Brain circuits that regulate social behavior DOI Creative Commons
Hao Li, Zhe Zhao,

Shaofei Jiang

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Social interactions are essential for the survival of individuals and reproduction populations. stressors, such as social defeat isolation, can lead to emotional disorders cognitive impairments. Furthermore, dysfunctional behaviors hallmark symptoms various neuropsychiatric disorders, including autism spectrum disorder (ASD) post-traumatic stress (PTSD). Consequently, understanding neural circuit mechanisms underlying has become a major focus in neuroscience. behaviors, which encompass wide range expressions phases, regulated by complex networks. In this review, we summarize recent progress identifying circuits involved different types general investigation, preference, mating, aggression, parenting, prosocial dominance behaviors. We also outline associated with deficits ASD, schizophrenia, PTSD. Given pivotal role rodents behavior research, our review primarily focuses on these animals. Finally, propose future research directions, development specific behavioral paradigms, identification motor output, integration activity, transcriptome, connectome data, multifunctional roles neurons multiple targets, among brain regions.

Language: Английский

Circuit control of competition DOI
Katherine Whalley

Nature reviews. Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

Citations

0
Opposing and segregated cortical circuits control winning and losing behaviors DOI

Elizabeth Illescas-Huerta,

Nancy Padilla-Coreano

Neuron, Journal Year: 2025, Volume and Issue: 113(3), P. 335 - 336

Published: Feb. 1, 2025

Language: Английский

Citations

0
Neural mechanisms underlying strain preference behaviour and plasticity in mice DOI Creative Commons

Kaizhen Peng,

Lili Tan,

Shiyu You

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 24, 2025

All social animals, including humans, have different identities that generate unique interactions. Social preference behaviours, integration, prosocial behaviour, and cooperation, a wide impact on an individual's life. However, the neural mechanisms underlying preferences are not yet clear. In this study, using mice as model we investigated strain preference, which is based identification. We revealed, for first time, behaviour of heterogeneous; is, C57 prefer to interact with same strain, whereas KM strain. further confirmed in can be plastically altered by changing nurturing environment increasing exposure other strains. Finally, screened brain regions related mouse revealed activity periaqueductal grey (PAG) was only consistent both but also coordinated alteration preference. subsequently used muscarine inhibit PAG C57BL/6J found strain-specific disappeared. These results showed key region regulating its plasticity. This work fills gap study research.

Language: Английский

Citations

0
Brain circuits that regulate social behavior DOI Creative Commons
Hao Li, Zhe Zhao,

Shaofei Jiang

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Social interactions are essential for the survival of individuals and reproduction populations. stressors, such as social defeat isolation, can lead to emotional disorders cognitive impairments. Furthermore, dysfunctional behaviors hallmark symptoms various neuropsychiatric disorders, including autism spectrum disorder (ASD) post-traumatic stress (PTSD). Consequently, understanding neural circuit mechanisms underlying has become a major focus in neuroscience. behaviors, which encompass wide range expressions phases, regulated by complex networks. In this review, we summarize recent progress identifying circuits involved different types general investigation, preference, mating, aggression, parenting, prosocial dominance behaviors. We also outline associated with deficits ASD, schizophrenia, PTSD. Given pivotal role rodents behavior research, our review primarily focuses on these animals. Finally, propose future research directions, development specific behavioral paradigms, identification motor output, integration activity, transcriptome, connectome data, multifunctional roles neurons multiple targets, among brain regions.

Language: Английский

Citations

0