
Journal of Comparative Physiology A, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 20, 2024
Language: Английский
Journal of Comparative Physiology A, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 20, 2024
Language: Английский
Biology of Sex Differences, Journal Year: 2025, Volume and Issue: 16(1)
Published: May 25, 2025
Abstract Background The cerebrospinal fluid (CSF) is known to serve as a unique environment for neurodevelopment, with specific proteins secreted by epithelial cells of the choroid plexus (CP) playing crucial roles in cortical development and cell differentiation. Sex-related differences brain early life have been widely identified, but few studies investigated neonatal CSF system associated transcriptional signatures. Methods This study included 75 full-term neonates [44 males 31 females; gestational age (GA) = 37–42 weeks] without significant MRI abnormalities from dHCP (developing Human Connectome Project) database. Deep-learning automated segmentation was used measure various metrics ventricular CSF. relationships postnatal were analyzed linear regression. Correlations between CP space also examined. LASSO regression further applied identify key genes contributing sex-related using regional gene expression data Allen Brain Atlas. Results Right lateral ventricles [2.42 ± 0.98 vs. 2.04 0.45 cm3 (mean standard deviation), p 0.036] right (0.16 0.07 0.13 0.04 cm3, 0.024) larger males, stronger volume correlation (male/female coefficients r: 0.798 0.649, < 1 × 10 − 4 ). No difference found total volume, while peripheral β: 1.218 1.064) 0.008 0.005) exhibited relatively faster growth males. Additionally, volumes system, third ventricle, CSF, significantly correlated their corresponding (r: 0.362 0.799, 0.05). DERL2 (Degradation Endoplasmic Reticulum Protein 2) ( r 0.1319) MRPL48 (Mitochondrial Large Ribosomal Subunit Protein) =-0.0370) identified potential system. Conclusion Male present likely linked pattern. downregulation upregulation may contribute these variations suggesting molecular basis sex-specific development.
Language: Английский
Citations
0Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
0Journal of Comparative Physiology A, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 20, 2024
Language: Английский
Citations
0