Alcohol Withdrawal Alters the Inhibitory Landscape of the Prelimbic Cortex in an Interneuron- and Sex-specific Manner DOI Open Access
Sema G. Quadir,

Shane Zaidi,

M. G. Cone

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

ABSTRACT Alcohol use disorder (AUD) is highly prevalent and associated with substantial morbidity high mortality among substance disorders. While there are currently three FDA-approved medications for treating AUDs, none specifically target the withdrawal/negative affect stage of AUD, underscoring need to understand underlying neurobiology during this critical addiction cycle. One key region involved in alcohol withdrawal negative prelimbic cortex, a subregion medial prefrontal cortex. previous studies have examined alcohol-related adaptations cortical principal glutamatergic neurons, here we used male female PV:Ai14, SOM:Ai14 VIP:Ai14 mice examine synaptic all major classes cortex interneurons following 72 hour from continuous access two bottle choice model EtOH drinking mice. We found that increased excitability PV males, but decreased VIP females. Additionally, reduced GABA release onto males while increasing glutamate In SOM interneurons, had no effect on excitability, males. Together, our identified sex-specific withdrawal-induced plasticity different types could provide insight into cellular substrates affective states withdrawal.

Language: Английский

Endogenous opiates and behavior: 2023 DOI
Richard J. Bodnar

Peptides, Journal Year: 2024, Volume and Issue: 179, P. 171268 - 171268

Published: June 28, 2024

Language: Английский

Citations

6
Alcohol Withdrawal Alters the Inhibitory Landscape of the Prelimbic Cortex in an Interneuron- and Sex-specific Manner DOI Open Access
Sema G. Quadir,

Shane Zaidi,

M. G. Cone

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

ABSTRACT Alcohol use disorder (AUD) is highly prevalent and associated with substantial morbidity high mortality among substance disorders. While there are currently three FDA-approved medications for treating AUDs, none specifically target the withdrawal/negative affect stage of AUD, underscoring need to understand underlying neurobiology during this critical addiction cycle. One key region involved in alcohol withdrawal negative prelimbic cortex, a subregion medial prefrontal cortex. previous studies have examined alcohol-related adaptations cortical principal glutamatergic neurons, here we used male female PV:Ai14, SOM:Ai14 VIP:Ai14 mice examine synaptic all major classes cortex interneurons following 72 hour from continuous access two bottle choice model EtOH drinking mice. We found that increased excitability PV males, but decreased VIP females. Additionally, reduced GABA release onto males while increasing glutamate In SOM interneurons, had no effect on excitability, males. Together, our identified sex-specific withdrawal-induced plasticity different types could provide insight into cellular substrates affective states withdrawal.

Language: Английский

Citations

0