Mediating role of gut microbiota on Baduanjin for cognitive function in community-dwelling older adults with mild cognitive impairment: a study protocol for a cluster randomised controlled trial DOI Creative Commons
L. Sun, Geng Qian,

Guohua Zheng

et al.

BMJ Open, Journal Year: 2024, Volume and Issue: 14(11), P. e087684 - e087684

Published: Nov. 1, 2024

Introduction The gut microbiome plays an important role in maintaining both cognitive and physical functions older adults, dysbiosis is pathophysiological mechanism of mild impairment (MCI) adults. As a typical traditional Chinese mind-body exercise, regular Baduanjin training has been shown to improve function modulate the community-dwelling However, potential benefits on remains unclear. aim this study investigate mediating effect between improvement adults with MCI. Methods analysis This two-arm, randomised, parallel-controlled, single-blinded trial. Four residential communities (clusters) total 64 eligible participants (16 each community) will be randomised 1:1 either 24-week exercise intervention group (60 min per session, four sessions week) or no specific control group. Global subdimensions cognition including executive function, visuospatial language memory assessed using Montreal Cognitive Assessment Scale, Trail Making Test, Auditory Verbal Learning Boston Naming Test-30 Clock-Drawing while its metabolomics detected 16S rRNA ultra-high-performance liquid chromatography–tandem mass spectrometry at baseline end intervention. microbiota analysed linear mixed models bootstrapping method Hayes process. Ethics dissemination conforms Declaration Helsinki principles relevant ethical guidelines. Ethical approval obtained from Committee Shanghai University Medicine Health Sciences (approval number: 2023-GZR-011). Written informed consent all participants. Results disseminated groups peer-reviewed journal(s), international national scientific conferences. Key findings also shared social media, healthcare providers, support access for non-research audiences. Trial registration number ChiCTR2300078147.

Language: Английский

Gut Microbiome Modulation of Innate Immunity in Neurodegenerative Diseases DOI
Andrea R. Merchak, Kelly B. Menees, MacKenzie L. Bolen

et al.

Oxford University Press eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Abstract The intimate connections among the gut, immune system, and brain have become increasingly apparent in recent years. Alterations gut microbiome been reported several neurodegenerative diseases including Alzheimer’s disease, Parkinson’s multiple sclerosis. Moreover, evidence also points to innate system involvement pathogenesis of these diseases. Given that is largest organ body, understanding dynamic interplay between how this influences health disease critical. Further microbiome, their interactions are altered may be key developing disease-modifying therapies. This chapter reviews literature related microbiome-derived mediators impact on context external factors, diet, pre-/probiotics, exercise, caffeine, smoking, immunity discussed.

Language: Английский

Citations

0
Mediating role of gut microbiota on Baduanjin for cognitive function in community-dwelling older adults with mild cognitive impairment: a study protocol for a cluster randomised controlled trial DOI Creative Commons
L. Sun, Geng Qian,

Guohua Zheng

et al.

BMJ Open, Journal Year: 2024, Volume and Issue: 14(11), P. e087684 - e087684

Published: Nov. 1, 2024

Introduction The gut microbiome plays an important role in maintaining both cognitive and physical functions older adults, dysbiosis is pathophysiological mechanism of mild impairment (MCI) adults. As a typical traditional Chinese mind-body exercise, regular Baduanjin training has been shown to improve function modulate the community-dwelling However, potential benefits on remains unclear. aim this study investigate mediating effect between improvement adults with MCI. Methods analysis This two-arm, randomised, parallel-controlled, single-blinded trial. Four residential communities (clusters) total 64 eligible participants (16 each community) will be randomised 1:1 either 24-week exercise intervention group (60 min per session, four sessions week) or no specific control group. Global subdimensions cognition including executive function, visuospatial language memory assessed using Montreal Cognitive Assessment Scale, Trail Making Test, Auditory Verbal Learning Boston Naming Test-30 Clock-Drawing while its metabolomics detected 16S rRNA ultra-high-performance liquid chromatography–tandem mass spectrometry at baseline end intervention. microbiota analysed linear mixed models bootstrapping method Hayes process. Ethics dissemination conforms Declaration Helsinki principles relevant ethical guidelines. Ethical approval obtained from Committee Shanghai University Medicine Health Sciences (approval number: 2023-GZR-011). Written informed consent all participants. Results disseminated groups peer-reviewed journal(s), international national scientific conferences. Key findings also shared social media, healthcare providers, support access for non-research audiences. Trial registration number ChiCTR2300078147.

Language: Английский

Citations

0