Brain-targeted autoimmunity is strongly associated with Long COVID and its chronic fatigue syndrome as well as its affective symptoms DOI Creative Commons
Abbas F. Almulla, Michaël Maes, Bo Zhou

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Autoimmune responses contribute to the pathophysiology of Long COVID, affective symptoms and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). To examine whether its accompanying CFS are associated with immunoglobulin (Ig)A/IgM/IgG directed at neuronal proteins including myelin basic protein (MBP), oligodendrocyte glycoprotein (MOG), synapsin, α + β-tubulin, neurofilament (NFP), cerebellar protein-2 (CP2), blood-brain-barrier-brain-damage (BBD) claudin-5 S100B. IgA/IgM/IgG above proteins, human herpes virus-6 (HHV-6) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) were measured in 90 COVID patients healthy controls, while C-reactive (CRP), advanced oxidation products (AOPP) association ratings additionally assessed a subgroup thereof. is significant increases IgG tubulin (IgG-tubulin), MBP, MOG synapsin; IgM-MBP, MOG, CP2, synapsin BBD; IgA-CP2 synapsin. IgM-SARS-CoV-2 IgM-HHV-6 antibody titers significantly correlated IgA/IgG/IgM-tubulin -CP2, IgG/IgM-BBD, IgM-MOG, IgA/IgM-NFP, IgG/IgM-synapsin. Binary logistic regression analysis shows that IgM-MBP IgG-MBP best predictors COVID. Multiple IgG-MOG, CRP AOPP explain together 41.7 % variance severity CFS. Neural network IgM-synapsin, IgA-MBP, IgA-synapsin, IgA-CP2, most important due predictive accuracy r = 0.801. Brain-targeted autoimmunity contributes pathogenesis physio-affective phenome.

Language: Английский

Exercise-induced adaptations in the kynurenine pathway: implications for health and disease management DOI Creative Commons
Marcus Vinícius dos Santos Rangel, Karynne Grutter Lopes, Xuebin Qin

et al.

Frontiers in Sports and Active Living, Journal Year: 2025, Volume and Issue: 7

Published: March 6, 2025

Background Tryptophan (TRP) metabolism through the kynurenine (KYN) pathway is influenced by inflammatory mediators, generating metabolites that regulate immune and responses. Exercise has been proposed as a modulator of this pathway, but its role in health benefits chronic disease management remains unclear. Objective This systematic review examines exercise-induced adaptations KYN their potential implications for management. Additionally, we identify key methodological considerations future research. Methods A structured search PubMed/Medline, Web Science, Scopus was conducted up to October 2024 clinical trials investigating effects exercise training on pathway. Results Of 2,795 articles initially found, 13 involving 592 participants met inclusion criteria. Most studies reported particularly cancer survivors. These appeared be intensity duration. However, several limitations were noted, no included patients with metabolic or cardiovascular diseases. Conclusions Here, show modulates both healthy diseased populations, highlighting prevention further randomized-controlled are needed clarify mechanisms applications, Systematic Review Registration https://www.crd.york.ac.uk/PROSPERO/view/CRD42022351481 , PROSPERO (CRD42022351481).

Language: Английский

Citations

0
Brain-targeted autoimmunity is strongly associated with Long COVID and its chronic fatigue syndrome as well as its affective symptoms DOI Creative Commons
Abbas F. Almulla, Michaël Maes, Bo Zhou

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Autoimmune responses contribute to the pathophysiology of Long COVID, affective symptoms and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). To examine whether its accompanying CFS are associated with immunoglobulin (Ig)A/IgM/IgG directed at neuronal proteins including myelin basic protein (MBP), oligodendrocyte glycoprotein (MOG), synapsin, α + β-tubulin, neurofilament (NFP), cerebellar protein-2 (CP2), blood-brain-barrier-brain-damage (BBD) claudin-5 S100B. IgA/IgM/IgG above proteins, human herpes virus-6 (HHV-6) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) were measured in 90 COVID patients healthy controls, while C-reactive (CRP), advanced oxidation products (AOPP) association ratings additionally assessed a subgroup thereof. is significant increases IgG tubulin (IgG-tubulin), MBP, MOG synapsin; IgM-MBP, MOG, CP2, synapsin BBD; IgA-CP2 synapsin. IgM-SARS-CoV-2 IgM-HHV-6 antibody titers significantly correlated IgA/IgG/IgM-tubulin -CP2, IgG/IgM-BBD, IgM-MOG, IgA/IgM-NFP, IgG/IgM-synapsin. Binary logistic regression analysis shows that IgM-MBP IgG-MBP best predictors COVID. Multiple IgG-MOG, CRP AOPP explain together 41.7 % variance severity CFS. Neural network IgM-synapsin, IgA-MBP, IgA-synapsin, IgA-CP2, most important due predictive accuracy r = 0.801. Brain-targeted autoimmunity contributes pathogenesis physio-affective phenome.

Language: Английский

Citations

1