Inflammation, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 19, 2024
Language: Английский
Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 981 - 1000
Published: Feb. 1, 2025
Esketamine ameliorates propofol-induced brain damage and cognitive impairment in mice. However, the precise role underlying mechanism of esketamine perioperative neurocognitive disorders (PND) remain unclear. Therefore, this study aimed to investigate key genes associated with PND through animal modeling transcriptome sequencing. The present established a mice model administered intervention model, were divided into control, surgical group, group esketamine. Behavioral assessments conducted using Morris water maze Y paradigms, while sequencing was performed on hippocampal samples obtained from 3 groups. Differential expression analysis weighted gene co-expression network (WGCNA) data identify candidate related treating PND. Thereafter, protein-protein interaction (PPI) implemented select genes. each step subjected enrichment analysis, regulatory for constructed. findings demonstrated successful construction our indicated that exhibits certain therapeutic efficacy Ank1, Cbln4, L1cam, Gap43, Shh designated as subsequent analysis. 5 significantly enriched cholesterol biosynthesis, nonsense mediated decay (NMD), formation pool free 40s subunits, major pathway rRNA processing nucleolus cytosol, among others. Notably, miRNAs, mmu-mir-155-5p mmu-mir-1a-3p, functionally co-regulated L1cam. We uncovered identified (Ank1, Shh) contribute its effects, providing valuable reference further mechanistic studies esketamine's treatment
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 157, P. 114746 - 114746
Published: April 28, 2025
Language: Английский
Citations
0
Inflammation, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 19, 2024
Language: Английский
Citations
1