The neuroprotective role of Humanin in Alzheimer's disease: The molecular effects

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177510 - 177510

Published: March 1, 2025

Humanin (HN) is an endogenous micropeptide also known as a mitochondria-derived peptide. It has neuroprotective effect against Alzheimer's disease (AD) and other neurodegenerative diseases by improving hippocampal acetylcholine attenuating the development of oxidative stress associated neurotoxicity. HN protects neuron from toxic effects amyloid beta (Aβ). regarded biomarker mitochondrial stress. Interestingly, aging reduces brain expression HN, leading to cognitive impairment elevating risk neurodegeneration, including AD. However, in old subjects AD patients, circulating levels increase compensatory mechanism reduce neurodegeneration dysfunction Conversely, studies demonstrated reduction These findings indicated controversial points regarding precise mechanistic role Therefore, aim this review was discuss exact neuropathology molecular mechanisms

Language: Английский

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Whole exome sequencing in 33 patients revealed 4 novel variants in 11 limbs-girdle muscular dystrophy families

Gene Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102218 - 102218

Published: April 1, 2025

Language: Английский

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Peripheral lymphocyte counts and regional cerebral blood flow on brain SPECT correlate in Alzheimer’s disease: A retrospective cross-sectional study

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149657 - 149657

Published: April 1, 2025

Language: Английский

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Ginsenoside Rg1 alleviates cognitive impairment in vascular dementia by modulating Adcy1/Kdr–mediated cholinergic synapse and PI3K–AKT pathway

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156882 - 156882

Published: May 1, 2025

Language: Английский

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