbumin (PV)+ Layer IV A1, whilst Somatostatin (SST)+ were mostly resistant haploinsufficiency. Further, AMPA component thalamocortical evoked-EPSC was PV+ cells mutant mice. Finally, selective blocking voltage-gated D-type K+ currents sufficient rescue cell-intrinsic wild-type levels. Together, these data specific maturation cell drive, may lead reduced PV recruitment could turn contribute alterations SYNGAP1-ID preclinical models patients.

Language: Английский

Rev or restrain: Mechanisms of human-specific synaptic neoteny DOI
Jenelle L. Wallace, Alex A. Pollen

Neuron, Journal Year: 2024, Volume and Issue: 112(21), P. 3519 - 3521

Published: Nov. 1, 2024

Language: Английский

Citations

0
Syngap1 regulates the synaptic drive and membrane excitability of Parvalbumin-positive interneurons in mouse auditory cortex DOI Open Access
Ruggiero Francavilla,

Bidisha Chattopadhyaya,

Jorelle Linda Damo Kamda

et al.

Published: May 1, 2024

SYNGAP1 haploinsufficiency-related intellectual disability (SYNGAP1-ID) is characterized by moderate to severe ID, generalized epilepsy, autism spectrum disorder, sensory processing dysfunction and other behavioral abnormalities. While numerous studies have highlighted a role of Syngap1 in cortical excitatory neurons development; recent suggest that plays GABAergic inhibitory neuron development as well. However, the molecular pathways which acts on neurons, whether they are similar or different from mechanisms underlying its effects unknown. Here, we examined whether, how, embryonic-onset haploinsufficiency restricted interneurons derived medial ganglionic eminence (MGE) impacts their synaptic intrinsic properties adult primary auditory cortex (A1). We found affects properties, overall leading increased firing threshold, decreased drive Parvalbumin (PV)+ Layer IV A1, whilst Somatostatin (SST)+ were mostly resistant haploinsufficiency. Further, AMPA component thalamocortical evoked-EPSC was PV+ cells mutant mice. Finally, selective blocking voltage-gated D-type K+ currents sufficient rescue cell-intrinsic wild-type levels. Together, these data specific maturation cell drive, may lead reduced PV recruitment could turn contribute alterations SYNGAP1-ID preclinical models patients.

Language: Английский

Citations

0