Piezo1 Modulates Neuronal Autophagy and Apoptosis in Cerebral Ischemia–Reperfusion Injury Through the AMPK-mTOR Signaling Pathway

Neurochemical Research, Journal Year: 2024, Volume and Issue: 50(1)

Published: Nov. 25, 2024

Language: Английский

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GsMTx-4 combined with exercise improves skeletal muscle structure and motor function in rats with spinal cord injury

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0317683 - e0317683

Published: Jan. 22, 2025

Motor dysfunction and muscle atrophy are typical symptoms of patients with spinal cord injury (SCI). Exercise training is a conventional physical therapy after SCI, but exercise intervention alone may have limited efficacy in reducing secondary promoting nerve regeneration functional remodeling. Our previous research found that intramedullary pressure SCI one the key factors affecting prognosis. It has been reported GsMTx-4, specific blocker mechanosensitive ion channels Piezo1, can protect integrity neuromuscular junction promote regeneration, thus potential as therapeutic agent for SCI. In this study, we observed combined separate effect GsMTx-4 on structure soleus motor function rats At 42 days post-injury, compared rats, Basso–Beattie–Bresnahan score (P = 0.0007) Gait Symmetry 0.0002) were significantly improved combination therapy. On histology rat muscle, treatment increased wet weight ratio, fiber cross-sectional area acetylcholinesterase (all P<0.0001). tissue, neuron counts BDNF levels, reduced percentage TUNEL-positive cells physiology succinate dehydrogenase expression (P<0.0001), while α-glycerophosphate (P<0.0001) GDF8 protein 0.0008) decreased. Results indicate effectively improves histopathology enhancing function. This study was conducted animal models, it offers insights treatment, advancing understanding lower limb pathology post-SCI. Further needed clinical validation future.

Language: Английский

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Mechanotransduction in Development: A Focus on Angiogenesis

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 346 - 346

Published: March 27, 2025

Cells respond to external mechanical cues and transduce these forces into biological signals. This process is known as mechanotransduction requires a group of proteins called mechanosensors. peculiar class receptors include extracellular matrix proteins, plasma membrane the cytoskeleton nuclear envelope. These cell components are responsive wide spectrum physical including stiffness, tensile force, hydrostatic pressure shear stress. Among mechanotransducers, Transient Receptor Potential (TRP) PIEZO family members mechanosensitive ion channels, coupling force transduction with intracellular cation transport. Their activity contributes embryo development, tissue remodeling repair, homeostasis. In particular, vessel development driven by hemodynamic such flow direction Perturbed involved in several pathological vascular phenotypes hereditary hemorrhagic telangiectasia. review conceived summarize most recent findings development. We first collected main features proteins. However, we focused on role during Mechanosensitive channels their function also discussed, focus brain morphogenesis.

Language: Английский

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Piezo1 is a Pathogenic Gene and Therapeutic Target for Neurological Diseases

International Journal of Neuroscience, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 23

Published: April 25, 2025

Piezo1 is a ubiquitously expressed non-selective cation channel protein found across various species. It possesses the ability to detect and respond external mechanical forces, converting cues into intracellular bioelectrical events, thereby facilitating propagation of electrochemical signals. Within nervous system, integral synaptogenesis myelination, modulation pro-inflammatory mediators, neuropathic pain, cognitive processes, angiogenesis, regulation cerebral hemodynamics, consequently impacting pathogenesis progression neurological disorders. This review meticulously summarizes synthesizes existing literature provide an exhaustive overview Piezo1's roles mechanisms in spectrum diseases, including neurodegenerative disorders, cerebrovascular accidents, traumatic brain injuries, gliomas, multiple sclerosis, epilepsy. Additionally, it explores potential therapeutic applications targeting Piezo1. The discussion also encompasses current research limitations, imperative need for future investigations, prospective strategies. Our analysis indicates that susceptibility gene conditions, its expression inhibition may confer benefits. In summary, this comprehensive offers novel insights involvement diseases establishes theoretical groundwork development Piezo1-targeted interventions.

Language: Английский

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The key role of Piezo1 channels in ferroptosis after spinal cord injury and the therapeutic potential of Piezo1 inhibitors

Progress in Biophysics and Molecular Biology, Journal Year: 2025, Volume and Issue: 196, P. 132 - 140

Published: May 6, 2025

Language: Английский

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miRNA506 Activates Sphk1 Binding with Sirt1 to Inhibit Brain Injury After Intracerebral Hemorrhage via PI3K/AKT Signaling Pathway

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 12, 2024

Language: Английский

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GsMTx4 Combined with Exercise Exerts Neuroprotective Effects by Regulating Neuronal Autophagy in Rats with Spinal Cord Injury

Neurochemical Research, Journal Year: 2024, Volume and Issue: 50(1)

Published: Dec. 12, 2024

Language: Английский

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