Evaluating post‐thrombectomy effective connectivity changes in anterior circulation stroke DOI Creative Commons
Jiaona Xu, Weiwei Chen,

Guozhong Niu

et al.

Annals of Clinical and Translational Neurology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Abstract Objective Granger causal analysis (GCA) and amplitude of low‐frequency fluctuation (ALFF) are commonly used to evaluate functional alterations in brain disorders. By combining the GCA ALFF, this study aimed investigate effective connectivity (EC) changes patients with acute ischemic stroke (AIS) anterior circulation occlusion after mechanical thrombectomy (MT). Methods Resting‐state magnetic resonance imaging (rs‐fMRI) data were collected from 43 AIS within 1 week post‐MT 37 healthy controls. ALFF calculated for each participant. Patients further divided into groups based on prognosis perfusion levels. The differences EC compared between controls subgroups patients. Pearson correlations EC, values, clinical characteristics calculated. Results Compared controls, post‐MT, exhibited significant increases left precuneus decreases fusiform gyrus right caudate. Increased contralesional lingual gyrus, putamen, ipsilesional thalamus, thalamus caudate was obsrved, while decrease found medial superior frontal gyrus. particularly notable groups, significantly lower poorly perfused group. values also positively correlated National Institutes Health Stroke Scale (NIHSS) scores pre‐MT. Interpretation In patients, nucleus central observed characterized by decreased outputs increased inputs. These indicate remodeling cortico‐basal ganglia‐thalamic‐cortical pathway.

Language: Английский

Temporal electroencephalography features unveiled via olfactory stimulus as biomarkers for mild Alzheimer’s disease DOI
Bilal Orkan Olcay, Murat Pehlivan, Bilge Karaçalı

et al.

Biomedical Signal Processing and Control, Journal Year: 2025, Volume and Issue: 104, P. 107566 - 107566

Published: Jan. 27, 2025

Language: Английский

Citations

0
The abnormal accumulation of pathological proteins and compensatory functional connectivity enhancement of insula subdivisions in mild cognitive impairment DOI Creative Commons

Darui Zheng,

Chen Xue, Yunlu Feng

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: March 18, 2025

The insula is a critical node of the salience network responsible for initiating switching, and its dysfunctional connections are linked to mechanisms mild cognitive impairment (MCI). This study aimed explore changes in functional connectivity (FC) insular subregions MCI patients with varying levels cerebrospinal fluid (CSF) pathological proteins, investigate impact these proteins on brain alterations MCI. Based CSF Amyloid-beta (Aβ, A) phosphorylated tau protein (p-tau, T), were classified into 54 A-T-, 28 A+T-, 52 A+T+ groups. Seed-based FC analysis was employed compare differences across three Correlation further conducted relationship between altered function. Finally, ROC curve used assess diagnostic value subregion distinguishing In left ventral anterior insula, dorsal bilateral posterior subnetworks, both A+T- groups showed increased compared A-T- group, group showing group. Additionally, cerebellar lobe negatively correlated RAVLT-learning, middle frontal gyrus p-tau levels. logistic regression demonstrated that multivariable had high sensitivity specificity abnormal exhibit compensatory increases subregions, which turn affect Our findings contributed better understanding pathophysiology underlying neural

Language: Английский

Citations

0
Smoking alters effective connectivity of resting-state brain networks in mild cognitive impairment DOI
Tianyi Zhang, Xiao Luo, Qingze Zeng

et al.

Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: May 4, 2025

Background Smoking, a modifiable risk factor for Alzheimer's disease (AD), is associated with impaired functional connectivity in resting-state networks (RSNs). This study investigates how smoking affects brain effective (EC). Objective Investigate smoking-associated EC alterations. Methods We identified 129 cognitively unimpaired (CU: 85 non-smokers, 44 smokers) and 84 mild cognitive impairment (MCI: 55 29 participants. Granger causality analysis was used to calculate the directed interactions of information flows based on seed areas default mode network, executive control salience network. Mixed-effect analyses were performed explore interactive effects × status. Linear mixed-effects models evaluated correlations between values longitudinal decline. Results revealed significant differences among 4 groups: (1) Smoking MCI individuals showed reduced from left putamen frontoinsular cortex (FIC) compared CU non-smoking group; (2) Non-smoking subjects had lower dorsolateral prefrontal (DLPFC) right inferior occipital gyrus (IOG) than CU; (3) exhibited increased DLPFC middle cingulate individuals. Additionally, Posterior cortex−to−IOG Putamen−to−FIC significantly predicted MMSE ADNI_EF scores over time, respectively. Conclusions distinctly impacts within RSNs overall function both individuals, potentially reducing compensation MCI. These results support cessation as part AD management strategies.

Language: Английский

Citations

0
Resting-state connectivity modifies the effects of amyloid on cognitive and physical function: evidence for network-based cognitive reserve DOI Creative Commons
Paul J. Laurienti, Stephen B. Kritchevsky, Robert G. Lyday

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Abstract Cognitive and physical function are interrelated in aging co-occurring impairments both domains can be debilitating lead to increased risk of developing dementia. Amyloid beta (Aβ) deposition the brain is linked cognitive decline also associated with poorer older adults. However, significant inter-individual variability exists respect influence Aβ concentrations on outcomes. Identifying factors that explain associations between clinical outcomes could inform interventions designed delay declines function. reserve (CR) considered a buffer allows for performance better than expected given level injury or pathology. Although neural mechanisms underlying CR remain unknown, there growing evidence resting-state networks may serve as surrogate CR. The currently study evaluated whether functional modified community-dwelling adults from Brain Networks Mobility (B-NET) study. We found integrity central executive basal ganglia performance. Associations were less pronounced when network was high. current introduces novel against accumulation Significance Statement There number medications targeting amyloid treatment Alzheimer’s disease. treatments effectively lower but do not have robust an effect normal cognition. Future studies should examine if underlies response amyloid-lowering drugs patients decline.

Language: Английский

Citations

0
Evaluating post‐thrombectomy effective connectivity changes in anterior circulation stroke DOI Creative Commons
Jiaona Xu, Weiwei Chen,

Guozhong Niu

et al.

Annals of Clinical and Translational Neurology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Abstract Objective Granger causal analysis (GCA) and amplitude of low‐frequency fluctuation (ALFF) are commonly used to evaluate functional alterations in brain disorders. By combining the GCA ALFF, this study aimed investigate effective connectivity (EC) changes patients with acute ischemic stroke (AIS) anterior circulation occlusion after mechanical thrombectomy (MT). Methods Resting‐state magnetic resonance imaging (rs‐fMRI) data were collected from 43 AIS within 1 week post‐MT 37 healthy controls. ALFF calculated for each participant. Patients further divided into groups based on prognosis perfusion levels. The differences EC compared between controls subgroups patients. Pearson correlations EC, values, clinical characteristics calculated. Results Compared controls, post‐MT, exhibited significant increases left precuneus decreases fusiform gyrus right caudate. Increased contralesional lingual gyrus, putamen, ipsilesional thalamus, thalamus caudate was obsrved, while decrease found medial superior frontal gyrus. particularly notable groups, significantly lower poorly perfused group. values also positively correlated National Institutes Health Stroke Scale (NIHSS) scores pre‐MT. Interpretation In patients, nucleus central observed characterized by decreased outputs increased inputs. These indicate remodeling cortico‐basal ganglia‐thalamic‐cortical pathway.

Language: Английский

Citations

0