Role of Achyranthes aspera in neurodegenerative diseases: current evidence and future directions DOI Creative Commons
Huaiqing Luo,

S.H.Y. Wei,

Shujun Fu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 9, 2025

Neurodegenerative diseases are caused by the progressive degeneration of neurons and/or their myelin sheaths, ultimately leading to cognitive and motor dysfunction. Due complex pathogenesis limited efficacy therapeutic drugs, these have attracted significant attention. Achyranthes aspera, belongs family Amaranthaceae, has been extensively used in traditional folk medicines for treatment various ailments. Modern research revealed that aspera possesses pharmacological effects, including cardiocerebrovascular protection, immune regulation, antioxidation, anti-aging. Furthermore, neuroprotective effects confirmed numerous scientific studies. This review focuses on primary mechanisms prevention neurodegenerative diseases, as well potential application prospects. aims provide insights into clinical applications directions diseases.

Language: Английский

BACE1 regulates sleep–wake cycle through both enzymatic and non–enzymatic actions DOI

Hannah Heininger,

Xiao Feng,

Alp Altunkaya

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Abstract The β-secretase BACE1 has become a prime target in Alzheimer’s disease (AD) therapy, because it drives the production of pathogenic amyloid β peptides. However, clinical trials with BACE1-targeting drugs were halted due to adverse effects on cognitive performance. We propose here that impairment by inhibitors may be corollary higher function related proper sleep regulation. To address non-enzymatic ion channels likely involved sleep–wake cycle, we analyzed patterns both BACE1-KO mice and newly generated transgenic line expressing proteolysis-deficient variant (BACE1-KI). found BACE1-KI displayed common distinct disturbances. Compared their respective wild-type littermates, mutant lines slept less during light phase (when they preferentially rest). Furthermore, transition rates between wake states altered, as spindles EEG power spectra gamma range. Thus, better understanding how interferes sleep-modulated behaviors is needed if BACE1-targeted are resume.

Language: Английский

Citations

0
Role of Achyranthes aspera in neurodegenerative diseases: current evidence and future directions DOI Creative Commons
Huaiqing Luo,

S.H.Y. Wei,

Shujun Fu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 9, 2025

Neurodegenerative diseases are caused by the progressive degeneration of neurons and/or their myelin sheaths, ultimately leading to cognitive and motor dysfunction. Due complex pathogenesis limited efficacy therapeutic drugs, these have attracted significant attention. Achyranthes aspera, belongs family Amaranthaceae, has been extensively used in traditional folk medicines for treatment various ailments. Modern research revealed that aspera possesses pharmacological effects, including cardiocerebrovascular protection, immune regulation, antioxidation, anti-aging. Furthermore, neuroprotective effects confirmed numerous scientific studies. This review focuses on primary mechanisms prevention neurodegenerative diseases, as well potential application prospects. aims provide insights into clinical applications directions diseases.

Language: Английский

Citations

0