Lactoferrin as a Candidate Multifunctional Therapeutic in Synucleinopathies DOI Creative Commons
Caroline A. Barros, Tuane C. R. G. Vieira

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(4), P. 380 - 380

Published: April 6, 2025

Lactoferrin (Lf) is a multifunctional glycoprotein with well-established antimicrobial, anti-inflammatory, and iron-binding properties. Emerging evidence suggests that Lf also plays neuroprotective role, particularly in neurodegenerative disorders characterized by protein aggregation, such as Parkinson’s disease (PD). Alpha-synuclein (aSyn) aggregation pathological hallmark of PD other synucleinopathies, contributing to neuronal dysfunction progression. Recent studies indicate may interfere aSyn iron chelation, modulation oxidative stress neuroinflammation. Additionally, Lf’s ability cross the blood-brain barrier its potential impact on gut-brain axis highlight promise therapeutic agent. This review explores mechanisms action disease-modifying therapy, innovative delivery strategies could enhance clinical applicability. By addressing dimensions we propose compelling candidate for future research development diseases.

Language: Английский

Broadening horizons: research on ferroptosis in lung cancer and its potential therapeutic targets DOI Creative Commons
Guangpeng Gao, Xindi Zhang

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 23, 2025

Ferroptosis is a novel form of cell death distinct from traditional mechanisms, characterized by the accumulation iron ions and production lipid peroxides. It not only affects survival tumor cells but also closely linked to changes in microenvironment. Lung cancer one leading malignancies worldwide terms incidence mortality, its complex biological mechanisms resistance make treatment challenging. Recent studies have shown that ferroptosis plays key role onset progression lung cancer, with intricate regulatory influencing development response therapy. As research into deepens, related molecular pathways, such as glutamate metabolism, antioxidant defense, been gradually revealed. However, clinical practice, ferroptosis-based therapeutic strategies for are still their early stages. Challenges remain, including incomplete understanding specific ferroptosis, insufficient on factors, limited insight interactions within Therefore, effective modulation enhance remains an urgent issue. This review summarizes analyzes factors interaction microenvironment, further explores potential targeting ferroptosis. By synthesizing latest research, this paper aims provide new perspectives directions treatment, goal advancing applications.

Language: Английский

Citations

0
Status epilepticus alters hippocampal ultrastructure in kainic acid rat model DOI
Mzia G. Zhvania,

Irina Sharikadze,

Nadezhda Japaridze

et al.

Tissue and Cell, Journal Year: 2025, Volume and Issue: 94, P. 102789 - 102789

Published: Feb. 10, 2025

Language: Английский

Citations

0
Lactoferrin as a Candidate Multifunctional Therapeutic in Synucleinopathies DOI Creative Commons
Caroline A. Barros, Tuane C. R. G. Vieira

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(4), P. 380 - 380

Published: April 6, 2025

Lactoferrin (Lf) is a multifunctional glycoprotein with well-established antimicrobial, anti-inflammatory, and iron-binding properties. Emerging evidence suggests that Lf also plays neuroprotective role, particularly in neurodegenerative disorders characterized by protein aggregation, such as Parkinson’s disease (PD). Alpha-synuclein (aSyn) aggregation pathological hallmark of PD other synucleinopathies, contributing to neuronal dysfunction progression. Recent studies indicate may interfere aSyn iron chelation, modulation oxidative stress neuroinflammation. Additionally, Lf’s ability cross the blood-brain barrier its potential impact on gut-brain axis highlight promise therapeutic agent. This review explores mechanisms action disease-modifying therapy, innovative delivery strategies could enhance clinical applicability. By addressing dimensions we propose compelling candidate for future research development diseases.

Language: Английский

Citations

0