The Brain in the Gut: Enteric Nervous System and Its Clinical Relevance

National Journal of Clinical Anatomy, Journal Year: 2025, Volume and Issue: 14(1), P. 1 - 3

Published: Jan. 1, 2025

Language: Английский

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Shank3 mutation manifests in abnormal gastrointestinal morphology and function in mice

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 17, 2025

Gastrointestinal (GI) comorbidities are common among those with Autism Spectrum Disorder (ASD), but their etiology is not well understood. This study aimed to characterize gastrointestinal morphology and function in Shank3B mutant mice, a genetic model of ASD, identify potential alterations the GI tract that could underlie ASD-associated comorbidities. enteric nervous system was characterized using Hematoxylin Eosin staining immunohistochemistry. permeability measured FITC-Dextran paracellular assay. Whole-GI motility time vivo carmine dye Colonic contractions were by tracking an ex Homozygous knock-out (KO) Shank3B-/- mice exhibit significantly altered epithelial increased permeability. An myenteric plexus density higher number HuC/D-expressing neurons ganglia observed colon mice. These slowed whole-GI transit reduced velocity propagation length colonic contractions. Compared heterozygous Shank3B+/- milder epithelial, neuronal, functional alterations. function, while partial phenotype. results indicate Shank3, whose mutation associated critical for its may contribute

Language: Английский

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Great minds think alike: Glutamatergic signaling in the second brain

Neuron, Journal Year: 2025, Volume and Issue: 113(7), P. 965 - 968

Published: April 1, 2025

Language: Английский

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