The Complex Nature of Hippocampal-Striatal Interactions in Spatial Navigation

Frontiers in Human Neuroscience, Journal Year: 2018, Volume and Issue: 12

Published: June 21, 2018

Decades of research have established the importance hippocampus for episodic and spatial memory. In navigation tasks, role has been classically juxtaposed with dorsal striatum, latter which characterized as a system important implementing stimulus-response action-outcome associations. many neuroimaging paradigms, this explored through contrasting way finding route-following behavior. The distinction between contributions striatum to supported by extensive literature. Convergent also underscored fact that these different memory systems can interact in dynamic ways contribute broad range navigational scenarios. For example, although familiar routes may often be navigable based on associations, hippocampal mechanisms egocentric route-oriented memory, enabling recall context-dependent sequences landmarks or actions made at decision points. Additionally, literature stressed subdividing into functional gradients-with more ventral medial components being behavioral expression hippocampal-dependent memories. More is needed reveal how networks involving regions process respond changes control demands over course events. Perspective article, we suggest critical direction further characterize striatal subdivisions contexts.

Language: Английский

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Microglia morphology and proinflammatory signaling in the nucleus accumbens during nicotine withdrawal

Science Advances, Journal Year: 2019, Volume and Issue: 5(10)

Published: Oct. 9, 2019

Smoking is the largest preventable cause of death and disease in United States. However, <5% quit attempts are successful, underscoring urgent need for novel therapeutics. Microglia one untapped therapeutic target. While previous studies have shown that microglia mediate both inflammatory responses brain plasticity, little known regarding their role nicotine dependence withdrawal phenotypes. Here, we examined microglial changes striatum-a mesolimbic region implicated rewarding effects drugs affective disruptions occurring during withdrawal. We show induce morphological changes; however, proinflammatory anxiogenic behaviors were observed only Pharmacological depletion prevented these effects. These results define differential on signaling brain, laying groundwork development future smoking cessation

Language: Английский

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Oxycodone in the Opioid Epidemic: High ‘Liking’, ‘Wanting’, and Abuse Liability

Cellular and Molecular Neurobiology, Journal Year: 2020, Volume and Issue: 41(5), P. 899 - 926

Published: Nov. 27, 2020

Language: Английский

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Animal models for the study of depressive disorder

CNS Neuroscience & Therapeutics, Journal Year: 2021, Volume and Issue: 27(6), P. 633 - 642

Published: March 1, 2021

Abstract Depressive disorder is one of the most widespread forms psychiatric pathology, worldwide. According to a report by World Health Organization, number people with depression, globally, increasing dramatically each year. Previous studies have demonstrated that various factors, including genetics and environmental stress, contribute risk depression. As such, it crucial develop detailed understanding pathogenesis depressive animal are essential for identifying mechanisms genetic disorders underlying Recently, many researchers reported on pathology depression via models disorder. Given different show differences in terms patterns behavior comparison between necessary progress field study. However, not been fully compared or evaluated until now. In this paper, we reviewed pathophysiology its current analysis their transcriptomic profiles. We provide insights selecting study

Language: Английский

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Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain

Journal of Neuroinflammation, Journal Year: 2022, Volume and Issue: 19(1)

Published: July 14, 2022

Depression is a recurrent and devastating mental disease that highly prevalent worldwide. Prolonged exposure to stressful events or environment detrimental health. In recent years, an inflammatory hypothesis has been implicated in the pathogenesis of stress-induced depression. However, less attention given initial phases, when series stress reactions immune responses are initiated. Peripheral CD4+ T cells have reported as major contributors occurrence disorders. Chronic exposure-evoked release cytokines can promote differentiation peripheral into various phenotypes. Among them, Th17 attracted much due their high pathogenic potential central nervous system (CNS) diseases. Thus, we intended determine crucial role development specific subtypes depression unravel underpinnings pathogenetic effect.In present research, daily 6-h restraint paradigm was employed rats for 28 successive days mimic repeated mild predictable, but inevitable environmental our lives. Then, depressive-like symptoms, brain-blood barrier (BBB) permeability, neuroinflammation, functional changes were investigated.We noticed restrained showed significant concomitant BBB disruption neuroinflammation dorsal striatum (DS). We further observed time-dependent increase thymus- spleen-derived naïve cells, well aggregation DS during period chronic (CRS) exposure. Moreover, increased Th17-derived brain impair integrity, thus allowing more gain easy access CNS. Our findings suggested that, through complex cascade events, propagated CNS, gradually exacerbated symptoms. Furthermore, inhibiting function with SR1001 early stages CRS ameliorated CRS-induced behaviour response.Our data demonstrated pivotal accelerating onset exacerbation depressive symptoms CRS-exposed rats. This subtype may be promising therapeutic target treatment

Language: Английский

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