Cross-disease drug discovery based on bioinformatics and virtual screening: Study of key genes in Alzheimer’s disease and ovarian cancer DOI

Ziyi Shen,

Jinxuan Song, Shenglin Wang

et al.

Gene, Journal Year: 2024, Volume and Issue: 935, P. 149084 - 149084

Published: Nov. 8, 2024

Language: Английский

Comparison between Cannabidiol and Fluoxetine effects on chronic neuropathic pain and depression comorbid in rats DOI
Daimio C. Brito, Ana Carolina Medeiros, Christie Ramos Andrade Leite‐Panissi

et al.

Neuroscience and Behavioral Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Language: Английский

Citations

0
Cannabidiol reduces neuropathic pain and cognitive impairments through activation of spinal PPARγ DOI
Ana M. Islas-Espinoza, Itzel I. Ramos-Rodríguez, María José Escoto-Rosales

et al.

Journal of Pain, Journal Year: 2025, Volume and Issue: unknown, P. 105378 - 105378

Published: March 1, 2025

Language: Английский

Citations

0
FATS inhibits the Wnt pathway and induces apoptosis through degradation of MYH9 and enhances sensitivity to paclitaxel in breast cancer DOI Creative Commons
Jinxuan Song, Yue Wang,

Zhipeng Hua

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(11)

Published: Nov. 16, 2024

Abstract Breast cancer is one of the most prevalent and diverse malignancies, and, with global cases increasing, need for biomarkers to inform individual sensitivity chemotherapeutics has never been greater. Our retrospective clinical analysis predicted that expression fragile site-associated tumor suppressor (FATS) gene was associated breast neoadjuvant chemotherapy paclitaxel. In vitro experiments subsequently demonstrated FATS significantly increased inhibitory effects paclitaxel on cells’ migration, growth, survival. An interaction screen revealed interacted MYH9 promoted its degradation via ubiquitin-proteasome pathway, thereby downregulating Wnt signaling. By overexpressing MYH9, we enhanced paclitaxel-induced apoptosis in cells by degrading downregulate pathway. We also a mouse xenograft model chemosensitivity vivo. This study presents new mechanism which interacts suppress Wnt/β-catenin signaling pathway induce apoptosis, thus enhancing chemotherapy. The results propose novel predicting Finally, provide vivo evidence combination IWR-1, inhibitor, synergistically suppresses laying foundation future trials this drug combination. These therefore number potential solutions more precise treatment patients future.

Language: Английский

Citations

1
Cross-disease drug discovery based on bioinformatics and virtual screening: Study of key genes in Alzheimer’s disease and ovarian cancer DOI

Ziyi Shen,

Jinxuan Song, Shenglin Wang

et al.

Gene, Journal Year: 2024, Volume and Issue: 935, P. 149084 - 149084

Published: Nov. 8, 2024

Language: Английский

Citations

0