Hypoxia and aging: molecular mechanisms, diseases, and therapeutic targets DOI Creative Commons
Ayesha Nisar,

Sawar Khan,

Wen Li

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(11)

Published: Oct. 15, 2024

Abstract Aging is a complex biological process characterized by the gradual decline of cellular functions, increased susceptibility to diseases, and impaired stress responses. Hypoxia, defined as reduced oxygen availability, critical factor that influences aging through molecular pathways involving hypoxia‐inducible factors (HIFs), oxidative stress, inflammation, epigenetic modifications. This review explores interconnected roles hypoxia in aging, highlighting how hypoxic conditions exacerbate damage, promote senescence, contribute age‐related pathologies, including cardiovascular neurodegenerative disorders, cancer, metabolic dysfunctions, pulmonary conditions. By examining mechanisms linking we identify key serve potential therapeutic targets. Emerging interventions such HIF modulators, antioxidants, senolytics, lifestyle modifications hold promise mitigating adverse effects on tissues. However, challenges heterogeneity lack reliable biomarkers, safety concerns regarding hypoxia‐targeted therapies remain. emphasizes need for personalized approaches advanced technologies develop effective antiaging interventions. integrating current knowledge, this provides comprehensive framework underscores importance targeting hypoxia‐induced enhance healthy reduce burden diseases.

Language: Английский

Dysfunctional mitochondria in age-related neurodegeneration: Utility of melatonin as an antioxidant treatment DOI Creative Commons
Russel J. Reıter, Ramaswamy Sharma, Walter Manucha

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 101, P. 102480 - 102480

Published: Sept. 3, 2024

Mitochondria functionally degrade as neurons age. Degenerative changes cause inefficient oxidative phosphorylation (OXPHOS) and elevated electron leakage from the transport chain (ETC) promoting increased intramitochondrial generation of damaging reactive oxygen nitrogen species (ROS RNS). The associated progressive accumulation molecular damage causes an increasingly rapid decline in mitochondrial physiology contributing to aging. Melatonin, a multifunctional free radical scavenger indirect antioxidant, is synthesized matrix neurons. Melatonin reduces ETC elevates ATP production; it also detoxifies ROS/RNS via SIRT3/FOXO pathway upregulates activities superoxide dismutase 2 glutathione peroxidase. influences glucose processing by In neurogenerative diseases, often adopt Warburg-type metabolism which excludes pyruvate mitochondria causing reduced acetyl coenzyme A production. Acetyl supports citric acid cycle OXPHOS. Additionally, required co-substrate for arylalkylamine-N-acetyl transferase, rate limits melatonin synthesis; therefore, production diminished cells that experience making more vulnerable stress. Moreover, endogenously produced diminishes during aging, further increasing components. More normal preserved aging with supplementation.

Language: Английский

Citations

12
Using Zebrafish Models to Study Epitranscriptomic Regulation of CNS Functions DOI
Jianzhong Jiang, Yun‐Qian Zhang,

Jiyi Wang

et al.

Journal of Neurochemistry, Journal Year: 2025, Volume and Issue: 169(1)

Published: Jan. 1, 2025

Epitranscriptomic regulation of cell functions involves multiple post-transcriptional chemical modifications coding and non-coding RNA that are increasingly recognized in studying human brain disorders. Although rodent models presently widely used neuroepitranscriptomic research, the zebrafish (Danio rerio) has emerged as a useful promising alternative model species. Mounting evidence supports importance CNS function, providing additional insights into epitranscriptomic mechanisms underlying wide range Here, we discuss recent data on role regulation, with particular focus models, well evaluate current problems, challenges, future directions research this field molecular neurochemistry.

Language: Английский

Citations

0
The role of Ergothioneine in cognition and age-related neurodegenerative disease: a systematic review DOI

Nurfarah Hazwani Takhor,

Chia‐Wei Phan

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Language: Английский

Citations

0
Hypoxia and aging: molecular mechanisms, diseases, and therapeutic targets DOI Creative Commons
Ayesha Nisar,

Sawar Khan,

Wen Li

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(11)

Published: Oct. 15, 2024

Abstract Aging is a complex biological process characterized by the gradual decline of cellular functions, increased susceptibility to diseases, and impaired stress responses. Hypoxia, defined as reduced oxygen availability, critical factor that influences aging through molecular pathways involving hypoxia‐inducible factors (HIFs), oxidative stress, inflammation, epigenetic modifications. This review explores interconnected roles hypoxia in aging, highlighting how hypoxic conditions exacerbate damage, promote senescence, contribute age‐related pathologies, including cardiovascular neurodegenerative disorders, cancer, metabolic dysfunctions, pulmonary conditions. By examining mechanisms linking we identify key serve potential therapeutic targets. Emerging interventions such HIF modulators, antioxidants, senolytics, lifestyle modifications hold promise mitigating adverse effects on tissues. However, challenges heterogeneity lack reliable biomarkers, safety concerns regarding hypoxia‐targeted therapies remain. emphasizes need for personalized approaches advanced technologies develop effective antiaging interventions. integrating current knowledge, this provides comprehensive framework underscores importance targeting hypoxia‐induced enhance healthy reduce burden diseases.

Language: Английский

Citations

3