The zona incerta regulates burying behavior and normalizes anxiety-like behavior in inescapable stressful male mice by object cue DOI Creative Commons

Yueqin Liu,

Lianli Qiu,

Jiahui Qian

et al.

Neurobiology of Stress, Journal Year: 2024, Volume and Issue: 34, P. 100704 - 100704

Published: Dec. 17, 2024

Inescapable stressful events often precipitate long-term alterations in emotion-related behaviors and poor sleep quality, with anxiety being a prevalent associated disorder. The defensive burying behavior of rodents is response to imminent threats that becomes markedly pronounced anxiety. However, the neural foundations etiology remain largely unknown. In this study, we established model employing object binding elicit increased mice, thereby enhancing fear resolution subsequently reducing anxious behaviors. Notably, mice shock an exhibited less exploration zona incerta (ZI) neurons showed higher calcium activity during as compared Shock only mice. Although ZI Object was identical more behavior. Furthermore, time spent center open-field test directly proportional duration Chemogenetic activation extended concomitantly ameliorated anxiety-like Importantly, chemogenetic enhancement projection from ventral periaqueductal gray (vPAG), brain region plays critical role autonomic function, normalizes without influencing Collectively, these findings systematically reveal functions underlying mechanisms ZI-vPAG circuit controlling akin anxiety, offering significant insights into ZI's pathophysiology disorders.

Language: Английский

The parasubthalamic nucleus: A novel eating center in the brain DOI
Mingxuan Lu, Jiayao Zhang, Qi Zhang

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: 136, P. 111250 - 111250

Published: Jan. 1, 2025

Language: Английский

Citations

0
Differentiation and regulation of CD4+ T cell subsets in Parkinson’s disease DOI Creative Commons
Xiaowei Sun,

Rou Gu,

Jie Bai

et al.

Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)

Published: Aug. 17, 2024

Parkinson's disease (PD) is the second most common neurodegenerative disease, and its hallmark pathological features are loss of dopaminergic (DA) neurons in midbrain substantia nigra pars compacta (SNpc) accumulation alpha-synuclein (α-syn). It has been shown that integrity blood-brain barrier (BBB) damaged PD patients, a large number infiltrating T cells inflammatory cytokines have detected cerebrospinal fluid (CSF) brain parenchyma patients animal models, including significant change proportion different CD4

Language: Английский

Citations

3
The zona incerta regulates burying behavior and normalizes anxiety-like behavior in inescapable stressful male mice by object cue DOI Creative Commons

Yueqin Liu,

Lianli Qiu,

Jiahui Qian

et al.

Neurobiology of Stress, Journal Year: 2024, Volume and Issue: 34, P. 100704 - 100704

Published: Dec. 17, 2024

Inescapable stressful events often precipitate long-term alterations in emotion-related behaviors and poor sleep quality, with anxiety being a prevalent associated disorder. The defensive burying behavior of rodents is response to imminent threats that becomes markedly pronounced anxiety. However, the neural foundations etiology remain largely unknown. In this study, we established model employing object binding elicit increased mice, thereby enhancing fear resolution subsequently reducing anxious behaviors. Notably, mice shock an exhibited less exploration zona incerta (ZI) neurons showed higher calcium activity during as compared Shock only mice. Although ZI Object was identical more behavior. Furthermore, time spent center open-field test directly proportional duration Chemogenetic activation extended concomitantly ameliorated anxiety-like Importantly, chemogenetic enhancement projection from ventral periaqueductal gray (vPAG), brain region plays critical role autonomic function, normalizes without influencing Collectively, these findings systematically reveal functions underlying mechanisms ZI-vPAG circuit controlling akin anxiety, offering significant insights into ZI's pathophysiology disorders.

Language: Английский

Citations

1