Human Stem Cell-Derived GABAergic Interneuron Development Reveals Early Emergence of Subtype Diversity Followed by Gradual Electrochemical Maturation DOI

Marina Bershteyn,

Hongjun Zhou,

Luis C. Fuentealba

et al.

Published: Jan. 1, 2024

Language: Английский

Advances in neural stem cells in aging and age-related neurodegenerative diseases DOI Open Access
Rujia Zhong, Wenhao Huang, Chao Chen

et al.

Ageing and Neurodegenerative Diseases, Journal Year: 2025, Volume and Issue: 5(1)

Published: Jan. 26, 2025

With aging, neural stem cells (NSCs) undergo age-related changes, including metabolic abnormalities, disrupted protein homeostasis, mitochondrial dysfunction, reduced genetic stability, and more notably, a diminished capacity for proliferation differentiation. These changes may contribute to the development of neurodegenerative diseases such as Alzheimer’s disease (AD) Parkinson’s (PD). In these conditions, disease-specific pathological interact with alterations NSCs, resulting in impairment neurogenesis, which further leads cognitive, mood, motor decline. Based on potential therapeutics targeting neurogenesis cell-based therapies restore functions NSCs replace degenerated neurons, aiming ameliorate functional decline diseases. While therapies, cell transplantation secretome therapy, show great treatment diseases, challenges tumorigenesis, immune rejection, extraction or storage need be addressed. A better understanding age- disease-related underlying mechanism driving benefits drawbacks therapeutic approaches provide insights novel disease-modifying interventions future

Language: Английский

Citations

0
Age-Related Neurodegenerative Diseases: A Stem Cell’s Perspective DOI Creative Commons
Belén Calvo, Pierre Schembri-Wismayer, María Beatriz Durán Alonso

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(5), P. 347 - 347

Published: Feb. 27, 2025

Neurodegenerative diseases encompass a number of very heterogeneous disorders, primarily characterized by neuronal loss and concomitant decline in neurological function. Examples this type clinical condition are Alzheimer's Disease, Parkinson's Huntington's Disease Amyotrophic Lateral Sclerosis. Age has been identified as major risk the etiology these which explains their increased incidence developed countries. Unfortunately, despite continued intensive efforts, no cure yet found for any diseases; reliable markers that allow an early diagnosis disease identification key molecular events leading to onset progression lacking. Altered adult neurogenesis appears precede appearance severe symptoms. Given scarcity human samples considerable differences with model species, increasingly complex stem-cell-based models being developed. These shedding light on alterations contribute development, facilitating new targets providing screening platform testing candidate drugs. Moreover, secretome other promising features cell types explored, use them replacement cells high plasticity or co-adjuvant therapy combinatorial treatments.

Language: Английский

Citations

0
Regenerative Medicine in Plastic Surgery: The Role of Stem Cells and Bioprinting DOI Creative Commons
Kirolos Eskandar

Regenesis repair rehabilitation., Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Innovative approaches to treatment of eye diseases: advances in stem cell therapy use in ophthalmology DOI

Victor Oluwatomiwa Ajekiigbe,

Chinonyelum Emmanuel Agbo,

Ikponmwosa Jude Ogieuhi

et al.

International Ophthalmology, Journal Year: 2025, Volume and Issue: 45(1)

Published: March 22, 2025

Language: Английский

Citations

0
A Comprehensive Review on Stimuli-Responsive Nanomaterials: Advancements in Wound Healing and Tissue Regeneration DOI

M. Bellarmin,

J. Nandhini,

Karthikeyan Elumalai

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Language: Английский

Citations

0
Gene therapy for neurologic disorders DOI Creative Commons
Florian Eichler,

Robert H. Brown

Neurotherapeutics, Journal Year: 2024, Volume and Issue: 21(4), P. e00453 - e00453

Published: July 1, 2024

Language: Английский

Citations

3
Fundamentals of Stem Cells and Application in Complex Disorders DOI Creative Commons
Gaurav Verma,

Srividhya Ravichandran

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Stem cells possess an outstanding ability to differentiate into various cell types, making them instrumental in human physiology and regenerative medicine. This chapter explores the fundamentals of stem their applications complex disorders like neurodegeneration cardiovascular disorders. are undifferentiated capable self-renewal differentiation specialised including neurons, muscle blood cells. They further categorised embryonic adult Understanding biology is crucial for harnessing potential treating diabetes, neurodegenerative diseases, autoimmune conditions. cell-based therapy offers promising avenues reversing damaged tissues organs, as well providing models studying disease mechanisms drug discovery. Recent advancements induced pluripotent (iPSCs) have enabled generation patient-specific cells, allowing personalised therapies medicine modelling. However, extreme challenges remain, availability donors, characterisation efficacy, ethical concerns, tumourigenicity immune rejection. In summary, hold immense promise next-generation by offering novel therapeutic strategies albeit investigation essential address existing realise unprecedented

Language: Английский

Citations

0
Gut Microbes: Therapeutic Target for Neuropsychiatric Disorders DOI
Keya Mallick, Gopal Khodve,

Ritika Ruwatia

et al.

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 184, P. 27 - 38

Published: Feb. 21, 2025

Language: Английский

Citations

0
Introducing the Gene & Cell Therapy Study Group of the ASNR, ASFNR, and ASPNR DOI
Kazim Narsinh, P. Ellen Grant, Ramon Barajas

et al.

American Journal of Neuroradiology, Journal Year: 2025, Volume and Issue: 46(4), P. 646 - 647

Published: April 1, 2025

Language: Английский

Citations

0
Human Stem Cell-Derived GABAergic Interneuron Development Reveals Early Emergence of Subtype Diversity Followed by Gradual Electrochemical Maturation DOI

Marina Bershteyn,

Hongjun Zhou,

Luis C. Fuentealba

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0