Altered Patterns of Maternal Behavior Transitions in Rats Exposed to Limited Bedding and Nesting Material Paradigm

Brain and Behavior, Journal Year: 2024, Volume and Issue: 14(10)

Published: Oct. 1, 2024

ABSTRACT Introduction Maternal care plays a fundamental role in early life, and the alteration of its patterns can negatively affect developmental course offspring myriad domains both rats humans. The limited bedding nesting (LBN) protocol is an extensively used paradigm rodents to address impact altered maternal behavior on infants' neurodevelopment. Here, we explore LBN conditions by describing sequences transition between components using network analysis. Using this technique, capture how often transitions take place during period which behaviors play central roles those over time. Materials Methods Female their pups were placed standard housing from Postpartum Days 2 9, was observed light dark phases. We inferential statistical analysis compare profiles control dams, sequence LBN. Results Compared dams significantly increased high crouch nursing posture light/dark phases ( p = 0.018), number behavioral only phase 0.0004). Network revealed specific characterized predominance switches active postures first five days protocol. Conclusion Nursing most disrupted component under protocol, mainly phase. complement extend traditional methods gain more thorough understanding strategies potential consequences for offspring.

Language: Английский

Alterations of Neurohumoral Response to Acute Stress in Spontaneously Hypertensive Rats Subjected to Long-Term Isolation

Journal of Evolutionary Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 60(S1), P. S169 - S182

Published: Dec. 1, 2024

Language: Английский