Resveratrol: Extraction Techniques, Bioactivity, and Therapeutic Potential in Ocular Diseases DOI Creative Commons
Giulia Accomasso,

Flavia Turku,

Simona Sapino

et al.

Scientia Pharmaceutica, Journal Year: 2024, Volume and Issue: 92(4), P. 59 - 59

Published: Nov. 14, 2024

Resveratrol (RV), a natural polyphenol found in various plants, exhibits wide range of bioactive properties and mechanisms action. Its potential therapeutic benefits several diseases and, more specifically, ocular have garnered significant attention, with studies exploring RV at cellular, molecular, physiological levels. Like many derivatives, can be obtained through extraction methods from plant sources, growing interest sustainable techniques that align recent trends sustainability, circular economy, green chemistry. This review begins by describing the most efficient sources then delves into its numerous synergistic effects other active substances drugs. Furthermore, an overview scientific literature on as agent for diseases, both pure form entrapped nanoparticulate systems, is provided.

Language: Английский

Association between the systemic immunity-inflammation index and stroke: a population-based study from NHANES (2015–2020) DOI Creative Commons

Rui Shi,

Ye Tian, Jinzhou Tian

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

Background The systemic immunity-inflammation index(SII) is a new indicator of composite inflammatory response. Inflammatory response an important pathological process in stroke. Therefore, this study sought to investigate the association between SII and Methods We collected data on participants with stroke from 2015–2020 cycle National Health Nutrition Examination Survey (NHANES) for cross-sectional investigation. Multivariate linear regression models were used test Fitted smoothing curves threshold effect analysis applied describe nonlinear relationship. Results A total 13,287 included our study, including 611 (4.598%) In multivariate analysis, we found significant positive stroke, odds ratio (OR) [95% CI] associating prevalence was [1.02 (1.01, 1.04)] (P < 0.01). subgroup interaction experiments, that relationship not significantly correlated among different population settings such as age, gender, race, education level, smoking status, high blood pressure, diabetes coronary heart disease trend > 0.05). Moreover, inflection point 740 (1,000 cells /µl) by using two-segment model. Conclusions This implies increased levels are linked To confirm findings, more large-scale prospective investigations needed.

Language: Английский

Citations

3
Electroacupuncture Improves Learning and Memory Impairment in Rats with Cerebral Ischemia/Reperfusion Injury by Promoting Microglia/Macrophage M2 Polarization Through Nrf2/HO-1 Pathway DOI Creative Commons

Yuqian Xiao,

Yan-Jie Bai,

Kexin Sun

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 2925 - 2941

Published: Feb. 1, 2025

While electroacupuncture (EA) has shown effectiveness in treating learning and memory deficits associated with ischemic stroke (IS), the specific mechanisms involved remain unclear. The goal of this study was to investigate whether EA improves MCAO rats by regulating microglia/macrophage polarization through nuclear factor red lineage 2-related 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway. Sprague-Dawley were subjected modeling treated 24 hours post-MCAO for a period two weeks. To involvement Nrf2/HO-1 effects EA, tin protoporphyrin (SnPPIX), an inhibitor HO-1, injected into left ventricle before initiating treatment. Neurological function evaluated using neurological deficit score. on assessed Morris water maze (MWM) open field test (OFT). Hematoxylin-Eosin (HE) staining used observe hippocampal structural morphology, 2,3,5-Triphenyltetrazolium Chloride (TTC) assess infarct volume. Protein expression levels pathway microglial/macrophage determined ELISA, immunofluorescence double-labeling, Western blotting (WB), real-time quantitative polymerase chain reaction PCR (qRT-PCR). significantly enhanced upregulating NRF2/HO-1 promoting M2 microglia/macrophages. However, administration SnPPIX, HO-1 inhibitor, counteracted beneficial improvement rats, while also worsening cerebral volume inflammatory response. effectively improved impairments activating pathway, leading promotion

Language: Английский

Citations

0
Dietary selenium mitigates cadmium-induced apoptosis and inflammation in chicken testicles by inhibiting oxidative stress through the activation of the Nrf2/HO-1 signaling pathway DOI Creative Commons
Yulong Li, Shu Wang, Rui Feng

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: 104(4), P. 104990 - 104990

Published: March 8, 2025

Cadmium (Cd) is a non-essential heavy metal that highly toxic to testicle. Selenium (Se) known possess antagonistic effects against Cd toxicity, yet the precise mechanisms through which Se counteracts Cd-induced testicular damage in chickens Nuclear factor erythroid 2-related 2/Heme oxygenase-1 (Nrf2/HO-1) signaling pathway, oxidative stress (OS), apoptosis, and inflammation remained unclear. In present study, experimental model of chicken testis was established by incorporating CdCl2 Na2SeO3 into dietary intake. After 60 days, from each group were euthanized, serum samples subsequently collected. Ultrastructural assessment revealed supplementation significantly mitigated induced Cd. effectively suppressed elevation ROS, MDA, H2O2 levels, while also preventing downregulation CAT, GSH, T-AOC levels. Furthermore, administration ameliorated reduction expression levels Nrf2, HO-1, Bcl-2 Cd, counteracted overexpression Caspase-3, Bax, Cyt-c, Caspase-9, TNF-α, IL-2, IL-6, IL-1β. Meanwhile, immunofluorescence data demonstrated attenuated decrease Nrf2 HO-1 upregulation IL-6 expression. conclusion, this study elucidated might mitigate testicles stimulation Nrf2/HO-1 thereby inhibiting apoptosis inflammation, beneficial reducing injury.

Language: Английский

Citations

0
Nuclear factor erythroid 2-related factor improves depression and cognitive dysfunction in rats with ischemic stroke by mediating wolfram syndrome 1 DOI

Guangxu Hu,

Hongjun Cao

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149572 - 149572

Published: March 1, 2025

Language: Английский

Citations

0
Hypothalamus-pituitary-adrenal axis in patients with post-traumatic stress disorders and related to oxidative stress DOI
Ali M.A. Al-Kufaishi,

Noor J. T. Al-Musawi

Hormone Molecular Biology and Clinical Investigation, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 13, 2024

The study involves the effect of hypothalamus-pituitary-adrenal hormones disorders, and related to oxidative stress in individuals with PTSD those healthy group after they experience a specific event that results congenital illness or limb loss.

Language: Английский

Citations

0
Resveratrol: Extraction Techniques, Bioactivity, and Therapeutic Potential in Ocular Diseases DOI Creative Commons
Giulia Accomasso,

Flavia Turku,

Simona Sapino

et al.

Scientia Pharmaceutica, Journal Year: 2024, Volume and Issue: 92(4), P. 59 - 59

Published: Nov. 14, 2024

Resveratrol (RV), a natural polyphenol found in various plants, exhibits wide range of bioactive properties and mechanisms action. Its potential therapeutic benefits several diseases and, more specifically, ocular have garnered significant attention, with studies exploring RV at cellular, molecular, physiological levels. Like many derivatives, can be obtained through extraction methods from plant sources, growing interest sustainable techniques that align recent trends sustainability, circular economy, green chemistry. This review begins by describing the most efficient sources then delves into its numerous synergistic effects other active substances drugs. Furthermore, an overview scientific literature on as agent for diseases, both pure form entrapped nanoparticulate systems, is provided.

Language: Английский

Citations

0