Actinomyces viscosus promotes neuroprotection in C. elegans models of Parkinson’s disease DOI

G Sophie Ngana,

Matteo Di Bernardo, Michael G. Surette

et al.

Mechanisms of Ageing and Development, Journal Year: 2025, Volume and Issue: unknown, P. 112061 - 112061

Published: April 1, 2025

Language: Английский

The life and times of brain autophagic vesicles DOI
Lisa Gambarotto, Erin Wosnitzka, Vassiliki Nikoletopoulou

et al.

Journal of Molecular Biology, Journal Year: 2025, Volume and Issue: unknown, P. 169105 - 169105

Published: March 1, 2025

Language: Английский

Citations

0
Beneficial effects of mitophagy enhancers on amyloid beta-induced mitochondrial and synaptic toxicities in Alzheimer’s disease DOI
Sudhir Kshirsagar, Arubala P. Reddy, P. Hemachandra Reddy

et al.

Mitochondrion, Journal Year: 2025, Volume and Issue: 83, P. 102038 - 102038

Published: March 29, 2025

Language: Английский

Citations

0
BIOLOGICALLY SUBSTANTIATED, SAFE, AND CORRECTIVE REMEDIES FOR SARS-COV-2 REGIMEN DOI

M. F. Amirova,

E. E. Huseynova,

N. V. Melikova

et al.

World of Medicine and Biology, Journal Year: 2025, Volume and Issue: 21(91), P. 212 - 212

Published: Jan. 1, 2025

Language: Английский

Citations

0
Unraveling the cGAS-STING pathway in Alzheimer’s disease: A new Frontier in neuroinflammation and therapeutic strategies DOI
Arshdeep Kaur, Khadga Raj Aran

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Sanshen San Formula Hinders Cognitive Function and Pathology in Alzheimer's Disease Through Potentiating the Function of Synapse DOI Creative Commons
Shiquan Chang,

Nana Ding,

Yalin Li

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(4)

Published: April 1, 2025

ABSTRACT Background Alzheimer's disease ( AD ) constitutes a devastating neurodegenerative disorder, manifested by amyloid‐β aggregation, phosphorylated tau accumulation, and progressive cognitive deterioration. Current therapeutic interventions remain predominantly symptomatic, underscoring the urgency for more efficacious treatment strategies. Purpose This study elucidated potential of Sanshen San (SSS), traditional Chinese herbal formula encompassing Polygala Radix , Pini in Poria Acori Tatarinowii Rhizoma on function pathology. Methods We implemented both acute Aβ 1‐42 ‐injected mice 5xFAD transgenic mouse models. The efficacy SSS was assessed through behavioral paradigms including Y‐maze, Novel Object Recognition, Morris Water Maze. Molecular mechanisms were delineated utilizing RNA sequencing, metabolomics analysis, immunofluorescence staining, Golgi‐Cox transmission electron microscopy, Western blotting. Results Chemical analysis unveiled 10 principal bioactive compounds SSS. substantially ameliorated performance models, attenuated plaque burden, augmented microglial phagocytosis. safeguarded synaptic integrity, enhanced mitochondrial function, facilitated autophagy. Transcriptomic metabolomic analyses demonstrated that operates reinstating neurotransmitter particularly dopaminergic system. Conclusion efficaciously mitigates pathology potentiating optimizing homeostasis, restoring balance, exemplifying promising multi‐target strategy .

Language: Английский

Citations

0
Roles of HSP70 in autophagic protection of cardiomyocytes induced by heat acclimation: A review DOI
Yue Huang, Guoyu Li, Shuwan Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142984 - 142984

Published: April 1, 2025

Language: Английский

Citations

0
Microsatellite expansions hidden within the human dark genome are translated in novel and toxic proteins causing muscle and neurodegenerative diseases DOI
Nicolas Charlet‐Berguerand, Manon Boivin, Jiaxi Yu

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Abstract The vast majority of the human genome is non-coding with one-half composed repeated DNA elements, including microsatellites that are short sequences 1 to 6 nucleotides. Expansion a subset these leading cause over 60 neurological diseases. However, most tandem repeat expansions located in annotated as non-coding, thus questioning how mutations pathogenic. Here, we found GGC causing various diseases, oculopharyngodistal myopathy or without leukoencephalopathy (OPDM/OPML) and neuronal intranuclear inclusion disease (NIID), while embedded considered reality within small previously unrecognized ORFs, resulting their translation into novel diverse polyglycine-containing proteins. Antibodies developed against proteins stain p62-positive inclusions typical Importantly, sole expression recapitulates key features OPDM/OPML/NIID, namely formation protein aggregates locomotor skeletal muscle alterations associated neurodegeneration cell, fly mouse models. Moreover, polyglycine show unexpected variations interactants, half-life, aggregation toxicity. These results stress role specific ORF hosting repeats modulate toxic properties central core. Finally, identified pharmacological compound targeting proteins, raising hope develop common therapy for neuromuscular neurodegenerative Overall, uncover unified pathogenic mechanism diseases where translated driving aggregates, well cell dysfunctions. this work highlights complexity richness “dark” proteome importance yet ORFs pathologies.

Language: Английский

Citations

0
Actinomyces viscosus promotes neuroprotection in C. elegans models of Parkinson’s disease DOI

G Sophie Ngana,

Matteo Di Bernardo, Michael G. Surette

et al.

Mechanisms of Ageing and Development, Journal Year: 2025, Volume and Issue: unknown, P. 112061 - 112061

Published: April 1, 2025

Language: Английский

Citations

0